Detailed methods are provided in the online version of this paper and include the following: immunohistological analyses. The samples were evaluated by an experienced liver pathologist. All human samples were obtained with written informed consent from the patients or their relatives, and after authorization by the Hospital Committee for Investigation in Humans. No donor organs were obtained from executed prisoners or other institutionalized individuals. All human studies were conducted in accordance with the principles of the Declaration of Helsinki.
Cell lines AML12 mouse liver cells and HEK293T cells were obtained from the American Type Culture Collection (Manassas, VA, USA) and cultured in Dulbecco's modified Eagle medium/nutrient mixture F12 (Thermo Fisher Scientific, Waltham, MA, USA) containing 100 units/mL of penicillin, 100 mg/mL of streptomycin, 100 mL/mL of ITS liquid media supplement, 40 ng/mL of dexamethasone, and 10% of fetal bovine serum at 37 C in an incubator with 5% CO 2 . All in vitro experiments were repeated three times, and each treatment was repeated.
Cell lines AML12 mouse liver cells and HEK293T cells were obtained from the American Type Culture Collection (Manassas, VA, USA) and cultured in Dulbecco's modified Eagle medium/nutrient mixture F12 (Thermo Fisher Scientific, Waltham, MA, USA) containing 100 units/mL of penicillin, 100 mg/mL of streptomycin, 100 mL/mL of ITS liquid media supplement, 40 ng/mL of dexamethasone, and 10% of fetal bovine serum at 37 C in an incubator with 5% CO 2 . All in vitro experiments were repeated three times, and each treatment was repeated.