Pdgf cc

Manufactured by Thermo Fisher Scientific

Sourced in United States

PDGF-CC is a recombinant human platelet-derived growth factor subunit C protein. It is a member of the platelet-derived growth factor family, which plays a role in cell growth and division.

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Lab products found in correlation

3 protocols using pdgf cc

Procurement and Preparation of Growth Factors

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All GFs and chemokines were purchased in their mature forms, highly pure (>95% pure), carrier-free, and lyophilized^{35 (link)}. VEGF-A121, VEGF-A165, PlGF-1, PlGF-2, PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD, FGF-1, FGF-2, FGF-6, FGF-7, FGF-9, FGF-10, FGF-18, BMP-2, BMP-3, BMP-4, BMP-7, β-NGF, NT-3, BDNF, IGF-1, IGF-2, HB-EGF, CXCL-11, and CXCL-12α were purchased from PeproTech. CXCL-12γ was purchased from R&D systems. Except for PDGF-DD and BMP-7, which were produced in eukaryotic cells, all GFs were produced in Escherichia coli and thus were not glycosylated. All GFs were reconstituted and stored according to the provider’s instructions to regain full activity and prevent loss of protein.

Ishihara J., Ishihara A., Fukunaga K., Sasaki K., White M.J., Briquez P.S, & Hubbell J.A. (2018). Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing. Nature Communications, 9, 2163.

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PDGF Induces Blood-Brain Barrier Opening

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Example 1

Wild type C57BL6 mice (10 Week old) were injected intraventricularly into the dorsal third ventricle with 2 μl of PBS, active PDGF-AA, PDGF-BB (both from Preprotech Inc.) and PDGF-CC (see below) (3 μM). Evans Blue was given intravenously immediately after the injection. One hour after the injection, the animals were perfused with PBS and the brain tissue was removed and processed for Evans Blue extravasation.

As shown in FIG. 1, all three PDGFs, in the CSF, are potent inducers of opening of the BBB.

US10676527B2. Methods and compositions for modulation of blood-neural barrier (2020-06-09). Ludwig Institute for Cancer Research Ltd [CH], The Regents of the University of Michigan [US], University of Maryland, Baltimore [US]. Inventors: Ulf Eriksson [SE], Linda Fredriksson [SE], Daniel Lawrence [US], Enming Su [US], Manuel Yepes [US], Dudley Strickland [US].

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Growth Factor Cocktail Protocol

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The growth factor cocktail consists of recombinant human platelet-derived growth factor-CC (PDGF-CC; PeproTech, Rocky Hill, NJ, USA), recombinant heparin-binding epidermal growth factor-like growth factor (HB-EGF; PeproTech), and human recombinant Midkine (MDK; PeproTech).

Woo J., Suh W, & Sung J.H. (2022). Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12). International Journal of Molecular Sciences, 23(16), 9467.

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