Embase

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Embase is a comprehensive biomedical literature database that provides access to journal articles, conference abstracts, and other scientific publications. It covers a wide range of medical and scientific disciplines, including pharmacology, toxicology, and drug-related information.

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Lab products found in correlation

Scopus, by Elsevier (63 mentions) Cinahl, by EBSCO (36 mentions) Medline, by Elsevier (35 mentions) Web of science, by Clarivate (23 mentions) Psycinfo, by EBSCO (18 mentions) Pubmed, by Elsevier (18 mentions) Web of science core collection, by Clarivate (15 mentions) Cinahl, by Elsevier (13 mentions) Psycinfo, by Elsevier (12 mentions) Cinahl complete, by EBSCO (10 mentions) Web of science, by Elsevier (9 mentions) Medline, by EBSCO (8 mentions) Endnote 20, by Clarivate (5 mentions) Web of science, by Thomson Reuters (4 mentions) Endnote x9, by Clarivate (4 mentions) Sciencedirect, by Elsevier (3 mentions) Cochrane library, by Elsevier (3 mentions) Global health, by Elsevier (3 mentions) Cinahl plus, by EBSCO (3 mentions) Web of science core collection, by Elsevier (3 mentions)

250 protocols using embase

Quantitative Meta-Analysis of ET for SVC Syndrome

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For this quantitative meta-analysis of full-length journal articles on the use of ET for the treatment of SVC syndrome, we performed a systematic literature review. To identify studies to include or consider for this systematic review, the review team worked with a medical librarian (SCR) to develop detailed search strategies for each database. The search was developed for PubMed (NLM) and was translated to Embase (Elsevier) and Cochrane Central (Wiley) using a combination of keywords and subject headings. A gray literature search included ClinicalTrials.gov and the TRIP database. The search included no major limits and was limited to 1988 to present studies. The final search was completed on September 25, 2020. The search was updated on April 14, 2021.
PubMed (NLM) from 1988 to 9/25/2020 (3593 Results)
PubMed (NLM) from 9/25/2020 to 4/14/2021 (136 Results)
Embase (Elsevier) from 1988 to 9/25/2020 (3333 Results)
Embase (Elsevier) from 9/25/2020 to 4/14/2021 (187 Results)
Cochrane Central (Wiley) from 1988 to 9/25/2020 (81 Results)
Cochrane Central (Wiley) from 9/25/2020 to 4/14/2021 (7 Results)

Azizi A.H., Shafi I., Zhao M., Chatterjee S., Roth S.C., Singh M., Lakhter V, & Bashir R. (2021). Endovascular therapy for superior vena cava syndrome: A systematic review and meta-analysis. EClinicalMedicine, 37, 100970.

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AI-Assisted Adenoma Detection in Colonoscopy

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A comprehensive search of the following databases was conducted from inception until April 24, 2023, using multiple databases including MEDLINE (PubMed platform, NCBI), Embase (Embase.com, Elsevier), Web of Science Core Collection, Korean Citation Index, and SciELO (Clarivate), Global Index Medicus (World Health Organization), and Cochrane Central Register of Controlled Trials (Cochrane Library, Wiley). Screening of key reference / bibliographic lists for more studies was additionally performed. The keywords/ subject terms used to search were ‘colonoscopy,’ ‘adenoma,’ ‘artificial intelligence,’ ‘adenoma detection rate,’ ‘single blind’ ‘double blind,’ and ‘dual observer’ along with their corresponding medical subject heading terms, in various combinations. There were no language restrictions or filters applied. The search strategy was created by an experienced librarian (WLS) and reviewed by another investigator (MKG). The detailed search strategy can be reviewed in Supplementary Table 1.

Gangwani M.K., Haghbin H., Ishtiaq R., Hasan F., Dillard J., Jabbar F., Dahiya D.S., Ali H., Salim S., Lee-Smith W., Sohail A., Inamdar S., Aziz M, & Hart B. (2024). Single Versus Second Observer vs Artificial Intelligence to Increase the ADENOMA Detection Rate of Colonoscopy—A Network Analysis. Digestive Diseases and Sciences, 69(4), 1380-1388.

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Comprehensive Literature Search Protocol

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We will search the following electronic databases since the inception date up to February 27, 2019: MEDLINE (PubMed), CENTRAL, and EMBASE (Elsevier, EMBASE.com">EMBASE.com) using the appropriate thesaurus and free-text terms. We will contact investigators and relevant trial authors, seeking information on unpublished data, if necessary.
We will check the reference lists of all the studies identified, and we will examine the references of any systematic review or meta-analysis identified during the search process.
No restriction on language or publication period will be applied. Non-English studies for which a translation cannot be obtained will be classed as potentially eligible but will not be considered in the full review. A full electronic search strategy for PubMed/MEDLINE is presented in Additional file 2.

Gianola S., Castellini G., Andreano A., Corbetta D., Frigerio P., Pecoraro V., Redaelli V., Tettamanti A., Turolla A., Moja L, & Valsecchi M.G. (2019). Effectiveness of treatments for acute and sub-acute mechanical non-specific low back pain: protocol for a systematic review and network meta-analysis. Systematic Reviews, 8, 196.

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Systematic Review of TIPS Outcomes in Elderly Patients

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A comprehensive search strategy to identify reports of three specific outcomes (HE, 30- and 90-day mortality, and readmission due to HE) in elderly patients after undergoing TIPS was developed in Embase (Embase.com, Elsevier) by an experienced health sciences librarian (WLS) using truncated keywords, phrases, and subject headings. This strategy was translated to MEDLINE (PubMed platform, NCBI), Cochrane Central Register of Controlled Trials (CochraneLibrary.com, Wiley), and the Web of Science Core Collection (Web of Science platform, Clarivate) with all searches performed from January 1960 till 25 January 2022 (Supplementary Material 1, www.gastrores.org). No publication date or language limits were used. Results were uploaded to the citation management software EndNote 20 (Clarivate, Philadelphia, PA, USA), and duplicates were removed by EndNote algorithms and manual inspection. No human or animal subjects were utilized in this study and meta-analysis. Institutional Review Board approval was not required.

Ahmed Z., Farooq U., Faiza Arif S., Aziz M., Iqbal U., Nawaz A., Lee-Smith W., Badal J., Mahmood A., Kobeissy A., Nawras A., Hassan M, & Saab S. (2022). Transjugular Intrahepatic Portosystemic Shunt Outcomes in the Elderly Population: A Systematic Review and Meta-Analysis. Gastroenterology Research, 15(6), 325-333.

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Systematic Review of HRQOL Instruments

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Articles for review were identified from MEDLINE (via PubMed) and Embase (via Elsevier), which were searched from 1946 (MEDLINE) and 1966 (Embase) to December 31, 2014 with the assistance of an experienced reference librarian (L.H.). Key words and controlled vocabulary were used for each database, and searches were constructed using a combination of medical subheadings, keywords, and text words. As physical symptom assessments are often embedded in HRQOL assessments, we conducted searches for HRQOL or symptoms. Complete search strings are available in Table S1 (provided as online supplementary material). Reference lists of selected studies were further searched for additional instruments and articles. Individual instruments were identified within each of the articles. Focused searches to identify psychometric analyses of the identified instruments were then performed.

Flythe J.E., Powell J.D., Poulton C.J., Westreich K.D., Handler L., Reeve B.B, & Carey T.S. (2015). Patient-Reported Outcome Instruments for Physical Symptoms Among Patients Receiving Maintenance Dialysis: A Systematic Review. American journal of kidney diseases : the official journal of the National Kidney Foundation, 66(6), 1033-1046.

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Systematic Scoping Review of Type 1 Diabetes Incidence

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In designing and conducting this scoping review, we adopted the methodological framework proposed by Arksey and O’Malley [13 (link)]. A systematic scoping review was conducted according to the PRISMA recommendations retrieved from original papers published in English up to April 12, 2021, in peer-reviewed journals reporting the incidence of T1D among individuals aged <25 years of age in population-based studies and reporting the diagnostic criteria used to define T1D. The databases used for the literature search were Medline / PubMed (National Library of Medicine, NCBI), Embase (Elsevier, Embase.com), and Global Health (C.A.B. International, Ebsco). The protocol for the search was registered in the International Prospective Register of Systematic Reviews (PROSPERO). Controlled vocabulary terms (i.e. MeSH, Emtree, CAB Thesaurus) were included when available and appropriate. The search strategies were designed and executed by a librarian (CM) from Harvard University in discussion with the authors. Tables A and B in S1 Text outline both the concepts and controlled vocabulary used for the search strategy and summary. Fig 1 presents the flow diagram of the bibliographic search using the PRISMA 2020 checklist (PRISMA-ScR checklist shown in S1 Text). Ethics approval for performing the study was not required as no primary data were included.

Gomber A., Ward Z.J., Ross C., Owais M., Mita C., Yeh J.M., Reddy C.L, & Atun R. (2022). Variation in the incidence of type 1 diabetes mellitus in children and adolescents by world region and country income group: A scoping review. PLOS Global Public Health, 2(11), e0001099.

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Epigenetic Modifications of BDNF in Brain Disorders

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PubMed (NLM), Embase (Elsevier), APA PsycInfo (Ovid), and Cochrane Protocols (Wiley) were searched; health sciences librarians with systematic review experience (AMK, HMV) assisted with the development of all searches. The completion date of the initial searches was 20 April 2020. A citation analysis of included studies from the original search indicated that only studies from PubMed (NLM) and Embase (Elsevier) were included, which were last updated 17 September 2021 and 27 September 2021 respectively. Concepts that made up the search were: (1) BDNF; (2) epigenomic modification (e.g. DNAm, non-coding RNA, or histone modification); and (3) brain-related conditions or correlates (e.g. central nervous system diseases, psychiatric disorders, trauma, cognition, etc.). A combination of MeSH terms and title, abstract, and keywords were used to develop the initial PubMed search which was checked against a known set of studies. The search was then adapted to search the other databases. EndNote (Clarivate) was used to sort and store citations; duplicates were removed using the processes described by Bramer et al. and Otten et al. (Bramer et al., 2016 (link); Otten et al., 2019 ). We limited the search to studies on humans and published in English. The complete search strategy can be found in Appendix A.

Treble-Barna A., Heinsberg L.W., Stec Z., Breazeale S., Davis T.S., Kesbhat A.A., Chattopadhyay A., VonVille H.M., Ketchum A.M., Yeates K.O., Kochanek P.M., Weeks D.E, & Conley Y.P. (2023). Brain-derived neurotrophic factor (BDNF) epigenomic modifications and brain-related phenotypes in humans: A systematic review. Neuroscience and biobehavioral reviews, 147, 105078.

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Palliative Care for Sexual and Gender Minorities

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Six databases were selected: PubMed (via National Library of Medicine’s PubMed.gov), Embase (via Elsevier’s Embase.com">Embase.com), Cochrane Central Register of Controlled Trials/Cochrane CENTRAL (via Wiley’s Cochrane Library), PsycINFO (via Ovid), Cumulative Index to Nursing and Allied Health Literature (via EBSCO), and Scopus (via Elsevier). The search strategy was developed in PubMed by a research informationist (KG) in collaboration with the research team using Medical Subject Headings (MeSH) and keywords for two concepts: Sexual and Gender Minorities and Palliative Care. Concepts were combined with the Boolean AND operator, and restrictions were added for English language and publication dates in or after 2010, the year when the data from the last systematic review was captured. The Cochrane Handbook filter was used to exclude animal-only studies.²⁸ A second research informationist performed a Peer Review of Electronic Search Strategies (PRESS), and edits were implemented.²⁹ The search strategy was then translated to the other databases using available filters and controlled vocabulary. For a complete strategy, see the accompanying PubMed search displayed in Supplemental Material. The databases were searched on November 6, 2020. Results were entered in Covidence, a web-based software platform for systematic review development that includes the deduplication of uploaded records.³⁰

Rosa W.E., Roberts K.E., Braybrook D., Harding R., Godwin K., Mahoney C., Mathew S., Atkinson T.M., Banerjee S.C., Haviland K., Hughes T.L., Walters C.B, & Parker P.A. (2022). Palliative and end-of-life care needs, experiences, and preferences of LGBTQ+ individuals with serious illness: A systematic mixed-methods review. Palliative medicine, 37(4), 460-474.

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COVID-19 Vaccine-Induced Lymphadenopathy

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We searched various online data sources, including Scopus, Medline (PubMed), Web of Science, The Cochrane Library, Embase (Elsevier), and Google Scholar from January 1, 2019, to February 28, 2021, and updated on March 25, 2021. All types of studies, including original research studies, clinical perspective, case series/reports, editorials, and commentaries were assessed. Studies on COVID-19 vaccinated individuals (with any type of COVID-19 vaccine with the United States FDA approval) presented with LAP by various imaging modalities such as sonography, mammography, MRI, PET/CT scan, and PET/MRI were included. Duplicates, studies reported other adverse events of COVID-19 vaccines rather than adenopathy, and studies without available full text were excluded. Keywords of literature search included “COVID-19,” “coronavirus disease,” “SARS-CoV-19,” “Vaccin*,” and “Vaccination,” “Immunization,” “side effect*,” “adenopath*,” and “Lymphadenopathy.” The details of the PubMed keywords search strategy are presented in appendix A.

Keshavarz P., Yazdanpanah F., Rafiee F, & Mizandari M. (2021). Lymphadenopathy Following COVID-19 Vaccination: Imaging Findings Review. Academic Radiology, 28(8), 1058-1071.

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Efficacy of Cleaning and Disinfection Against SARS-CoV-2

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The search strategy was elaborated in accordance with the following research question: Is there any evidence that it is important to use cleaning and disinfection products against SARS-CoV-2?
The searches were elaborated using health science descriptors and adapted for use in each of the databases selected: Cochrane Library (Wiley); Embase (Elsevier); VHL Portal; Medical Literature Analysis and Retrieval System Online (MEDLINE, PubMed); CINAHL; Web of Science; Scopus; and Opengrey (https://opengrey.eu). These descriptors were as follows: “severe acute respiratory syndrome coronavirus 2”[Supplementary Concept] OR “severe acute respiratory syndrome coronavirus 2”[All Fields] OR “sars cov 2”[All Fields]) AND (“environment”[MeSH Terms] OR “environment”[All Fields]) AND (“disinfection”[MeSH Terms] OR “disinfection”[All Fields]).
A manual search was conducted in the references of the primary and secondary studies that were identified through the electronic search. The search strategies developed and used for each electronic database were performed between April 29, 2020 and May 27, 2020. They are presented in Table 1. There were no restrictions on languages or forms of publication.

Shimabukuro P.M., Duarte M.L., Imoto A.M., Atallah Á.N., Franco E.S., Peccin M.S, & Taminato M. (2020). Environmental cleaning to prevent COVID-19 infection. A rapid systematic review. São Paulo Medical Journal, 138(6), 505-514.

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