Serotonin hydrochloride

Manufactured by Bio-Techne

Sourced in United Kingdom

Serotonin hydrochloride is a chemical compound used in various research and laboratory applications. It serves as a neurotransmitter and is commonly used in the study of biological processes and neurological functions.

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Lab products found in correlation

Sr95531, by Bio-Techne (2 mentions) Kynurenic acid, by Merck Group (2 mentions) Arg8 vasopressin acetate salt, by Merck Group (2 mentions) Rpmi 1640, by Thermo Fisher Scientific (2 mentions) Paroxetine hydrochloride hemihydrate, by Merck Group (1 mentions) Fetal bovine serum (fbs), by Thermo Fisher Scientific (1 mentions) Versene, by Thermo Fisher Scientific (1 mentions) Fluoxetine hydrochloride, by Merck Group (1 mentions) Ly215840, by Bio-Techne (1 mentions) Pen strep, by Thermo Fisher Scientific (1 mentions) Forskolin, by Bio-Techne (1 mentions) Isoproterenol hydrochloride, by Bio-Techne (1 mentions) Hepes solution, by Thermo Fisher Scientific (1 mentions) Dantrolene sodium salt, by Bio-Techne (1 mentions) Nkh 477, by Bio-Techne (1 mentions) Phorbol 12 myristate 13 acetate pma, by Bio-Techne (1 mentions) Isoproterenol hydrochloride, by R&D Systems (1 mentions) 3 isobutyl 1 methylxanthine ibmx, by MP Biomedicals (1 mentions) Ym 254890, by Focus Biomolecules (1 mentions) M csf, by Thermo Fisher Scientific (1 mentions)

Close spelling variants of this product

Serotonin (7 citations)

7 protocols using serotonin hydrochloride

Neurotransmitter Receptor Binding Assay

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Paroxetine hydrochloride hemihydrate (MW 374.83) and Fluoxetine hydrochloride (MW
345.79) were purchased from Sigma-Aldrich (St Louis, MO). Serotonin hydrochloride (M,
217.18) and LY 215840 (MW 400.04) were obtained from Tocris bioscience (Bristol, UK). RPMI
1640 (Rosewell Park Memorial Institute) media, Fetal Bovine Serum (FBS), Pen-strep
(Penicillin Streptomycin mixtures contain 5,000 units of penicillin and 5,000 μg of
streptomycin/ml in saline) and Versene (0.2 g EDTA/liter of PBS) were purchased from Life
technologies (Carlsbad, CA). Ultrapure LPS (from 0111:B4 E. Coli) was
obtained from Invivogen (San Diego, CA).

Durairaj H., Steury M.D, & Parameswaran N. (2015). Paroxetine differentially modulates LPS-induced TNFα and IL-6 production in mouse macrophages. International immunopharmacology, 25(2), 485-492.

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Macrophage Activation Signaling Compounds

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RPMI-1640 and penicillin-streptomyocin (P/S) from Invitrogen (Carlsbad, CA). Human AB serum and fetal bovine serum (FBS) from Mediatech (Tewksbury, MA). HEPES solution from Fisher Scientific (Fair Lawn, NJ). Dantrolene sodium salt, serotonin hydrochloride, isoproterenol hydrochloride, NKH 477, forskolin and phorbol 12-myristate 13-acetate (PMA) from Tocris Biosciences (Minneapolis, MN). isoproterenol hydrochloride from R&D Systems (Minneapolis MN). Dopamine and H89 dihydrochloride from Sigma-Aldrich (St. Louis, MO). 3-Isobutyl-1-methylxanthine (IBMX) from MP Biomedicals (Santa Ana, CA). RO-20-1724 from EMD Millipore (Temecula, CA). YM-254,890 from Focus Biomolecules (Plymouth Meeting, PA). Dopamine and the beta-adrenergic receptor agonist Isoproterenol were resuspended in distilled H₂O to make stock concentrations of 10 mM, then diluted into media as needed. RO-20-1724 (200 mM), IBMX (100 mM), forskolin (10 mM), YM-254,890 (10 mM) and PMA (100 μM) were resuspended in DMSO to the indicated concentrations, then diluted into media as indicated. Human macrophage colony stimulating factor (M-CSF) was from Peprotech (Rocky Hill, NJ) and resuspended in 100 μL distilled H₂O.

Nickoloff E.A., Mackie P., Runner K., Matt S.M., Khoshbouei H, & Gaskill P.J. (2019). Dopamine increases HIV entry into macrophages by increasing calcium release via an alternative signaling pathway. Brain, behavior, and immunity, 82, 239-252.

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Serotonin Receptor Pharmacology Assay

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Serotonin hydrochloride, MDL 72,222, RS 102221, MDL 100,907, SR95531 and CGP 54626 hydrochloride were purchased from Tocris Bioscience UK. Picrotoxin, kynurenic acid and α-Methylserotonin maleate salt were purchased from Sigma-Aldrich UK.

Bocchio M., Fucsina G., Oikonomidis L., McHugh S.B., Bannerman D.M., Sharp T, & Capogna M. (2015). Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala. Neuropsychopharmacology, 40(13), 3015-3026.

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Neurotransmitter Receptor Agonist Protocol

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Dopamine hydrochloride was purchased from Alfa Aesar (Ward Hill, MA). Serotonin hydrochloride, α-methyl-5HT, quinpirole hydrochloride, SCH23390, WAY100635, yohimbine, naftopidil hydrochloride, nomifensine and apamin were purchased from Tocris Biosciences (Minneapolis, MN). Sulpiride and ML297 were purchased from Abcam (Cambridge, MA). Norepinephrine, barium and all reagents used to prepare aCSF, sucrose-containing and internal pipette solution were purchased from Sigma (St. Louis, MO).

Nimitvilai S., Lopez M.F, & Woodward J.J. (2018). Effects of monoamines on the intrinsic excitability of lateral orbitofrontal cortex neurons in alcohol-dependent and non-dependent female mice. Neuropharmacology, 137, 1-12.

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Neuroactive Compounds Acquisition Protocol

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Serotonin hydrochloride, Histamine dihydrochloride, Asenapine maleate were purchased from Tocris, Dopamine hydrochloride, Epinephrine hydrochloride, [Arg8]-Vasopressin acetate salt, Paliperidone, Somatostatin were obtained from Sigma-Aldrich, Aripiprazole was purchased from Toronto Research Chemical.

Galinski S., Wichert S.P., Rossner M.J, & Wehr M.C. (2018). Multiplexed profiling of GPCR activities by combining split TEV assays and EXT-based barcoded readouts. Scientific Reports, 8, 8137.

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Neurotransmitter Receptor Modulators

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Serotonin hydrochloride, WAY 100635 maleate, NBQX, D-APV, and SR95531 were purchased from Tocris Bioscience. Kynurenic acid and tamoxifen were purchased from Sigma-Aldrich.

Bocchio M., Fisher S.P., Unal G., Ellender T.J., Vyazovskiy V.V, & Capogna M. (2016). Sleep and Serotonin Modulate Paracapsular Nitric Oxide Synthase Expressing Neurons of the Amygdala. eNeuro, 3(5), ENEURO.0177-16.2016.

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Pharmacological Compounds for Research

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The dopamine hydrochloride, [Arg8]-vasopressin acetate salt, and glucagon were purchased from Sigma-Aldrich (St. Louis, MO, USA). The serotonin hydrochloride was obtained from Tocris. The liraglutide (NN2211) was purchased from Selleck Chemicals (Houston, TX, USA).

Wu Y., von Hauff I.V., Jensen N., Rossner M.J, & Wehr M.C. (2022). Improved Split TEV GPCR β-arrestin-2 Recruitment Assays via Systematic Analysis of Signal Peptide and β-arrestin Binding Motif Variants. Biosensors, 13(1), 48.

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