Methohexital

Manufactured by Merck Group

Methohexital is a barbiturate-based anesthetic agent used in the laboratory setting. It is a white crystalline powder that is soluble in water and organic solvents. Methohexital is utilized for its anesthetic properties in various experimental procedures and research applications.

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Lab products found in correlation

Nicotine bitartrate, by Merck Group (1 mentions) Nicotine hydrogen tartrate salt, by MP Biomedicals (1 mentions)

Close spelling variants of this product

Methohexital sodium (2 citations)

2 protocols using methohexital

Nicotine Bitartrate Administration Protocol

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Nicotine bitartrate (Sigma Chemical Co., St. Louis, MO) was dissolved into sterile saline. The pH of the solution was adjusted to 7.4 with dilute NaOH, and heparin (30 units/ml) was added to help maintain catheter patency. Nicotine doses are expressed as the base. Methohexital (Sigma Chemical Co., St. Louis, MO) was dissolved in sterile saline (0.1ml, 10 mg/ml, i.v.) and used to assess catheter patency.

Bunney P.E., Burroughs D., Hernandez C, & LeSage M.G. (2015). The effects of nicotine self-administration and withdrawal on concurrently available chow and sucrose intake in adult male rats. Physiology & behavior, 154, 49-59.

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Nicotine Self-Administration Procedure

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Nicotine hydrogen tartrate salt (MP Biomedicals, Solon, OH) was dissolved in 0.9% saline. Doses are expressed as free-base. Methohexital (Sigma, St. Louis, MO) was used at the dose 5 mg/kg to test catheter patency. All self-administered solutions were passed through a 0.22-μm filter to ensure sterility.

Rupprecht L.E., Kreisler A.D., Spierling S.R., de Guglielmo G., Kallupi M., George O., Donny E.C., Zorrilla E.P, & Sved A.F. (2018). Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats. Psychopharmacology, 235(4), 1131-1140.

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