Log In Sign up
The largest database of trusted experimental protocols

Hespan

Manufactured by B. Braun
Visit Supplier
Sourced in United States, United Kingdom

Hespan is a colloid solution used for intravenous administration. It contains hydroxyethyl starch, which helps maintain blood volume and osmotic pressure. Hespan is intended for use as a plasma volume expander.

Automatically generated - may contain errors

Lab products found in correlation

3 isobutyl 1 methylxanthine ibmx, by Merck Group (1 mentions) Forskolin, by Merck Group (1 mentions) Isoproterenol hcl, by Merck Group (1 mentions) Mrs1754, by Bio-Techne (1 mentions) Hetastarch, by B. Braun (1 mentions)

Spelling variants of this product

HESPAN Hetastarch (2 citations)

4 protocols using hespan

1

Mobilization and Harvest of Stem Cells

Check if the same lab product or an alternative is used in the 5 most similar protocols
The donors were primed with G-CSF injected subcutaneously at a dose of 5 μg/kg/day for 5 consecutive days. On the sixth day, BM cells and PBSCs were harvested. The target mono-nuclear cell count was above 3×108 cells/kg of the recipient’s weight. PBSCs were collected using a blood cell separator (COBE Spectra LRS, Ceridian BCT, Inc., Lakewood, CO, USA) from a total blood volume of 150–200 mL/kg. In case of ABO major blood group compatibility, fresh and unmanipulated BM and PBSCs were immediately infused into the recipient after collection. However, in case of ABO major blood group incompatibility, the red cells were removed from the stem cells by density gradient sedimentation with Hespan according to the manufacturer’s instructions (B. Braun Medical Inc., Irvine, CA, USA). The surface markers of the graft cells were determined with monoclonal antibodies specific for CD34 using flow cytometry.
Mu Y., Qin M., Wang B., Li S., Zhu G., Zhou X., Yang J., Wang K., Lin W, & Zheng H. (2016). Haploidentical hematopoietic stem cell transplantation without total body irradiation for pediatric acute leukemia: a single-center experience. OncoTargets and therapy, 9, 2557-2563.
+ Open protocol
+ Expand
2

Allogeneic MSC Transplantation for Patients

Check if the same lab product or an alternative is used in the 5 most similar protocols
All donors received human granulocyte colony‐stimulating factor (G‐CSF) at a dose of 5 to 10 μg/kg/day for 4 to 5 consecutive days. Bone marrow cells were collected on day 4. The volume of the harvests was 10 to 20 mL/kg of donor. In the cases of ABO‐incompatibility, red blood cells were removed by sedimentation with Hespan (B. Braun Medical Inc., Irvine, California). Peripheral blood stem cells (PBSCs) were harvested on day 5. The total target mononuclear cells were ≥5 × 108/kg and CD34+ cells ≥2 × 106/kg of the recipient weight. The UC‐MSC (n = 75) or BM‐MSC (n = 28) were intravenously given to patients with a uniform cell number (1 × 106/kg of the recipient weight) with donor bone marrows.
Ding L., Han D., Zheng X., Yan H., Xue M., Liu J., Zhu L., Li S., Mao N., Guo Z., Ning H., Wang H, & Zhu H. (2020). A study of human leukocyte antigen‐haploidentical hematopoietic stem cells transplantation combined with allogenic mesenchymal stem cell infusion for treatment of severe aplastic anemia in pediatric and adolescent patients. Stem Cells Translational Medicine, 10(2), 291-302.
+ Open protocol
+ Expand
3

Synthesis and Characterization of ITI-214

Cited 1 time
Check if the same lab product or an alternative is used in the 5 most similar protocols
ITI-214 (full molecular weight (phosphate salt) = 606, 6aR,9aS)-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(phenyl-amino)-5,6a,7,8,9,9a-hexahydrocyclopenta-[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4-(2H)-one phosphate), was synthesized by Intra-Cellular Therapies, Inc. (New York, NY). Its Ki for full-length recombinant r-hPDE1A, 1B, and 1C is 34, 380, and 37 pM, respectively, with 900-fold greater activity toward PDE1C isoforms compared with the next nearest PDE family enzyme, PDE4D (Ki = 33 nM), and 104-3×105 -fold selectivity toward all other PDE enzyme families28 (link). Additional pharmaceuticals were dobutamine (Hospira Inc, Lake Forest, IL), esmolol HCl (Mylan, Rockford, IL), cilostamide, MRS1754 (Tocris Bioscience, Bristol, UK), Hespan (6% Hetastarch in 0.9% NaCl, B. Braun Medical Inc., Bethlehem, PA), forskolin, isoproterenol HCl, and 3-Isobutyl-1-methylxanthine (IBMX) (Sigma-Aldrich, St. Louis, MO).
Hashimoto T., Kim G.E., Tunin R.S., Adesiyun T., Hsu S., Nakagawa R., Zhu G., O’Brien J.J., Hendrick J.P., Davis R.E., Yao W., Beard D., Hoxie H.R., Wennogle L.P., Lee D.I, & Kass D.A. (2018). Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition: A translational study in the dog and rabbit. Circulation, 138(18), 1974-1987.
+ Open protocol
+ Expand
4

Granulocyte Stimulation and Collection

Check if the same lab product or an alternative is used in the 5 most similar protocols
For the stimulated granulocyte donations before July 2005, donors received 5 μg/kg G-CSF as a single subcutaneous injection 12 to 24 hours before donation and/or 8 mg dexamethasone orally 12 hours before donation. After July 2005, the G-CSF dose was changed to a standard 480 μg subcutaneous injection for all donors. The dexamethasone dose remained unchanged. G-CSF/Dex has been used for granulocyte donor stimulation at our institution since 1994. Stimulated donor granulocytes were collected for use as therapeutic transfusion components, at the request of and consultation with the primary treating physician, for patients with severe neutropenia or disorders of neutrophil function and life-threatening infections unresponsive to antimicrobial agents.
Granulocyte collection procedures were performed using continuous flow centrifugation on an apheresis device (Spectra, Terumo BCT; or CS-3000, Fenwal). Seven to 7.5 liters of whole blood was processed per procedure, at a blood flow rate of 50 to 70 mL/min. A quantity of 500 mL of hydroxyethyl starch solution (Hespan, B. Braun Medical) was used as a red cell sedimenting solution and injected with 30 mL of citrate (Tricitrasol, Cytosol Laboratories) for anticoagulation of the extracorporeal circuit.
Szymanski J., Troendle J., Leitman S., Hong H., Yau Y.Y, & Cantilena C. (2018). The effect of repeated stimulated granulocyte donations on hematopoietic indexes in donors: a 24-year donor center experience. Transfusion, 59(1), 259-266.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!