3d oct 2000 spectral domain

Manufactured by Topcon

Sourced in Japan

The 3D OCT-2000 Spectral Domain is a high-performance optical coherence tomography (OCT) system designed for comprehensive eye examinations. It uses spectral domain technology to capture detailed, three-dimensional images of the eye's structures, including the retina, optic nerve, and anterior segment.

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Lab products found in correlation

Retiport erg system, by Roland Consult (3 mentions) Spectralis hra oct, by Roland Consult (2 mentions) Hra 1, by Heidelberg Engineering (1 mentions) Qiaamp dna blood midi kit, by Qiagen (1 mentions)

4 protocols using 3d oct 2000 spectral domain

Comprehensive Ophthalmic Evaluation of CRD

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The proband was diagnosed with CRD and recruited at the Department of Ophthalmology, Peking Union Medical College Hospital (PUMCH). Ophthalmic examinations were performed including best-corrected visual acuity (BCVA) testing, fundus examination, optical coherence tomography (OCT, 3D OCT-2000 Spectral Domain; Topcon, Tokyo, Japan), autofluorescence (AF, Spectralis HRA+OCT; Heidelberg, Germany) and electroretinogram (ERG, RetiPort ERG system; Roland Consult, Wiesbaden, Germany). Informed consent was obtained from the patient for this study. Blood samples were obtained from the patient and her parents. This study adhered to the Declaration of Helsinki and was approved by the Institutional Review Board PUMCH.

Dharmat R., Liu W., Ge Z., Sun Z., Yang L., Li Y., Wang K., Thomas K., Sui R, & Chen R. (2017). IFT81 as a Candidate Gene for Nonsyndromic Retinal Degeneration. Investigative Ophthalmology & Visual Science, 58(5), 2483-2490.

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Comprehensive Ophthalmic Examination of Uyghur IRD Patients

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Uyghur IRD patients and other family members were ascertained at Minguang Ophthalmic Hospital (MOH), Hotan, Xinjiang, China. All patients provided written consent in accordance with the tenets of the Declaration of Helsinki. Comprehensive ophthalmic examinations including visual acuity testing (tumbling E chart), visual field testing (APS-6000, Xinchangzheng, Nanchang, China), optical coherence topography (OCT, 3D OCT-2000 Spectral Domain; Topcon, Tokyo, Japan) and funduscopy (APS-CER, Kanghua, Chongqing, China) were performed on each patient. Pedigrees were established by interviews. Genomic DNA was extracted from peripheral blood by using Qiagen kit (Qiagen Inc). All experimental methods were approved by the Institutional Review Boards of MOH and Chinese Academy of Sciences and were performed in accordance with relative guidelines and regulations.

Tajiguli A., Xu M., Fu Q., Yiming R., Wang K., Li Y., Eblimit A., Sui R., Chen R, & Aisa H.A. (2016). Next-generation sequencing-based molecular diagnosis of 12 inherited retinal disease probands of Uyghur ethnicity. Scientific Reports, 6, 21384.

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Clinical Evaluation and Genetic Analysis of STGD

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Probands and other family members were ascertained primarily at Peking Union Medical College Hospital (PUMCH, Beijing, China). Medical and family histories were recorded. Detailed ophthalmologic examinations, including visual acuities, color vision test (pseudoisochromatic plates and D-15 color plates), slit lamp biomicroscopy, tonometry and dilated ophthalmoscopy were conducted. Macular structure was examined with optical coherence tomography (OCT) (3D OCT-2000 Spectral Domain; Topcon, Tokyo, Japan). Auto fluorescence images (HRA 1; Heidelberg Engineering, Heidelberg, Germany) were obtained. Full-field ERGs were performed (RetiPort ERG system, Roland Consult, Wiesbaden, Germany) in selected patients. The method was performed in concordance with the International Society for Clinical Electrophysiology of Vision standard protocol (ISCEV).
Diagnosis of STGD was based on the clinical manifestations. Written informed consents were obtained from participants or their guardians. Genomic DNA was isolated from peripheral leukocytes using a commercial kit (QIAamp Blood Midi; Qiagen, Hilden, Germany) according to manufacturer's protocol. This study was approved by the Institutional Review Board of PUMCH and adhered to the tenets of the Declaration of Helsinki and the Guidance on Sample Collection of Human Genetic Diseases by the Ministry of Public Health of China.

Zaneveld J., Siddiqui S., Li H., Wang X., Wang H., Wang K., Li H., Ren H., Lopez I., Dorfman A., Khan A., Wang F., Salvo J., Gelowani V., Li Y., Sui R., Koenekoop R, & Chen R. (2014). Comprehensive analysis of Stargardt macular dystrophy patients reveals new genotype-phenotype correlations and unexpected diagnostic revisions. Genetics in medicine : official journal of the American College of Medical Genetics, 17(4), 262-270.

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Molecular Diagnosis of Leber Congenital Amaurosis and Retinitis Pigmentosa

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This study was approved by the Institutional Review Board of Peking Union Medical College Hospital (PUMCH) and adhered to the Declaration of Helsinki. Informed consent was obtained from all individual participants included in the study. All the probands were diagnosed at the Department of Ophthalmology, PUMCH (Beijing, China) by ophthalmic examinations including best corrected visual acuity (BCVA) testing, fundus examination, optical coherence topography (OCT, 3D OCT-2000 Spectral Domain; Topcon, Tokyo, Japan), visual field tests (Octopus, Interzeag, Schlieren, Switzerland), autofluorescence (AF, Spectralis HRA+OCT; Heidelberg, Germany) and electroretinogram (ERG, RetiPort ERG system, Roland Consult, Wiesbaden, Germany). LCA and RP were diagnosed according to medical and family history, typical fundus and OCT features, visual field defects and attenuated or abolished ERG responses. Blood samples were obtained from all patients and their family members if available. DNA was extracted using QIAamp DNA Blood Midi Kit as instructed by the manufacturer (QIAGEN, Hilden, Germany).

Xu M., Yang L., Wang F., Li H., Wang X., Wang W., Ge Z., Wang K., Zhao L., Li H., Li Y., Sui R, & Chen R. (2015). Mutations in human IFT140 cause non-syndromic retinal degeneration. Human genetics, 134(10), 1069-1078.

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