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Durvalumab

Manufactured by Selleck Chemicals
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Sourced in United States

Durvalumab is a laboratory reagent used in scientific research. It is a monoclonal antibody that binds to the protein PD-L1, which is involved in regulating the immune system. Durvalumab is used in various in vitro studies to investigate the role of the PD-1/PD-L1 pathway in cellular processes and immune responses.

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Lab products found in correlation

Triton x 100, by Thermo Fisher Scientific (1 mentions) Collagenase type 1, by Thermo Fisher Scientific (1 mentions) Glutaraldehyde, by Merck Group (1 mentions) 4 6 diamidino 2 phenylindole (dapi), by Merck Group (1 mentions) Px 478, by Selleck Chemicals (1 mentions) Ficoll paque density gradient medium, by Merck Group (1 mentions) Apatinib, by Selleck Chemicals (1 mentions)

3 protocols using durvalumab

1

Hypoxia Detection and Cell Culture

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Calcium chloride (CaCl2), trans-4-(Aminomethyl) cyclohexanecarboxylicacid (AMCHA), dimethyl sulfoxide (DMSO), Ficoll-Paque density gradient medium, DAPI, and glutaraldehyde, were purchased from Sigma-Aldrich (Saint Louis, MO). Type I collagenase and Image-iTTM Green Hypoxia detection reagent and Triton X-100 were purchased from Thermo Fischer Scientific (Waltham, MA). Cell tracker DiO (excitation, 488 nm; emission, 525/50 nm) was purchased from Invitrogen (Carlsbad, CA). Drugs including PX-478 and Durvalumab were purchased from Selleck Chemicals (Houston, TX).
Bhattacharya S., Calar K., Evans C., Petrasko M, & de la Puente P. (2020). Bioengineering the Oxygen-Deprived Tumor Microenvironment Within a Three-Dimensional Platform for Studying Tumor-Immune Interactions. Frontiers in Bioengineering and Biotechnology, 8, 1040.
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2

Inhibiting PD-L1 and VEGFR2 in Ovarian Cancer

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PD‐L1 inhibitor (durvalumab) and VEGFR2 inhibitor (apatinib) were obtained from Selleck Chemicals (Houston, TX, USA). OVCA433 and HeyA8 cells were treated with 4 μmol/L durvalumab (A2013), 20 μmol/L apatinib (S5248), and the two‐drug combination for 48 h using transwell and wound healing assays.
Yang Y., Xia L., Wu Y., Zhou H., Chen X., Li H., Xu M., Qi Z., Wang Z., Sun H, & Cheng X. (2021). Programmed death ligand‐1 regulates angiogenesis and metastasis by participating in the c‐JUN/VEGFR2 signaling axis in ovarian cancer. Cancer Communications, 41(6), 511-527.
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3

Immunomodulatory Agents in Preclinical Study

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Pembrolizumab (Catalog #A2005, batch A200504) and durvalumab (Catalog #2013) were purchased from Selleckchem (Houston, TX). InVivoMAb rat anti-mouse PD-1 (Clone RMP1-14, Catalog #BE0146) and InVivoPlus rat IgG2a isotype control (Clone 2A3, Catalog #BP0089) were purchased from BioXCell (West Lebanon, NH). Native human IgA protein (hIgA, Catalog #ab91025) was purchased from Abcam (Cambridge, MA). Human IgG1 (hIgG1) kappa isotype control (Catalog #C0001) and its hIgG1 H310Q mutant were supplied by Crown Biosciences (San Diego, CA). Cisplatin (00143950501) was purchased from Covetrus (Portland, ME).
Madan T., Kishore U., Singh M., Strong P., Hussain E.M., Reid K.B, & Sarma P.U. (2001). Protective Role of Lung Surfactant Protein D in a Murine Model of Invasive Pulmonary Aspergillosis. Infection and Immunity, 69(4), 2728-2731.
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