Tianeptine and haloperidol (Sigma Aldrich, St. Louis, MO, USA; Merck KGaA, Darmstadt, Germany) were dissolved in 0.9% NaCl. Separate groups of adolescent rats were treated with Tianeptine (10 mg/kg) or haloperidol (1.5 mg/kg)34 (link),35) (link) once daily for 21 consecutive days (postnatal day 35 to 56).10) (link) The duration of experimental manipulation used for rats (P35–P49) was selected because it roughly approximated mid-adolescence in human.36) (link) Each drug treatment was performed at 10 a.m. every day.
Tianeptine
Manufactured by Merck Group
Sourced in United States
Tianeptine is a laboratory equipment product manufactured by Merck Group. It is a versatile and reliable instrument designed for use in various research and analytical applications. The core function of Tianeptine is to provide accurate and consistent measurements, ensuring precise data collection for scientific investigations.
Automatically generated - may contain errors
Lab products found in correlation
Haloperidol, by Merck Group (3 mentions)
Imipramine, by Merck Group (3 mentions)
Risperidone, by Merck Group (2 mentions)
Buspirone, by Merck Group (2 mentions)
Clozapine, by Bio-Techne (2 mentions)
Aripiprazole, by Merck Group (2 mentions)
Bupropion, by Merck Group (2 mentions)
Alprazolam, by Merck Group (2 mentions)
Olanzapine, by Merck Group (2 mentions)
Diazepam, by Merck Group (2 mentions)
S duloxetine, by Merck Group (2 mentions)
Excitalopram, by Merck Group (2 mentions)
Fenobam, by Merck Group (2 mentions)
Escherichia coli 0111 b4, by Merck Group (1 mentions)
Dulbecco modified eagle medium (dmem), by Thermo Fisher Scientific (1 mentions)
Fetal bovine serum (fbs), by Thermo Fisher Scientific (1 mentions)
7 protocols using tianeptine
1
Adolescent Rat Pharmacology Intervention
2
Tianeptine Modulates LPS-Induced Responses
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In all presented experiments, cells were pretreated for 30 min with various concentrations of tianeptine (0.1, 1.0, 10.0, or 50 μM; Sigma-Aldrich, St. Louis, MO, USA), and were then stimulated with lipopolysaccharide (LPS; 100 ng/mL; Escherichia coli 0111:B4, Sigma-Aldrich, St. Louis, MO, USA). Control (unstimulated) cells were treated with vehicle (phosphate-buffered saline (PBS) buffer).
3
Antidepressant Drugs in Stress Response
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After the behavioral verification, the control and prenatally stressed offspring were divided into six experimental groups (CONTROL + VEH, CONTROL + IMI, CONTROL + TIA, STRESS + VEH, STRESS + IMI, STRESS + TIA; six animals per group) and were treated for 21 days with antidepressant drugs or vehicle. Imipramine (used as a reference drug to compare tianeptine efficiency in behavioral tests; Sigma-Aldrich, St. Louis, MO, USA), tianeptine (Servier, France) or vehicle (0.9 % saline, Polpharma, Poland) was injected intraperitoneally, once per day between 9:00 am and 10:00 am. Imipramine and tianeptine were injected at a dose of 10 mg/ml/kg in a volume of 1 ml/kg. Twenty-four hours after the last injection, the animals were sacrificed by rapid decapitation. The hippocampi and the frontal cortices were dissected.
4
Pharmacological Reference Compounds Acquisition
5
Pharmacological Reference Compounds Acquisition
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Psychiatric drug reference compounds were purchased from the following sources at the indicated purity. Haloperidol (Sigma-Aldrich, NA), Aripiprazole (Sigma-Aldrich, >98%), Clozapine (Tocris, >99%), Olanzapine (Sigma-Aldrich, >98%), Risperidone (Sigma-Aldrich, >98%), Bupropion (Sigma-Aldrich, >98%), (S)-Duloxetine (Sigma-Aldrich, >98%), Excitalopram (Sigma-Aldrich, >98%), Imipramine (Sigma-Aldrich, >98%), Tianeptine (Sigma-Aldrich, >98%), Buspirone (Sigma-Aldrich, NA), Fenobam (Sigma-Aldrich, >98%), Alprazolam (Sigma-Aldrich, NA), Diazepam (Sigma-Aldrich, NA).
6
Tianeptine Administration in Stress Model
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Tianeptine (Sigma-Aldrich, Seoul, Korea) was dissolved in 0.9% NaCl and injected intraperitoneally (10 mg/kg/daily once) for 24 days. Each drug treatment was performed every day at 10 a.m. during stress procedure.
7
Culturing SH-SY5Y Cells with Tianeptine
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SH-SY5Y, a human neuroblastoma cell line, was cultured in Dulbecco's modified Eagle's medium (DMEM) (Gibco BRL) containing 10% FBS (Gibco BRL). DMEM culture solution was changed every 48 hours until cell maturation. For experimental treatment, tianeptine (Sigma-Aldrich) was prepared at 10 or 20 µM before addition to cell cultures.
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