Log In Sign up
The largest database of trusted experimental protocols

Afatinib

Manufactured by ChemScene
Visit Supplier
Sourced in United States

Afatinib is a tyrosine kinase inhibitor used in research applications. It targets the epidermal growth factor receptor (EGFR) to inhibit cell proliferation. Afatinib can be used in in vitro and in vivo studies.

Automatically generated - may contain errors

Lab products found in correlation

Erlotinib, by ChemScene (1 mentions) Osimertinib, by ChemScene (1 mentions) 2 4 6 trinitrobenzene sulfonic acid, by Tokyo Chemical Industry (1 mentions) Vandetanib, by Adooq (1 mentions) Keyhole limpet hemocyanin klh, by Fujifilm (1 mentions) Horseradish peroxidase hrp, by Boehringer Ingelheim (1 mentions) 3 3 5 5 tetramethylbenzidine (tmb), by Boehringer Ingelheim (1 mentions)

2 protocols using afatinib

1

Synthesis and Evaluation of TAS6417

Check if the same lab product or an alternative is used in the 5 most similar protocols
TAS6417 was synthesized at Taiho Pharmaceutical Co., Ltd. (Tsukuba, Japan) (7 (link)). Osimertinib, poziotinib, afatinib, and erlotinib were purchased from CHEMSCENE, LLC, MedChem Express, Selleck Chemicals, and LC Laboratories, respectively.
Udagawa H., Hasako S., Ohashi A., Fujioka R., Hakozaki Y., Shibuya M., Abe N., Komori T., Haruma T., Terasaka M., Fujita R., Hashimoto A., Funabashi K., Yasuda H., Miyadera K., Goto K., Costa D.B, & Kobayashi S.S. (2019). TAS6417/CLN-081 is a pan-mutation-selective EGFR tyrosine kinase inhibitor with a broad spectrum of preclinical activity against clinically-relevant EGFR mutations. Molecular cancer research : MCR, 17(11), 2233-2243.
+ Open protocol
+ Expand
2

Quinazoline-based Inhibitor Synthesis

Check if the same lab product or an alternative is used in the 5 most similar protocols
Afatinib was obtained from ChemScene LLC (Monmouth Junction, NJ, USA). (S)-N-4-(3-Chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)-quinazoline-4,6-diamine (CTQD) was obtained from Toronto Research Chemicals, Inc. (Toronto, ON, Canada). N-4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine (CMQD) was obtained from Ark Pharm, Inc. (Libertyville, IL, USA). Vandetanib was obtained from AdooQ BioScience LLC (Irvine, CA, USA). 2,4,6-Trinitrobenzene sulfonic acid was obtained from Tokyo Chemical Industry Co., Ltd. (Tokyo, Japan). Keyhole limpet hemocyanin (KLH) was purchased from Wako Pure Chemical Industries, Ltd. (Osaka, Japan). Horseradish peroxidase (HRP) and 3,3′,5,5′-tetramethylbenzidine (TMB) were obtained from Boehringer Ingelheim Pharma GmbH (Ingelheim, Germany). The other reagents and solvents were all of the highest commercially available grade.
Sogawa R., Saita T., Yamamoto Y., Kimura S., Narisawa Y., Kimura S, & Shin M. (2018). Development of a competitive enzyme-linked immunosorbent assay for therapeutic drug monitoring of afatinib. Journal of Pharmaceutical Analysis, 9(1), 49-54.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!