In this study, we collected 200 bone scan images from the Department of Nuclear Medicine of China Medical University Hospital. The details of the bone scan images are provided in Table 1 . Specifically, D1 is defined as 90 images from breast cancer patients with bone metastasis. D2 is defined as 10 images from breast cancer patients without bone metastasis. D3 is defined as 50 images from prostate cancer patients with bone metastasis. D4 is defined as 50 images from prostate cancer patients without bone metastasis. Figure 1 shows bone scan images of breast cancer patients. This study has been approved by the Institutional Review Board (IRB) of China Medical University and Hospital Research Ethics Committee (CMUH106-REC2-130), approved on 27 September 2017.
The WBBS process can be described as follows. Patients undergo WBBS with a gamma camera (Millennium MG, Infinia Hawkeye 4, or Discovery NM/CT 670 system; GE Healthcare, Waukesha, WI, USA). Bone scans are acquired 2–4 h after the intravenous injection of 740–925 MBq (20–25 mCi) of technetium-99m methylene diphosphonate (Tc-99m MDP) with an acquisition time of 10–15 cm/min. The collected WBBS images are saved in DICOM format. The raw images include anterior–posterior (AP) and posterior–anterior (PA) views, with a matrix size of 1024 × 256 pixels.
The WBBS process can be described as follows. Patients undergo WBBS with a gamma camera (Millennium MG, Infinia Hawkeye 4, or Discovery NM/CT 670 system; GE Healthcare, Waukesha, WI, USA). Bone scans are acquired 2–4 h after the intravenous injection of 740–925 MBq (20–25 mCi) of technetium-99m methylene diphosphonate (Tc-99m MDP) with an acquisition time of 10–15 cm/min. The collected WBBS images are saved in DICOM format. The raw images include anterior–posterior (AP) and posterior–anterior (PA) views, with a matrix size of 1024 × 256 pixels.