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Medspec biospin

Manufactured by Bruker

The MedSpec Biospin is a laboratory equipment product offered by Bruker. It is designed for magnetic resonance imaging (MRI) and spectroscopy applications. The core function of the MedSpec Biospin is to provide a platform for conducting MRI and spectroscopy analyses.

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3 protocols using medspec biospin

1

Functional and Structural MRI Imaging

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Functional and structural data were collected using a 4 T Bruker MedSpec Biospin MR scanner and an eight-channel birdcage head coil. Functional images were acquired with a T2*-weighted gradient echo-planar imaging (EPI) sequence with fat suppression. Acquisition parameters were a repetition time (TR) of 2.2 s, an echo time of 33 ms, a flip angle (FA) of 75°, a field of view (FOV) of 192 mm, a matrix size of 64 × 64, and a voxel resolution of 3 × 3 × 3 mm. We used 31 slices, acquired in ascending interleaved order, with a thickness of 3 mm and 15% gap (0.45 mm). Slices were tilted to run parallel to the superior temporal sulcus. In each functional run, 176 images were acquired. Before each run, we performed an additional scan to measure the point-spread function (PSF) of the acquired sequence to correct the distortion expected with high-field imaging56 (link).
Structural T1-weigthed images were acquired with an MPRAGE sequence (176 sagittal slices, TR = 2.7 s, inversion time = 1020 ms, FA = 7°, 256 × 224 mm FOV, 1 × 1 × 1 mm resolution).
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2

Structural and Functional MRI Acquisition

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Scanning was performed on a 4-T Bruker MedSpec Biospin MRI scanner with an eight-channel phase-array receiver head coil. To make sure the participants fit comfortably inside the scanner during the experiment, we fixed their heads with foam cushions to minimize head movement. The T1-weighted high-resolution anatomical images were acquired using a sagittal magnetization-prepared rapid gradient echo (MP-RAGE) three-dimensional T1-weighted sequence optimized for grey-white matter contrast (repetition time [TR] = 2700 ms, echo time [TE] = 4.18 ms, inversion time [TI] = 1020 ms, flip angle [FA] = 7°, slice number = 176, and matrix size = 224 × 256, 1 × 1 × 1 mm3, GRAPPA iPAT = 2). The functional images were acquired using an echo-planar (EPI) sequence corrected for distortion using the PSF method (TR = 2500 ms, TE = 33 ms, FA = 73°, 34 slices, 3 × 3 × 3 mm voxels, field of view [FOV] = 192).
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3

Resting-state fMRI Acquisition and T1-weighted Imaging

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Imaging data were acquired using a 4 T Bruker MedSpec Biospin MR scanner with a birdcage transmit and 8-channel receive head radiofrequency coil. For the resting-state functional connectivity (rs-fMRI) acquisition participants were instructed to lay still, with their eyes closed and to think of nothing in particular. The scanning duration of the rs-fMRI was approximately 8 min (215 volumes). Rs-fMRI images were acquired with a single shot T2*-weighted gradient-recalled echo-planar imaging (EPI) sequence (TR = 2,200 ms, voxel resolution = 3 × 3 × 3  mm3, TE = 33 ms, FA = 75°, FOV = 192 × 192  mm2; slice gap, 0.4 mm).
Moreover, a structural T1- weighted anatomical scan was acquired (MP-RAGE; 1 × 1 × 1  mm3; FOV, 256 × 224 mm2; 176 slices; GRAPPA acquisition with an acceleration factor of 2; TR, 2,700 ms; TE, 4.18 ms; inversion time (TI), 1,020 ms; 7° flip angle).
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