Male Wistar outbred rats (4 weeks old, 85–95 g) were obtained from Charles River (Sulzfeld, Germany). They were housed in individual Plexiglas cages under controlled temperature and humidity, and a 12–12 h light–dark cycle (7.00 am –7.00 pm ). AIN93G diet [5 (link), 18 (link)] and water were available ad libitum. The study protocol was approved by the Ethics committee for Animal experiments, Faculty of Medical Sciences, University of Groningen, The Netherlands.
Male wistar outbred rats
Manufactured by Charles River Laboratories
Sourced in Germany
Male Wistar outbred rats are a common laboratory animal model used in research. They are a general-purpose rat strain that are widely used across various fields of study. The core function of these rats is to serve as biological subjects for scientific investigations and experiments.
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2 protocols using male wistar outbred rats
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Male Wistar Rats Housing and Diet
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GBCA Neurotoxicity in Wistar Rats
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Male Wistar out-bred rats (obtained from Charles River, Sulzfeld—Germany) were repeatedly injected intravenously on four consecutive days per week for two weeks either with saline (n = 40) or with the GBCA gadobutrol or gadodiamide at three different body surface adjusted doses of either 0.6, 1.2 or 1.8 mmol/kg BW, representing the recommended clinical single-, double- or triple dose (n = 20 for each dose and GBCA).
The same dosing regimen (8 × 1.8 mmol/kg BW or saline) was applied for the subcellular fractionation experiments. Rats (n = 6 per group and time point) were sacrificed at day 4, 5 weeks and after 1 year. For the subcellular fractionation of brain tissue early after GBCA administration, rats received a single dose of 1.8 mmol/kg BW or saline and were sacrificed 6 h and 24 h after GBCA injection.
The same dosing regimen (8 × 1.8 mmol/kg BW or saline) was applied for the subcellular fractionation experiments. Rats (n = 6 per group and time point) were sacrificed at day 4, 5 weeks and after 1 year. For the subcellular fractionation of brain tissue early after GBCA administration, rats received a single dose of 1.8 mmol/kg BW or saline and were sacrificed 6 h and 24 h after GBCA injection.
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