Automated glycohemoglobin analyzer hlc 723g8

Manufactured by Tosoh

Sourced in Japan

The Automated Glycohemoglobin Analyzer HLC-723G8 is a laboratory instrument designed to measure glycohemoglobin levels. It provides an automated and precise method for the quantitative determination of glycohemoglobin in human whole blood samples.

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28 protocols using automated glycohemoglobin analyzer hlc 723g8

Comprehensive Metabolic and Hematological Profiling

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BMI was calculated by height and weight (weight divided by height squared, kg/m²). Systolic and diastolic blood pressure (SBP, DBP) were measured using digital sphygmomanometer with a standard protocol. All blood samples were collected in the morning (7–8 a.m.) after a 10–12 h overnight fast. Serum samples (centrifugation: 3000g for 5 min) or whole blood samples were used as required for subsequent tests.
Serum levels of fasting blood glucose (FBG), triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alanine aminotransferase(ALT), aspartate aminotransferase (AST), urea nitrogen (Urea), creatinine (Crea), uric acid (UA), nonesterified fatty acid (NEFA) were all examined by HITACHI7600 automatic analyzer (Hitachi Ltd, Japan). Whole blood level of HbA1c was measured by Tosoh Automated Glycohemoglobin Analyzer HLC-723 G8 (Tosoh Corporation, Japan) and several parameters of blood routine (i.e. white blood cell, neutrophil, eosnophils) were measured by Sysmex XN-20 automated hematology analyzer (Sysmex Corporation, Japan). The relevant information of the methods of above parameters see in Additional file 1: Table S1 and all indexes were measured under standardized conditions in an ISO 15189 accredited medical laboratory [29 (link)].

Tang H., Liu N., Feng X., Yang Y., Fang Y., Zhuang S., Dai Y., Liu M, & Tang L. (2021). Circulating levels of IL-33 are elevated by obesity and positively correlated with metabolic disorders in Chinese adults. Journal of Translational Medicine, 19, 52.

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Comprehensive Metabolic Panel Analysis

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Plasma alanine aminotransferase (ALT), gamma‐glutamyltransferase (GGT), aspartate aminotransferase (AST), plasma‐glucose, low‐density lipoproteins (LDLs), very low‐density lipoproteins (VLDLs), high‐density lipoproteins (HDLs), and triglycerides were measured using the Roche/Hitachi Cobas c 8000 system (Roche Diagnostics GmbH, Mannheim, Germany) and Cobas calibrators and reagents according to the manufacturer’s instructions. Serum insulin and C‐peptide concentrations were measured by immunoassay with the Cobas e 602.
Hemoglobin A1c (HbA1c) was measured in plasma with the Tosoh TSKgel G8 Variant His on the Tosoh Automated Glycohemoglobin Analyzer HLC‐723G8 (Tosoh Corporation, Tokyo, Japan)

Pedersen J.S., Rygg M.O., Kristiansen V.B., Olsen B.H., Serizawa R.R., Holst J.J., Madsbad S., Gluud L.L., Bendtsen F, & Wewer Albrechtsen N.J. (2020). Nonalcoholic Fatty Liver Disease Impairs the Liver–Alpha Cell Axis Independent of Hepatic Inflammation and Fibrosis. Hepatology Communications, 4(11), 1610-1623.

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Routine Metabolic and Liver Markers

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Routine metabolic and liver markers were analysed immediately after blood sampling. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), plasma-glucose and triglycerides were measured using the Roche/Hitachi Cobas c 8000 system (Roche Diagnostics GmbH, Mannheim, Germany) with Cobas calibrators and reagents, according to the manufacturer’s instructions. Serum insulin and c-peptide concentrations were measured by immunoassay Cobas e 602. HbA1c was measured in plasma with the Tosoh TSKgel G8 Variant His on the Tosoh Automated Glycohemoglobin Analyzer HLC-723G8 (Tosoh Corporation, Tokyo, Japan). All markers were measured in the fasting state.

Pedersen J.S., Rygg M.O., Chrøis K., Sustarsic E.G., Gerhart-Hines Z., Wever Albrechtsen N.J., Serizawa R.R., Kristiansen V.B., Basse A.L., Boilesen A.E., Olsen B.H., Hansen T., Gluud L.L., Madsbad S., Larsen S., Bendtsen F, & Dela F. (2022). Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. Nature Communications, 13, 2931.

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Measuring Obesity and Glycemic Markers

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Obesity was measured by BMI as well as by truncal fat mass. BMI is calculated as body weight in kilograms divided by height squared in meters. Dual-energy x-ray absorptiometry (DXA) (Hologic Horizon APEX Software 5.5.2) provided a measure of truncal fat mass. The trunk was defined as the region above the iliac crests and below the inferior aspect of the mandible after exclusion of the upper extremities. Percentage fat by DXA was also measured, but not added to the model, given its collinearity with BMI and truncal fat, its lower specificity than truncal fat for predicting obesity complications (13 (link)), and its limited use in clinical practice when compared to BMI. The A1c was measured using Tosoh Automated Glycohemoglobin Analyzer (HLC-723G8, Tosoh Bioscience, Inc, San Francisco, CA).

Heisey H.D., Kunik M.E., Qualls C., Segoviano-Escobar M.B, & Villareal D.T. (2022). Truncal fat and frailty are important predictors of cognitive performance among aging adults with obesity. The journal of nutrition, health & aging, 26(5), 425-429.

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Glycemic Control Assessment Protocol

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Blood HbA1c was determined with high-performance liquid chromatography (HPLC) (Automated Glycohemoglobin Analyzer HLC-723 G8; Tosoh^® Bioscience Company, Tokyo, Japan) to reflect patients’ current level of glycemic control, categorized as good (HbA1c ≤ 7.0% (≤ 53 mmol/mol), moderate [7.1–8.0% (54–64 mmol/mol)], poor [8.1–9.0% (65–75 mmol/mol)] or very poor [> 9% (> 75 mmol/mol)]. Mean and standard deviation (SD) of 10-years HbA1c history was collected to reflect patients’ long-term glycemic exposure and variability, respectively, provided that at least sixteen HbA1c values were available for the 10-year period and with a maximum of one year without HbA1c.

Helleputte S., Calders P., Rodenbach A., Marlier J., Verroken C., De Backer T, & Lapauw B. (2022). Time-varying parameters of glycemic control and glycation in relation to arterial stiffness in patients with type 1 diabetes. Cardiovascular Diabetology, 21, 277.

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Fasting Plasma Glucose and HbA1c Measurement

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Fasting blood sample was collected within 24 h on admission prior to angiography. The blood samples were collected into EDTA-anticoagulant tubes and centrifuged to obtain the plasma. Enzymatic hexokinase method was used to measure the concentrations of blood glucose. Tosoh Automated Glycohemoglobin Analyzer (HLC-723G8) was used to measure the HbA1c levels. All other laboratory measurements were performed at the biochemistry center of Fuwai Hospital by standard biochemical techniques.

Song C., Yuan S., Cui K., Cai Z., Zhang R., He J., Qiao Z., Bian X., Wu S., Wang H., Shi B., Lin Z., Fu R., Wang C., Liu Q., Jia L., Dong Q, & Dou K. (2023). HbA1c-based rather than fasting plasma glucose-based definitions of prediabetes identifies high-risk patients with angiographic coronary intermediate lesions: a prospective cohort study. Cardiovascular Diabetology, 22, 68.

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Fasting Blood Biomarkers in Patients

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Fasting blood samples were drawn from all patients within 24 h after admission. Enzymatic hexokinase method was used to measure the concentrations of blood glucose. Tosoh Automated Glycohemoglobin Analyzer (HLC-723G8) was used to measure the HbA1c levels. Stago autoanalyzer with the STA fibrinogen kit (Diagnostica Stago, Taverny, France) was used to measure the concentrations of FIB. All other laboratory measurements were conducted at the biochemistry center of Fu Wai Hospital by standard biochemical techniques.

Yuan D., Jiang P., Zhu P., Jia S., Zhang C., Liu Y., Liu R., Xu J., Tang X., Zhao X., Gao R., Yang Y., Xu B., Gao Z, & Yuan J. (2021). Prognostic value of fibrinogen in patients with coronary artery disease and prediabetes or diabetes following percutaneous coronary intervention: 5-year findings from a large cohort study. Cardiovascular Diabetology, 20, 143.

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Lipid and Glycemic Biomarker Measurement

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Blood samples were obtained from the cubital vein after at least 12 h of fasting in the current study. Concentrations of TC, TG, low density lipoprotein cholesterol (LDL-C), HDL-C levels were measured with an automatic biochemistry analyzer (7150; Hitachi, Tokyo, Japan) in an enzymatic assay. Apolipoprotein AI (apo AI), and apo B were measured by an immunoturbidimetric method (Tina-quant, Roche Diagnostics). Lp(a) was determined by immunoturbidimetry method [LASAY Lp(a) auto; SHIMA Laboratories Co., Ltd] with a normal value of < 30 mg/dL. An Lp(a) protein validated standard was used to calibrate the examination, and the coefficient of variation value of repetitive measurements was < 10%. The concentrations of glucose were measured by enzymatic hexokinase method, and HbA1c by a Tosoh Automated Glycohemoglobin Analyzer HLC-723G8.

Zhang Y., Jin J.L., Cao Y.X., Zhang H.W., Guo Y.L., Wu N.Q., Zhu C.G., Gao Y., Hua Q., Li Y.F., Xu R.X, & Li J.J. (2020). Lipoprotein (a) predicts recurrent worse outcomes in type 2 diabetes mellitus patients with prior cardiovascular events: a prospective, observational cohort study. Cardiovascular Diabetology, 19, 111.

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Comprehensive Metabolic Profile Analysis

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The measurement of lipid components levels, including triglycerides, total cholesterol, high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) was performed using an automatic biochemical Cobas 6000 Chemistry Analyzer Series (Roche Diagnostics GmbH, Germany). Insulin levels were measured using the Cobas 8000 Modular Analyzer Series (Roche Diagnostics GmbH) based on the electrochemical immune fluorescence method. The concentrations of fasting blood glucose were quantified by ultraviolet measurement with hexokinase. The blood fasting glycosylated hemoglobin (HbA1c) levels were measured by the Tosoh Automated Glycohemoglobin Analyzer HLC-723G8 (Tosoh, Japan) through the ion-exchange method using high-performance liquid chromatography. The homeostasis model assessment insulin resistance (HOMA-IR) index was calculated according to Matthews' method: HOMA-IR = glucose × insulin / 22.5 (29 (link)).

Mai N.T., Hang N.T., Hanh D.H., Le H.Y., Hinh N.V., Ky N.D., Tuan N.M., Tong H.V., Quan D.T, & Toan N.L. (2023). Leptin and interleukin-1β levels associated with osteoarthritis in Vietnamese patients: a cross-sectional analysis. Brazilian Journal of Medical and Biological Research, 56, e12746.

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Comprehensive Metabolic Profiling in Admissions

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Fasting blood samples were routinely drawn from each patient on the day of admission and all of them were stored in − 80 °C refrigerators until test. Complete blood count including WBC, neutrophil, lymphocyte, and other parameters was carried out using an automatic blood cell analyzer (XT-1800i; Sysmex Corporation) [23 (link)]. The HbA1c levels were measured by Tosoh Automated Glycohemoglobin Analyzer (HLC-723G8, Tokyo, Japan) [20 (link)]. Other laboratory parameters, including lipid profiles (TG, TC, HDL-C and LDL-C), eGFR, creatinine, high-sensitivity CRP (hsCRP) were examined at the core laboratory in Fuwai hospital, according to the standard operating procedures [20 (link)]. The eGFR was calculated using the Chinese-modified MDRD (Modification of Diet in Renal Disease) equation [25 (link)]. Based on modified Simpson’s rule, left ventricular ejection fraction (LVEF) was estimated from two-dimensional echocardiography.

He J., Bian X., Song C., Zhang R., Yuan S., Yin D, & Dou K. (2022). High neutrophil to lymphocyte ratio with type 2 diabetes mellitus predicts poor prognosis in patients undergoing percutaneous coronary intervention: a large-scale cohort study. Cardiovascular Diabetology, 21, 156.

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