Log In Sign up
The largest database of trusted experimental protocols

Cd19cre cre

Manufactured by Jackson ImmunoResearch
Visit Supplier
Sourced in United States

The Cd19cre/cre is a laboratory mouse model that expresses Cre recombinase under the control of the Cd19 gene promoter. This allows for the targeted deletion or modification of gene sequences in B cells.

Automatically generated - may contain errors

Lab products found in correlation

P53fl fl, by Jackson ImmunoResearch (2 mentions) Cd21 cre, by Jackson ImmunoResearch (2 mentions) C57bl 6j, by Jackson ImmunoResearch (2 mentions) C57bl 6 ly5, by Jackson ImmunoResearch (1 mentions) C3h hen, by CLEA Japan (1 mentions) C3h hej, by CLEA Japan (1 mentions) C57bl 6j, by CLEA Japan (1 mentions) B6.129p2 c cd19tm1 cre cgn j mice, by Jackson ImmunoResearch (1 mentions)

4 protocols using cd19cre cre

1

Mice Strains for Immunological Research

Check if the same lab product or an alternative is used in the 5 most similar protocols
C57BL/6J, C3H/HeJ and C3H/HeN mice were purchased from Clea Japan (Tokyo, Japan). The genetic background of the genetically engineered mice used was C57BL/6J. Il6−/− (IL-6-KO), Cd19-Cre, Jh−/− (Jh-KO) and C57BL/6-Ly5.1 mice were purchased from Jackson Laboratory (Bar Harbor, ME, USA); mice with homozygous Cd19 deficiency (Cd19cre/cre) were used as Cd19−/− mice. Myd88−/− (Myd88-KO), Ticam−/− (Trif-KO) and Tlr4−/− (TLR4-KO) mice were purchased from Oriental BioService (Kyoto, Japan). Fcα/μR−/− (Fcα/μR-KO) mice were generated in our laboratory, as previously described, and backcrossed onto the C57BL/6 genetic background for 12 generations. Only female mice between the ages of 8 weeks and 12 weeks were used for the experiments. All experiments were performed in accordance with the guidelines of the animal ethics committee of the University of Tsukuba Animal Research Center.
Honda S.I., Sato K., Totsuka N., Fujiyama S., Fujimoto M., Miyake K., Nakahashi-Oda C., Tahara-Hanaoka S., Shibuya K, & Shibuya A. (2016). Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling. Nature Communications, 7, 11498.
+ Open protocol
+ Expand
2

Mouse Genetic Strains for Immunology Research

Cited 1 time
Check if the same lab product or an alternative is used in the 5 most similar protocols
Aicda−/− (Muramatsu et al., 2000 (link)), Mb1cre/cre (Hobeika et al., 2006 (link)) and Vav-Bcl2 (Egle et al., 2004 (link)) mice were respectively, kindly provided by Tasuku Honjo (University of Kyoto, Japan), Alexander Tarakhovsky (Rockefeller University, USA) and Ari Melnick (Weill Cornell Medical School). Aicdacre/cre mice (Robbiani et al., 2008 (link)) were obtained from the Nussenzweig lab (Rockefeller University,USA). Generation of Chd4fl/fl mice was described previously (Williams et al., 2004 (link)). Cd19cre/cre, Cd21cre, p53fl/fl and C57BL/6J were purchased from the Jackson Laboratories (Bar Harbor, ME). 8–16 week old mice of both sexes were used and whenever possible littermates were used as controls. Mice used in the experiments were maintained in specific pathogen free conditions in Memorial Sloan Kettering Cancer Center vivarium according to the institutional guidelines.
Yen W.F., Sharma R., Cols M., Lau C.M., Chaudhry A., Chowdhury P., Yewdell W.T., Vaidyanathan B., Sun A., Coffre M., Pucella J.N., Chen C.C., Jasin M., Sun J.C., Rudensky A.Y., Koralov S.B, & Chaudhuri J. (2019). Distinct Requirements of CHD4 during B Cell Development and Antibody Response. Cell reports, 27(5), 1472-1486.e5.
+ Open protocol
+ Expand
3

Mouse Genetic Strains for Immunology Research

Cited 1 time
Check if the same lab product or an alternative is used in the 5 most similar protocols
Aicda−/− (Muramatsu et al., 2000 (link)), Mb1cre/cre (Hobeika et al., 2006 (link)) and Vav-Bcl2 (Egle et al., 2004 (link)) mice were respectively, kindly provided by Tasuku Honjo (University of Kyoto, Japan), Alexander Tarakhovsky (Rockefeller University, USA) and Ari Melnick (Weill Cornell Medical School). Aicdacre/cre mice (Robbiani et al., 2008 (link)) were obtained from the Nussenzweig lab (Rockefeller University,USA). Generation of Chd4fl/fl mice was described previously (Williams et al., 2004 (link)). Cd19cre/cre, Cd21cre, p53fl/fl and C57BL/6J were purchased from the Jackson Laboratories (Bar Harbor, ME). 8–16 week old mice of both sexes were used and whenever possible littermates were used as controls. Mice used in the experiments were maintained in specific pathogen free conditions in Memorial Sloan Kettering Cancer Center vivarium according to the institutional guidelines.
Yen W.F., Sharma R., Cols M., Lau C.M., Chaudhry A., Chowdhury P., Yewdell W.T., Vaidyanathan B., Sun A., Coffre M., Pucella J.N., Chen C.C., Jasin M., Sun J.C., Rudensky A.Y., Koralov S.B, & Chaudhuri J. (2019). Distinct Requirements of CHD4 during B Cell Development and Antibody Response. Cell reports, 27(5), 1472-1486.e5.
+ Open protocol
+ Expand
4

Conditional TGF-β1 Deletion in B Cells

Check if the same lab product or an alternative is used in the 5 most similar protocols
WT C57BL/6J CD45.1, OT-II mice, TGF-β1−/− (Tgfb1tm2.1Doe/J), and CD19cre/cre (homozygous for cre cassette, B6.129P2(C)-Cd19tm1(cre)Cgn/J) mice were purchased from the Jackson Laboratories (Bar Harbor). For selective deletion of floxed TGF-β1 gene in B lymphocytes, CD19cre/cre mice were crossed with TGF-β1flox/flox mice. Litters heterozygous for the cre cassette (CD19cre-TGF-β1flox/flox) (B–TGF-β1−/−) and TGF-β1flox/flox (B–TGF-β1+/+) mice were used for experiments. Animals were housed in a specific pathogen-free barrier facility at the Medical Center of Geneva, Faculty of Medicine (Geneva, Switzerland). All breeding and experimental protocols and procedures were reviewed and approved by the Institutional Animal Care and Use Committee of the Geneva University School of Medicine (protocol number: GE/107/15). Animal care and experimental procedures were carried out in accordance with the guidelines of the Institutional Animal Care and Use Committee of the Geneva University School of Medicine.
Bjarnadóttir K., Benkhoucha M., Merkler D., Weber M.S., Payne N.L., Bernard C.C., Molnarfi N, & Lalive P.H. (2016). B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation. Scientific Reports, 6, 34594.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!