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Arv 771

Manufactured by Selleck Chemicals
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Sourced in United States

ARV-771 is a laboratory product manufactured by Selleck Chemicals. It is a small-molecule inhibitor. Further details regarding its core function or intended use are not available.

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Lab products found in correlation

Anti skp2, by Cell Signaling Technology (1 mentions) Anti gapdh, by Cell Signaling Technology (1 mentions) Sorafenib, by Selleck Chemicals (1 mentions) Anti ubiquitin, by Cell Signaling Technology (1 mentions) Ly3214996, by Selleck Chemicals (1 mentions) Anti usp15, by Cell Signaling Technology (1 mentions) Anti six1, by Cell Signaling Technology (1 mentions) Anti k48 linked ubiquitin, by Cell Signaling Technology (1 mentions) Anti p jnk, by Cell Signaling Technology (1 mentions) Anti mek, by Cell Signaling Technology (1 mentions) Anti p mek, by Cell Signaling Technology (1 mentions) Sp600125, by Selleck Chemicals (1 mentions) Anti jnk, by Cell Signaling Technology (1 mentions) Anti parp, by Cell Signaling Technology (1 mentions) Rpmi 1640, by Thermo Fisher Scientific (1 mentions) High glucose dmem, by Thermo Fisher Scientific (1 mentions) Matrigel, by Corning (1 mentions) Polyethylenimine (pei), by Merck Group (1 mentions) Glutamine, by Thermo Fisher Scientific (1 mentions) Doxycycline, by Merck Group (1 mentions)

4 protocols using arv 771

1

Comprehensive Signaling Pathway Analysis

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ARV-771 (S8532), LY3214996 (S8534), SB230580 (S1076), SP600125 (S1460), and sorafenib (S7397) were obtained from Selleckchem (Houston, TX). Anti-CDK4 (ab108357), anti-CDK6 (ab124821), anti-Cyclin D1 (ab16663), anti-p27 (ab32034), anti-Bcl-2 (ab32124), anti-Bcl-XL (ab32370), anti-BRD2 (ab139690), anti-BRD3 (ab50818), anti-BRD4 (ab128874), anti-USP5 (ab154170), anti-USP7 (ab108931), anti-USP8 (ab228572), anti-USP9X (ab19879), anti-USP10 (ab109291), anti-USP13 (ab109624), anti-USP18 (ab168478), anti-USP39 (ab131244), anti-USP14 (ab235960), anti-UCH37 (ab133508), anti-p-ERK (ab32538), anti-ERK (ab184699), anti-p-p38 (ab4822), and anti-p38 (ab170099) were obtained from Abcam (Cambridge, MA). Anti-PARP (#9532), anti-USP1 (#8033), anti-USP15 (#66310), anti-STAMBP (#5245), anti-K48-linked ubiquitin (#12805), anti-ubiquitin (#3936), anti-SIX1 (#16960), anti-SKP2 (#2652), anti-GAPDH (#5174), anti-p-MEK (#3958), anti-MEK (#4694), anti-p-JNK (#9255), and anti-JNK (#9252) were purchased from Cell Signaling Technology (Beverly, MA).
Deng Y., Yu C., Chen L., Zhang X., Lei Q., Liu Q., Cai G, & Liu F. (2022). ARV-771 Acts as an Inducer of Cell Cycle Arrest and Apoptosis to Suppress Hepatocellular Carcinoma Progression. Frontiers in Pharmacology, 13, 858901.
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2

Compound Acquisition and Preparation

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Compounds ARV-771 and JQ1 were purchased from Selleckchem (Houston TX, USA) and MZ1 has been obtained from Boehringer-Ingelheim (openME, Ingelheim, Germany). All compounds were used as 10 mM stock solutions in dimethyl sulfoxide (DMSO).
Teufelsbauer M., Stickler S., Eggerstorfer M.T., Hammond D.C, & Hamilton G. (2024). BET-directed PROTACs in triple negative breast cancer cell lines MDA-MB-231 and MDA-MB-436. Breast cancer research and treatment.
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3

Comprehensive Cell Culture Toolkit

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DMEM High Glucose (Gibco), RPMI 1640 (Gibco), Trypsin 0.05% (Gibco), penicillin/streptomycin 1X (Gibco), Glutamine (Gibco), Matrigel (Corning), Polybrene (Santa Cruz Biotechnology), Polyethylenimine (Sigma-Aldrich), BRD2 antibody (Bethyl Laboratories), β-actin (Cell Signaling Technology), Osimertinib (MedchemExpress, Selleck), CID compound (Takara 635088), Doxycycline (Sigma), Alisertib (Selleck), Trametinib (Medko), Dabrafenib (MedchemExpress), Crizotinib (Selleck), AMG510 (Selleck), RSL3(Selleck), NEO2734(Selleck), ARV-771(Selleck), CC90010 (Selleck), ABT-263 (Selleck), Ferrostatin (Selleck), Z-VAD-FMK (Selleck), N-acetylcysteine amide (Sigma).
Chen M., Mainardi S., Lieftink C., Velds A., de Rink I., Yang C., Kuiken H.J., Morris B., Edwards F., Jochems F., van Tellingen O., Boeije M., Proost N., Jansen R.A., Qin S., Jin H., Koen van der Mijn J.C., Schepers A., Venkatesan S., Qin W., Beijersbergen R.L., Wang L, & Bernards R. (2024). Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse. Cell Reports Medicine, 5(3), 101471.
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4

Evaluating Epigenetic Modulators In Vitro and In Vivo

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JQ1 was a generous gift from Jun Qi (Dana-Farber Cancer Institute, Boston, MA, USA). ARV-771 and BMS-986158 were obtained from Selleck Chem (#S8532, #S9691). For in vitro studies, compounds were resuspended in DMSO. For the in vivo study, BMS-986158 was formulated by adding 10% DMSO, 40% PEG300, 5% Tween-80, and 45% saline, in that order.
Chin D.H., Osman I., Porch J., Kim H., Buck K.K., Rodriguez J., Carapia B., Yan D., Moura S.B., Sperry J., Nakashima J., Altman K., Altman D, & Gryder B.E. (2023). BET Bromodomain Degradation Disrupts Function but Not 3D Formation of RNA Pol2 Clusters. Pharmaceuticals, 16(2), 199.
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