Sanbetason

Manufactured by Santen

Sourced in Japan

Sanbetason is a laboratory equipment product manufactured by Santen. It is designed for specific laboratory applications. The core function of Sanbetason is to assist in controlled experimental procedures, but a detailed description cannot be provided while maintaining an unbiased and factual approach.

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Lab products found in correlation

Cravit, by Santen (3 mentions) Levofloxacin, by Santen (3 mentions) Sanpilo, by Santen (1 mentions) Tarivid, by Santen (1 mentions) Wj 60m, by Santen (1 mentions)

5 protocols using sanbetason

Postoperative Management for Standardized DMEK

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In the staged group, patients were administered 1.5% levofloxacin (Cravit; Santen, Osaka, Japan) and betamethasone (Sanbetason; Santen) 4 times daily and bromfenac (Bronuck; Senju Pharmaceutical Co, Osaka, Japan) 2 times daily between cataract surgery and the DMEK procedure.
Standardized DMEK was performed as previously reported.^{10 (link),11 (link)} After surgery, 0.4 mg of betamethasone (Rinderon; Shionogi, Osaka, Japan) was injected subconjunctivally and 1.5% levofloxacin eye drops (Cravit; Santen) were instilled. Two hours after completing surgery, slit-lamp examination was conducted and intraocular pressure was checked. All patients were instructed to remain supine for several days until the air in the anterior chamber (AC) had disappeared. Postoperative medications included 1.5% levofloxacin (Cravit; Santen) and betamethasone (Sanbetason; Santen) 4 times daily for 3 months and tapered thereafter. Topical tropicamide was not included in the postoperative regimen.
When CME was diagnosed postoperatively, topical bromfenac (Bronuck; Senju Pharmaceutical Co) and a sub-Tenon injection of triamcinolone acetonide (MaQaid; Wakamoto Pharmaceutical Co, Tokyo, Japan) were immediately applied and administered, respectively. After cataract surgery, postoperative medications included topical bromfenac as well as 1.5% levofloxacin and betamethasone.

Inoda S., Hayashi T., Takahashi H., Oyakawa I., Yokogawa H., Kobayashi A., Kato N, & Kawashima H. (2019). Risk Factors for Cystoid Macular Edema After Descemet Membrane Endothelial Keratoplasty. Cornea, 38(7), 820-824.

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Postoperative Care for Glaucoma Patients

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Postoperative care included 0.5% levofloxacin drops (Cravit, Santen Pharmaceutical Co., Ltd.) and 0.1% betamethasone sodium phosphate eye drops (Sanbetason, Santen Pharmaceutical Co., Ltd.) 3 times a day for 1 month. Patients were instructed to restart the same preoperatively used glaucoma medications 1 day postoperatively. Thus, the patient's preoperative ocular hypotensive eye drop regimen was maintained throughout the study period.
Follow-up visits occurred at 1 day, 1 week, and at 1, 2, 3, and 6 months. Examinations performed at each of these follow-up visits included slit-lamp examination, gonioscopy, and measurement of the IOP. In addition, specular microscopy was performed at 1, 3, and 6 months, while the BCVA was checked at 1 day, 1 week, and 1 and 6 months.

Shiba D., Hosoda S., Yaguchi S., Ozeki N., Yuki K, & Tsubota K. (2017). Safety and Efficacy of Two Trabecular Micro-Bypass Stents as the Sole Procedure in Japanese Patients with Medically Uncontrolled Primary Open-Angle Glaucoma: A Pilot Case Series. Journal of Ophthalmology, 2017, 9605461.

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Microhook-Assisted Gonioscopic Trabeculotomy

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A standard surgical procedure was performed with microhooks during µLOT. A Swan-Jacob gonioprism lens (Ocular Instruments, Inc., Bellevue, WA) was used to observe the angle opposite to the corneal port, and the microhook was inserted into the anterior chamber through the corneal port. The microhook tip then was inserted into Schlemm’s canal and moved circumferentially to incise the inner wall of the canal and TM over 90-degree extents; this also was performed on the opposite side. For postoperative eye drops,1.5% levofloxacin (Nipro, Osaka, Japan) and 0.1% betamethasone (Sanbetason, Santen Pharmaceutical) are applied topically 4 times daily for 3–4 weeks in all cases. Miotic ophthalmic solutions are not used postoperatively.16 Regarding the clinical records, all subjects had undergone successful standard µLOT procedures, and the incisions were created that extended from 180 to 240 degrees, with at least the following sectors of the TM incised: the superotemporal (ST) to superotemporal-temporal (STT)∼inferotemporal (IT) to inferoinferior-temporal (IIT) and inferoinferior nasal (IIN) to inferonasal (IN)∼superonasal-nasal (SNN) to superonasal (SN). Therefore, eight images of the STT, T, ITT, IT, IN, INN, N, and SNN sectors were included in the extend of the µLOT incisions (Figure 1B).

Matsuo M., Inomata Y., Kozuki N, & Tanito M. (2021). Characterization of Peripheral Anterior Synechiae Formation After Microhook Ab-interno Trabeculotomy Using a 360-Degree Gonio-Camera. Clinical Ophthalmology (Auckland, N.Z.), 15, 1629-1638.

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Standardized Ophthalmic Surgery Protocol

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All surgeries were performed under miosis induced by topical 1% pilocarpine (Sanpilo; Santen Pharmaceutical, Osaka, Japan) and standard sub-Tenon anesthesia using 2% lidocaine. At the end of surgery, 1.65 mg of dexamethasone sodium phosphate (Decadron; Aspen Japan, Tokyo, Japan) was injected subconjunctivally and 0.3% ofloxacin ointment (Tarivid; Santen Pharmaceutical) was applied. Finally, 1.5% levofloxacin (Nipro, Osaka, Japan) and 0.1% betamethasone (Sanbetason; Santen Pharmaceutical) were applied topically four times daily for 3–4 weeks postoperatively in all cases.

Tanito M., Matsuzaki Y., Ikeda Y, & Fujihara E. (2017). Comparison of surgically induced astigmatism following different glaucoma operations. Clinical Ophthalmology (Auckland, N.Z.), 11, 2113-2120.

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Experienced Surgeon Performs DMEK Procedure

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All DMEK procedures were performed by the same experienced surgeon (TH), as previously described in literature^{37 (link),38 (link)}. Briefly, a pre-stripped donor tissue was punched for the estimated size (approximately 8.0-mm) with asymmetric semicircular marks on a vacuum punch (Moria Japan, Tokyo, Japan) stained with 0.1% Brilliant Blue G dye^{37 (link),38 (link)}. After removing the host’s Descemet membrane under air infusion, a DMEK graft was implanted using an IOL inserter (WJ-60M; Santen, Osaka, Japan) into the anterior chamber via a 2.8-mm-corneoscleral tunnel; it was then unfolded, and fixed with 20% SF6 gas. Peripheral iridectomy was performed at the 6 o’ clock position using a 25-gauge vitreous cutter (Stellaris PC Vitrectomy system; Bausch & Lomb, St. Louis, MO, USA).
At the end of the surgery, a subconjunctival injection of 0.4 mg of betamethasone (Rinderon; Shionogi, Osaka, Japan) was administered. Two hours after surgery, slit-lamp examination was performed. All patients were instructed to maintain the supine position for several days. Postoperative medications included a combination of 1.5% levofloxacin (Cravit; Santen), betamethasone (Sanbetason; Santen), and 2% rebamipide ophthalmic solution (Mucosta; Otsuka, Tokyo, Japan), four times daily for 3 months; the dosage was tapered thereafter. Topical tropicamide was not included in the postoperative regimen.

Shimizu T., Hayashi T., Ishida A., Kobayashi A., Yamaguchi T., Mizuki N., Yuda K, & Yamagami S. (2022). Evaluation of corneal nerves and dendritic cells by in vivo confocal microscopy after Descemet’s membrane keratoplasty for bullous keratopathy. Scientific Reports, 12, 6936.

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