B6 sjl tg villin cre 997gum j

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B6.SJL-Tg(Villin-cre)997Gum/J is a transgenic mouse strain that expresses Cre recombinase under the control of the villin promoter. The villin promoter drives Cre expression in the intestinal epithelium.

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B6 cg msh2tm2.1rak j, by Jackson ImmunoResearch (2 mentions)

Spelling variants of this product

B6.SJL (73 citations) Villin-Cre (50 citations) SJL/J (29 citations)

2 protocols using b6 sjl tg villin cre 997gum j

Conditional Msh2 Knockout Mice and Human Samples

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The mouse strains B6.SJL-Tg(Villin-cre)997Gum/J and B6.Cg-Msh2^tm2.1Rak/J were obtained from The Jackson Laboratory (Bar Harbor, USA). By crossing both, the conditional Msh2 allele has been placed under the control of the Villin-Cre transgene. Mice were genotyped as described [6 (link)]. VC^+/?Msh2^LoxP/LoxP (Msh2^−/−) and VC^−/−Msh2^LoxP/LoxP (Msh2^+/+) mice were bred under specific pathogen-free conditions. A mouse doublet consisted of one Msh2^−/− and one Msh2^+/+ mouse from one litter. In addition, we analyzed normal human colon samples of patient 7 (74 years old, female, MSH6 mutation carrier) of the cohort described in [3 (link)].

Herberg M., Siebert S., Quaas M., Thalheim T., Rother K., Hussong M., Altmüller J., Kerner C., Galle J., Schweiger M.R, & Aust G. (2019). Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine. Clinical Epigenetics, 11, 65.

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Conditional Msh2 Knockout Mouse Model

Cited 1 time

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The mouse strains B6.SJL-Tg(Villin-Cre)997Gum/J and B6.Cg-Msh2tm2.1Rak/J were obtained from The Jackson Laboratory (Bar Harbor, MA, USA). By crossing both, the conditional Msh2 allele was placed under the control of the Villin-Cre transgene. Mice were genotyped as described [15 (link)]. VC^+/?Msh2^LoxP/LoxP (Msh2^−/−) and VC^−/−Msh2^flox/flox (Msh2^+/+) mice were bred under specific pathogen-free conditions.

Thalheim T., Siebert S., Quaas M., Herberg M., Schweiger M.R., Aust G, & Galle J. (2021). Epigenetic Drifts during Long-Term Intestinal Organoid Culture. Cells, 10(7), 1718.

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