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7600 110 autoanalyzer

Manufactured by Hitachi
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Sourced in Japan

The Hitachi 7600-110 autoanalyzer is a laboratory instrument designed for automated chemical analysis. It is capable of performing a variety of clinical chemistry tests on samples. The device is equipped with multiple reagent dispensers, a sample handling system, and analytical modules to facilitate efficient and accurate analysis of various biological samples.

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Lab products found in correlation

Xt 1800i, by Sysmex (3 mentions) Gapdh, by Cell Signaling Technology (2 mentions) Potassium dichromate, by Sinopharm (1 mentions) Lead acetate, by Sinopharm (1 mentions) Cupric sulfate, by Sinopharm (1 mentions) Cadmium dichloride, by Sinopharm (1 mentions) Nickel dichloride, by Sinopharm (1 mentions) Manganese dichloride, by Sinopharm (1 mentions) Nf κb, by Cell Signaling Technology (1 mentions) Zinc sulfate heptahydrate, by Sinopharm (1 mentions) Inos assay kit, by Nanjing Jiancheng (1 mentions) Nexion 300d, by PerkinElmer (1 mentions) C jun, by Cell Signaling Technology (1 mentions) Bcl2 associated x (bax), by Cell Signaling Technology (1 mentions) Bcl 2, by Cell Signaling Technology (1 mentions) Cleaved caspase 3, by Cell Signaling Technology (1 mentions) Optima 2100 dv, by PerkinElmer (1 mentions)

Spelling variants of this product

Autoanalyzer (102 citations) Hitachi 7600 autoanalyzer (83 citations) 7600–110 chemistry autoanalyzer (2 citations)

8 protocols using 7600 110 autoanalyzer

1

Pharmacokinetics and Biodistribution of ZIF-8 Nanoparticles

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Mice were administered with ZIF-8 and ZIF-8-0.6 GPa at concentration of 25 mg/kg by intravenous (i.v.) injection. 1 ml blood was collected at various time points (0, 0.17, 0.5, 1, 2, 4, 8, 12, and 24 h) and analyzed by inductively coupled plasma-optical emission spectroscopy (ICP-OES). Mice were also i. v. administered with ZIF-8-0.6 GPa (50 mg/kg). Three mice of one group were randomly sacrificed at 1, 3, and 7 d. The major organs were collected, and the concentration of Zn was tested by ICP-OES.
Additionally, mice were i. v. administered with PBS, ZIF-8 (25 mg/kg), and ZIF-8-0.6 GPa (25 and 50 mg/kg). The blood of mice sacrificed at one day were collected and analyzed by Blood Analyzer (Sysmex XT-1800i, Japan), and Hitachi 7600-110 Autoanalyzer (Hitachi, Tokyo, Japan). TNF-α, IFN-γ, IL-6, and IL-12 were tested by enzyme-linked immunosorbent assay or ELISA (PBL Biomedical Laboratories and BDBiosciences) according to the manufacturer's instructions.
Jiang Z., Li Y., Wei Z., Yuan B., Wang Y., Akakuru O.U., Li Y., Li J, & Wu A. (2020). Pressure-induced amorphous zeolitic imidazole frameworks with reduced toxicity and increased tumor accumulation improves therapeutic efficacy In vivo. Bioactive Materials, 6(3), 740-748.
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2

Nanoparticle Toxicity Assessment in Sprague Dawley Rats

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Ni nanoparticles were obtained from Danyang City Alloy and Steel Refinery Co, Ltd (Danyang, Jiangsu, People’s Republic of China) (50 nm). Isoflurane was obtained from Sun Chemical Technology Co, Ltd (Shanghai, People’s Republic of China). A Hitachi 7600-110 autoanalyzer (Hitachi Ltd, Tokyo, Japan) and blood analyzer (Sysmex XT-1800i; Sysmex Co, Kobe, Japan) were used for biochemical and hematological analysis, respectively. Sprague Dawley rats were purchased from Zhejiang Provincial Laboratory Animal Science Center (Hangzhou, Zhejiang, People’s Repulic of China).
Magaye R.R., Yue X., Zou B., Shi H., Yu H., Liu K., Lin X., Xu J., Yang C., Wu A, & Zhao J. (2014). Acute toxicity of nickel nanoparticles in rats after intravenous injection. International Journal of Nanomedicine, 9, 1393-1402.
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3

Evaluating APT-Mn-ZIF-90 Toxicity in Mice

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To evaluate the toxicity of APT-Mn-ZIF-90 in vivo, four groups of Balb/c mice were used (n = 5), and all the mice were treated with APT-Mn-ZIF-90 (25, 50, or 100 mg kg−1) or PBS via a one-time intravenous injection. The survival rate and body weight were recorded for 30 days. To advance our understanding of the toxicity in vivo, another group of treated mice was killed on the 7th day. The collected blood was analyzed by a blood analyzer (Sysmex XT-1800i, Japan), and Hitachi 7600 − 110 autoanalyzer (Hitachi, Tokyo, Japan), and the major organs were collected and stained with Hematoxylin and Eosin (H&E). Furthermore, to investigate the metabolism of APT-Mn-ZIF-90 in healthy mice, each mouse was injected with 100 μL of APT-Mn-ZIF-90 (50 mg kg−1) and was killed on days 1, 7, and 14. The main organs were removed, and their Mn concentrations were tested with ICP-OES.
Jiang Z., Yuan B., Qiu N., Wang Y., Sun L., Wei Z., Li Y., Zheng J., Jin Y., Li Y., Du S., Li J, & Wu A. (2019). Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy. Nano-Micro Letters, 11, 61.
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4

Investigating Heavy Metal Toxicity in Rats

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Heavy metal compounds, lead acetate ((CH3COO)2Pb·3H2O, AR ≥ 99.5%), cadmium dichloride (CdCl2·2.5H2O, AR ≥ 99.0%), nickel dichloride (NiCl2·6H2O, AR ≥ 98.0%), manganese dichloride (MnCl2·4H2O, AR ≥ 99.0%), zinc sulfate heptahydrate (ZnSO4·7H2O, AR ≥ 99.5%), cupric sulfate (CuSO4·5H2O, AR ≥ 99.0%), and potassium dichromate (K2Cr2O7, AR ≥ 99.8%) were purchased from Sinopharm Chemical Reagent Co., Ltd (Shanghai, China). Methyl mercury chloride was purchased from Ehrenstorfer GmbH (affiliation, Germany). The biochemical and hematological analysis were performed by Hitachi 7600-110 autoanalyzer (Hitachi Ltd, Tokyo, Japan) and blood analyzer (Sysmex XT-1800i; Sysmex Co, Kobe, Japan), respectively. Water maze testing was performed using a MWM video analysis system (RD1101-MWM-G, Shanghai Mobiledatum Information Technology Co., Ltd., China). The monoclonal antibodies including p38, P-p38, JNK, p-JNK (phosphorylated JNK), NFκB, Nrf2, Akt, and GAPDH were obtained from Cell Signaling Technology (Danfoss, MA, USA). Sprague Dawley (SD) rats were obtained from Zhejiang Provincial Laboratory Animal Science Center (Hangzhou, Zhejiang, China).
Su H., Li Z., Fiati Kenston S.S., Shi H., Wang Y., Song X., Gu Y., Barber T., Aldinger J., Zou B., Ding M., Zhao J, & Lin X. (2017). Joint Toxicity of Different Heavy Metal Mixtures after a Short-Term Oral Repeated-Administration in Rats. International Journal of Environmental Research and Public Health, 14(10), 1164.
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5

Biochemical Analysis of Mouse Serum

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The blood was collected from the eyeballs of mice. The serum was separated by centrifugation and used for studying various biochemical parameters. The blood was analyzed by blood analyzer (Sysmes XT-1800i, Sysmex Corporation, Kobe, Japan) and Hitachi 7600-110 autoanalyzer (Hitachi). The blood routine parameters mainly include red blood cell (RBC), white blood cell (WBC), hemoglobin (HGB) and blood platelet (PLT). The serum biochemistry test includes lactate dehydrogenase (LDH), alanine transaminase (ALT), total protein (TP), albumin (ALB), globulin (GLB), total protein (TP), aspartate transaminase (AST) and so on.
Chen Y., Fei X., Ye C., Qian Q., Ye Z., Xie S., Chen J., Zhu M., Ran N., Hou M., Xu L, & Yu Z. (2019). Acute hepatotoxicity of multimodal targeted imaging contrast agent NaLuF4:Gd,Yb,Er-PEG/PEI-FA in mice. The Journal of toxicological sciences, 44(9).
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6

Myocardial Infarction in Mice

Cited 1 time
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C57BL/6 male mice were purchased from an experimental animal company. XTL continuous zoom stereomicroscope (Shenzhen Ruiwode Life Technology Company, Shenzhen, China) and MicroVent 1 small animal ventilator (Pittsfield, USA) were used in the microsurgical operations. Hitachi 7600-110 autoanalyzer was used for biochemical analyses. Chloral hydrate and isoflurane were obtained from Sun Chemical Technology (Shanghai, China). In addition, microsurgical instruments, endotracheal intubations, and disposable intravenous catheters (22 G) were used in this study. The iNOS assay kit was obtained from Nanjing Jiancheng Bioengineering Institute (Nanjing, China).
Thirty C57BL/6 male mice were randomly divided into three groups (n=10 mice/group): a sham-operation group (sham), an AMI operation group (AMI), and a nitrite pretreatment+AMI operation group (N+AMI). Before the AMI operation, mice in the N+AMI group were pretreated with sodium nitrite in drinking water (50 mg/L in double distilled water) for 7 days according to previous studies (11 (link),12 (link)). Mice were housed in controlled temperature, humidity, and 12-h light–dark cycle with free access to chow and water. Mice studies were approved by the Ningbo University Institutional Animal Care and Use Committee.
Wang Y., Song X., Yue X., Su H., Gu Y., Bowman L., Ding M., Zou B., Zhao J, & Lin X. (2017). Protection by nitrite against the ischemic effects induced by acute myocardial infarction in mice. Anatolian Journal of Cardiology, 18(5), 315-320.
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7

Comprehensive Patient Data Analysis

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We obtained information on patient demographics and initial laboratory values, including hematocrit, albumin, serum creatinine, total cholesterol, C-reactive protein (CRP), LOS, and follow-up duration. Creatinine concentrations were determined by the Jaffe reaction with a Hitachi 7600-110 autoanalyzer (Tokyo, Japan). Also, the Charlson comorbidity index (CCI) score was used to compare comorbidity status at the time of admission [23 (link)].
Yoo J., Lee J.S., Lee J., Jeon J.S., Noh H., Han D.C, & Kwon S.H. (2015). Relationship between duration of hospital-acquired acute kidney injury and mortality: a prospective observational study. The Korean Journal of Internal Medicine, 30(2), 205-211.
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8

Biochemical and Hematological Analysis of Fe3O4-TiO2 NPs

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Biochemical and hematological analyses were performed with a 7600-110 autoanalyzer (Hitachi Ltd., Tokyo, Japan) and blood analyzer (XT-1800i; Sysmex Corporation, Kobe, Japan), respectively. Metal content (Ti and Fe) was detected by inductively coupled plasma (ICP) mass spectrometry (MS; Nexion 300D; PerkinElmer Inc., Waltham, MA, USA) and ICP optical emission spectroscopy (Optima 2100DV; PerkinElmer Inc.). The monoclonal antibodies p38, phosphorylated p38 (p-p38), JNK, phosphorylated JNK (p-JNK), ERK, HO1, c-Jun, cleaved caspase 3, Bcl2, Bax, p50, p53, Nrf2, Akt, and GAPDH were obtained from Cell Signaling Technology (Danvers, MA, USA). Sprague Dawley rats were obtained from Zhejiang Provincial Laboratory Animal Science Center (Hangzhou, China). Fe3O4-TiO2 NPs and TiO2 NPs were obtained from our cooperation team at the Chinese Academy of Materials (Ningbo, China).
Su H., Song X., Li J., Iqbal M.Z., Kenston S.S., Li Z., Wu A., Ding M, & Zhao J. (2018). Biosafety evaluation of Janus Fe3O4-TiO2 nanoparticles in Sprague Dawley rats after intravenous injection. International Journal of Nanomedicine, 13, 6987-7001.
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