The patients were told to empty the stomach and hold the urine. They were in the supine position and kept smooth breathing, foot first was selected, and the parameters of Toshiba 64-slice CT scanner (NMPA (I) 20063300657) were set as follows: tube voltage of 120 kV, tube current of 310 mA, noise index of 8.63, speed of 0.6 s/circle, slice thickness of 5 mm, pitch of 0.984, and FOV of 36 cm × 36 cm. Low-concentration iso-osmotic non-ionic contrast medium, iodixanol (manufacturer: Jiangsu Hengrui Medicine Co. Ltd.; NMPA approval no. H20103675), was administered via intravenous injection through the right median cubital vein by a single-tube pressure syringe, with a total dose of 65 ml and a rate of 3.5 ml/s. After injection, enhanced scans in the cortical phase, myeloid phase, and secretory phase were performed, and the CT values were measured by the workstation.
Iodixanol
Manufactured by Jiangsu Hengrui Medicine
Sourced in China
Iodixanol is a non-ionic, iso-osmolar, water-soluble contrast agent used in various laboratory and clinical applications. It is a synthetic compound that contains iodine, which provides the contrast properties. Iodixanol is commonly used in medical imaging procedures, such as computed tomography (CT) scans and magnetic resonance imaging (MRI), to enhance the visibility of internal structures and improve diagnostic accuracy. The specific details and intended uses of Iodixanol should be obtained from the manufacturer or relevant scientific literature.
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Lab products found in correlation
4 protocols using iodixanol
1
CT Angiography of Renal Vasculature
2
TACE for VX2 Liver Tumor Model
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TACE was performed after the successful implantation of the VX2 liver tumor. Concisely, the right femoral artery was exposed by an incision under anesthesia and was later punctured using an 18-G puncture needle. It was then catheterized with a 5-F vascular sheath (Terumo, Tokyo, Japan), as depicted in Figure 1c, followed by the retrograde insertion of a 2.7-F microcatheter (Terumo, Tokyo, Japan) into the common hepatic artery under monitoring by X-ray fluoroscopy. The iodixanol, a contrast agent (Jiangsu Hengrui Medicine Co., Ltd., Jiangsu, China), was injected manually (3 ml) at a speed of 0.5 ml/s. The location and staining of the VX2 liver cancer were confirmed using a digital subtraction angiography machine (Artis zee ceiling-mounted system, Siemens, Erlangen, Germany). The infusion was then hand-injected into the VX2 carcinoma-feeding artery as per the group-specific protocol. Finally, we removed the catheter, ligated the right femoral artery, and sutured the wounds. Rabbits were later aroused and allowed to recover, returned to their cages, and followed up daily until they were sacrificed.
3
Epirubicin-Loaded Microsphere Preparation
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Before the initiation of DEB-TACE, the concentrated solution of epirubicin was prepared with 4 ml of sterile water for injection and 80 mg of epirubicin hydrochloride, and the concentration was 20 mg/ml. Then the CSM (diameter 100-300μm) were loaded with epirubicin as follows: firstly, the CSM and sterile water were extracted by a 20 mL syringe and inverted placed for 5 min until the CSM were totally precipitated, then pushed out the supernatant liquor. Subsequently, the concentrated solution of epirubicin was mixed with the CSM using a tee joint and then stored by a syringe, and the syringe containing the mixture of CSM and epirubicin solution was placed at room temperature and shaken gently every 5 min until almost all epirubicin were loaded (loading time more than 30 min). After that, the nonionic contrast medium (iodixanol [320 mg I/mL], Jiangsu Hengrui Medicine, Jiangsu, China) was added into the mixture as a 1:1 ratio and the mixture were kept still for 5 min for further application.
4
DSA Cerebral Angiography Procedure
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The Siemens Artis angiographic system were used for the DSA examination. After femoral artery access, the DSA cerebral angiography was performed for observing the bypass blood flow and cerebral perfusion. After the distal end of a 4F contrast catheter was placed 4 cm below the carotid artery bifurcation, cerebral angiography was performed with the contrast agent of iodixanol (100 ml/piece, Jiangsu Hengrui medicine, China), contrast agent flow rate of 5 ml/s, total injection dose of 10 ml, injection delay of 1 s, high-pressure syringe pressure of 300 PSI, and frame number of 4 fp/s until the venous sinus phase.
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