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Anti mouse il 12 il 23 p40

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The Anti-mouse IL-12/IL-23 p40 is a laboratory reagent used for research purposes. It is a monoclonal antibody that binds to the p40 subunit shared by the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) in mice. This product can be used to detect, quantify, or neutralize the target proteins in various in vitro and in vivo experimental settings.

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Spelling variants of this product

Anti-IL-12 (7 citations) IL-12 (5 citations) Anti-mouse IL-12 (3 citations) Anti-mouse IL-12 p40 (2 citations)

3 protocols using anti mouse il 12 il 23 p40

1

Neutralization of IL-17 and IL-12/23 in Mice

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For IL-17 neutralization, mice were i.p. injected with Anti-mouse IL-17 antibody (Clone: 17F3) or isotype control IgG1 (Clone: MOPC-21) (10 µg/g mouse weight) every other day for 2 weeks. For IL-12/IL-23 p40 neutralization, mice were i.p. injected with anti-mouse IL-12/IL-23 p40 antibody (Clone: C17.8) or isotype control IgG2a (Clone: 2A3) (100 µg per mice) every other day for 2 weeks. Anti-mouse IL-17 (Clone: 17F3), anti-mouse IL-12/IL-23 p40 (Clone: C17.8), mouse IgG1 isotype control (Clone: MOPC-21), and mouse IgG2a isotype control (Clone: 2A3) were bought from BioXcell company.
Jie Z., Yang J.Y., Gu M., Wang H., Xie X., Li Y., Liu T., Zhu L., Shi J., Zhang L., Zhou X., Joo D., Brightbill H.D., Cong Y., Lin D., Cheng X, & Sun S.C. (2018). NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nature immunology, 19(11), 1224-1235.
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2

Neutralization of IL-17 and IL-12/23 in Mice

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For IL-17 neutralization, mice were i.p. injected with Anti-mouse IL-17 antibody (Clone: 17F3) or isotype control IgG1 (Clone: MOPC-21) (10 µg/g mouse weight) every other day for 2 weeks. For IL-12/IL-23 p40 neutralization, mice were i.p. injected with anti-mouse IL-12/IL-23 p40 antibody (Clone: C17.8) or isotype control IgG2a (Clone: 2A3) (100 µg per mice) every other day for 2 weeks. Anti-mouse IL-17 (Clone: 17F3), anti-mouse IL-12/IL-23 p40 (Clone: C17.8), mouse IgG1 isotype control (Clone: MOPC-21), and mouse IgG2a isotype control (Clone: 2A3) were bought from BioXcell company.
Jie Z., Yang J.Y., Gu M., Wang H., Xie X., Li Y., Liu T., Zhu L., Shi J., Zhang L., Zhou X., Joo D., Brightbill H.D., Cong Y., Lin D., Cheng X, & Sun S.C. (2018). NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nature immunology, 19(11), 1224-1235.
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3

Experimental Psoriasis Induction and Modulation

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To induce experimental psoriasis, IMQ (Imiquimod Cream 5%, supplied with cream on sterile applicator pads, Perrigo. Co.) was applied daily to mice on the right ear or both ears, applying ~5 mg per ear daily for 7–21 days. To deplete mouse CD4+ T cells, or to neutralize IL17 or IL12/IL23p40 cytokines, 250 μg of anti-mouse CD4 mAb (Bioxcell), anti-mouse IL17mAb (Bioxcell), anti-mouse IL12/IL23p40 (Bioxcell), or rat IgG2a isotype control (Bioxcell) was injected i.p. 2 days before IMQ treatment and injected every 4 days during the treatment period. To inhibit the lysyl amine oxidase enzyme activity, either vehicle (PBS) or 300mg/kg BAPN was injected i.p. every other day during the IMQ treatment period.
Huang L.H., Zinselmeyer B.H., Chang C.H., Saunders B.T., Elvington A.F., Baba O., Broekelmann T.J., Qi L., Rueve J.S., Swartz M.A., Kim B.S., Mecham R.P., Wiig H., Thomas M.J., Sorci-Thomas M.G, & Randolph G.J. (2018). Interleukin 17 drives interstitial entrapment of tissue lipoproteins in experimental psoriasis. Cell metabolism, 29(2), 475-487.e7.
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