The precursor DPA-SPIAD and the standard compound [19F]FDPA were purchased from Shenzhen PET-BiO Technology Co., Ltd. (China). Tetrabutylammonium methanesulfonate (TBAOMs), anhydrous CH3CN, and 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195) were purchased from Sigma-Aldrich (Germany). O-18 enriched water (purity ≥ 98%) was purchased from Jiangsu Huayi Technology Co., Ltd (China). Other chemicals and reagents were purchased from commercial supplies, without further purification.
1 2 chlorophenyl n methyl n 1 methylpropyl 3 isoquinolinecarboxamide pk11195
Manufactured by Merck Group
Sourced in Germany, United States
1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195) is a synthetic compound used as a research tool in various scientific applications. It functions as a selective ligand for the peripheral benzodiazepine receptor (PBR), also known as the translocator protein (TSPO). This compound is commonly utilized in studies related to neurological disorders, inflammation, and other areas of scientific investigation that involve the TSPO.
Automatically generated - may contain errors
2 protocols using 1 2 chlorophenyl n methyl n 1 methylpropyl 3 isoquinolinecarboxamide pk11195
1
Radiolabeled Fluorine-19 Compound Synthesis
2
Activation of Glial Cells in Neuroinflammation
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1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195) and 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one (Ro5-4864; 4'-chlorodiazepam) were purchased from Sigma-Aldrich (St. Louis, MO, USA). N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide (XBD-173; Empapunil; AC5216), N, N-dihexyl-2-(4-fluorophenyl) indole-3-acetamide (FGIN-1-27) and 6-chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride (Etifoxine) were purchased from Tocris Biosciences (Avonmouth, Bristol, United Kingdom). The stock solutions of PK11195 (50 mM) and Ro5-4864 (25 mM) were prepared in absolute ethanol, and those of XBD-173 (100 mM), FGIN-1-27 (100 mM) and Etifoxine (100 mM) in dimethyl sulfoxide. Pam3CSK4 (tripalmitoylated lipopeptide), HKLM (heat-killed preparation of Listeria monocytogenes), Poly (I:C) HMW (double-stranded RNA high molecular weight), Poly (I:C) LMW (double-stranded RNA low molecular weight), ST-FLA (flagellin from Salmonela typhimurium), FSL-1(Pam2CGDPKHPKSF), ssRNA (single strand RNA, 20 mer), ODN1826 (oligonucleotides containing unmethylated CpG dinucleotides) were purchased from Invivogen (San Diego, CA, USA). LPS was obtained from Sigma-Aldrich. Anti-Iba1 was purchased from Wako (Osaka, Japan). Anti-GFAP was obtained from Neuromics (Edina, MN, USA).
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