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Erlortinib

Manufactured by Selleck Chemicals
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Sourced in United States

Erlortinib is a lab equipment product used for chemical synthesis and analysis. It is a round-bottomed flask designed for a variety of laboratory applications.

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Lab products found in correlation

Rapamycin, by Selleck Chemicals (2 mentions) Gefitinib, by Selleck Chemicals (2 mentions) Hcc827 cells, by American Type Culture Collection (2 mentions) Osimertinib, by Selleck Chemicals (2 mentions) Pf 4708671, by Selleck Chemicals (2 mentions) Nutlin 3a, by Selleck Chemicals (2 mentions) Sp 141, by Cayman Chemical (2 mentions) Pc 9 cell line, by National Collection of Authenticated Cell Cultures (2 mentions)

2 protocols using erlortinib

1

Characterization of EGFR-Targeted Drug Resistance in Lung Cancer Cells

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PC-9 cell line was obtained from the Type Culture Collection of the Chinese Academy of Sciences, Shanghai, China). PC-9/G cells (Gefitinib resistant) were provided kindly by the Department of Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai (21 (link)). HCC827 cells were obtained from ATCC (Manassas, VA, USA). All cell lines were authenticated by STR assay and showed no mycoplasma contamination confirmed by PCR-based assay. Gefitinib, erlortinib, osimertinib, PF-4708671, nutlin-3a and rapamycin were purchased from Selleck Chemicals (Houston, TX, USA). SP-141 was purchased from Cayman Chemical (Ann Arbor, MI, USA). AKT (#4691), p-S6 (#4858), p-AKT (#4060 CST), and S6K1 (#2708) antibodies were from Cell Signaling Technology. IGF-IR (sc463), p-IGF-IR (sc81499), TFEB (sc166736) antibodies were from Santa Cruz Biotech. p-TFEB antibody was obtained from Millpore Sigma (ABE1971). MDM2 antibodies were obtained from both Abcam (Ab243657) for IP and IHC application and from Cell Signaling Technology for Western-blots (#86934). Antibodies used for IHC or IF including p-S6K1 (AF3228), p-S6 (AF7331), p-4EBP1 (AF2308) and mTOR (AF6308) were purchased from Afinity Biosciences.
Shen H., Wang G.C., Li X., Ge X., Wang M., Shi Z.M., Bhardwaj V., Wang Z.X., Zinner R.G., Peiper S.C., Aplin A.E., Jiang B.H, & He J. (2020). S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer. Oncogene, 39(49), 7181-7195.
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2

Characterization of EGFR-Targeted Drug Resistance in Lung Cancer Cells

Check if the same lab product or an alternative is used in the 5 most similar protocols
PC-9 cell line was obtained from the Type Culture Collection of the Chinese Academy of Sciences, Shanghai, China). PC-9/G cells (Gefitinib resistant) were provided kindly by the Department of Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai (21 (link)). HCC827 cells were obtained from ATCC (Manassas, VA, USA). All cell lines were authenticated by STR assay and showed no mycoplasma contamination confirmed by PCR-based assay. Gefitinib, erlortinib, osimertinib, PF-4708671, nutlin-3a and rapamycin were purchased from Selleck Chemicals (Houston, TX, USA). SP-141 was purchased from Cayman Chemical (Ann Arbor, MI, USA). AKT (#4691), p-S6 (#4858), p-AKT (#4060 CST), and S6K1 (#2708) antibodies were from Cell Signaling Technology. IGF-IR (sc463), p-IGF-IR (sc81499), TFEB (sc166736) antibodies were from Santa Cruz Biotech. p-TFEB antibody was obtained from Millpore Sigma (ABE1971). MDM2 antibodies were obtained from both Abcam (Ab243657) for IP and IHC application and from Cell Signaling Technology for Western-blots (#86934). Antibodies used for IHC or IF including p-S6K1 (AF3228), p-S6 (AF7331), p-4EBP1 (AF2308) and mTOR (AF6308) were purchased from Afinity Biosciences.
Shen H., Wang G.C., Li X., Ge X., Wang M., Shi Z.M., Bhardwaj V., Wang Z.X., Zinner R.G., Peiper S.C., Aplin A.E., Jiang B.H, & He J. (2020). S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer. Oncogene, 39(49), 7181-7195.
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