A375 cell line

Manufactured by European Collection of Authenticated Cell Cultures

The A375 cell line is a well-established and commonly used human melanoma cell line. It was derived from a skin sample of a 54-year-old female patient with malignant melanoma. The A375 cell line is characterized by its rapid growth and ability to form tumors in immunodeficient mice.

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Lab products found in correlation

Cremophor rh40, by Merck Group (2 mentions) Trametinib, by MedChemExpress (2 mentions) Peg400, by Merck Group (2 mentions) Labrafil m 1944 cs, by Gattefosse (2 mentions) A375 cell line, by American Type Culture Collection (2 mentions) Siremadlin, by MedChemExpress (1 mentions) Realtime glo mt cell viability assay kit, by Promega (1 mentions) Celltiter 96 aqueous non radioactive cell proliferation assay mts, by Promega (1 mentions)

2 protocols using a375 cell line

Siremadlin and Trametinib Combination in Melanoma

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Siremadlin (catalogue number HY-18658) and trametinib (catalogue number HY-10999) used in this study were obtained from MedChemExpress. PEG 400 (catalogue number 81172) and Cremophor RH40 (catalogue number 07076) were provided by Merck (formerly Sigma-Aldrich), EtOH (catalogue number 1016/12/19) was provided by POCH, and Labrafil M1944CS (catalogue number 178290) was provided by Gattefosse. The A375 cell line used in the single drug administration in vivo studies was obtained from American Type Culture Collection (CRL-1619). For drug combination in vivo studies, the A375 cell line was provided by European Collection of Authenticated Cell Cultures (88113005).

Witkowski J., Polak S., Rogulski Z, & Pawelec D. (2022). In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part II. International Journal of Molecular Sciences, 23(19), 11939.

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Evaluation of HDM201 and Trametinib Combination

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HDM201 (catalog number HY-18658) and Trametinib (catalog number HY-10999) used in this study were obtained from MedChemExpress. RealTime-Glo™ MT Cell Viability Assay kit and CellTiter 96^® AQueous Non-Radioactive Cell Proliferation Assay (MTS) were provided by Promega. The A375 cell line used in the in vitro studies was obtained from American Type Culture Collection (CRL-1619). PEG 400 (catalog number 81172) and Cremophor RH40 (catalog number 07076) were provided by Merck (formerly Sigma-Aldrich), EtOH (catalog number 1016/12/19) was provided by POCH, and Labrafil M1944CS (catalog number 178290) was provided by Gattefosse. For drug combination in vivo studies, A375 cell line was provided by European Collection of Authenticated Cell Cultures (88113005).

Witkowski J., Polak S., Rogulski Z, & Pawelec D. (2022). In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part I. International Journal of Molecular Sciences, 23(21), 12984.

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