Lonafarnib

Manufactured by Cayman Chemical

Lonafarnib is a chemical compound used in research applications. It functions as a farnesyltransferase inhibitor, which is a class of enzymes involved in the posttranslational modification of certain proteins. Lonafarnib is commonly utilized in scientific studies, but its specific intended uses are not provided.

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Lab products found in correlation

2 protocols using lonafarnib

Molecular Profiling of Cancer Targets

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Sunitinib (#13159) and lonafarnib (#11746) were obtained from Cayman Chemical Company (Ann Arbor, MI). Anti-FNTB (#ab109625) antibody was obtained from Abcam (Cambridge, UK). Anti-β-actin (#3700), SETD2 (23486) and anti-PBRM1 (91894) antibodies were obtained from Cell Signaling Technology, (Danvers, MA). Anti-BAP1(sc-28383) antibody was obtained from Santa Cruz (Dallas, TX).

Makhov P., Sohn J.A., Serebriiskii I.G., Fazliyeva R., Khazak V., Boumber Y., Uzzo R.G, & Kolenko V.M. (2020). CRISPR/Cas9 genome-wide loss-of-function screening identifies druggable cellular factors involved in sunitinib resistance in renal cell carcinoma. British Journal of Cancer, 123(12), 1749-1756.

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Antibody Panel for Cell Signaling Analysis

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Rabbit polyclonal antibodies to GFP, phosphorylated ERK1/2, phosphorylated RB, ERK1/2, cyclin D1, phosphorylated FADD at Ser¹⁹⁴, AURKA, phosphorylated β-Catenin, β-Catenin, phosphorylated MDM2, and PLK1 were purchased from Cell Signaling Technology. The antibody for human FADD was obtained from BD Biosciences. Antibodies against cyclin B1, CK1α, MDM2 and p53 were purchased from Santa Cruz Biotechnology. The antibody against mouse FADD used for western blotting was initially purchased from Epitomics (cat# 3523-1), and then from Abcam (cat# ab124812). Antibodies for BUB1, β-Actin, mouse FADD (cat# ab24533) and GFP were from Abcam. Ki-67 antibody was obtained from Vector Labs. CKI-7 was from Sigma. PD0325901 was purchased from Selleck, and Lonafarnib was bought from Cayman Chemical. Alamar Blue was purchased from Invitrogen. Luciferin was obtained from Promega. Adenovirus-Cre was bought from the University of Michigan Vector core.

Bowman B.M., Sebolt K.A., Hoff B.A., Boes J.L., Daniels D.L., Heist K.A., Galbán C.J., Patel R.M., Zhang J., Beer D.G., Ross B.D., Rehemtulla A, & Galbán S. (2015). Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer. Science signaling, 8(361), ra9.

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