Alendronic acid

Manufactured by Tokyo Chemical Industry

Alendronic acid is a chemical compound used as a laboratory reagent. It is a white crystalline powder that is soluble in water and ethanol. Alendronic acid is primarily used as a building block in organic synthesis and as a standard reference material in analytical chemistry.

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2 protocols using alendronic acid

Polymer-Based Nanoparticle Synthesis for Cancer Research

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Poly(D,L-lactide-co-glycolide) carboxylate end group (50:50, 0.55–0.75 dL/g) was purchased from DURECT Corporation (Birmingham, AL, USA). 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt) (16:0 Succinyl PE) and L-α-Phosphatidylethanolamine-N-(lissamine rhodamine B sulfonyl) (Ammonium Salt) (Egg-Transphosphatidylated, Chicken) (Egg Liss Rhod PE) were purchased from Avanti Polar Lipid Inc. (Alabaster, AL, USA). Alendronic acid was purchased from TCI America. 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) were purchased from Sigma-Aldrich (Milwaukee, WI, USA). Doxorubicin hydrochloride salt was purchased from LC Laboratories (Woburn, MA, USA). Osteosarcoma Cell line K7M2 and Mouse Melanoma (B16-F10) were purchased from ATCC and maintained according to the manufacturer’s recommendation. All other chemicals and solvents were purchased from Sigma-Aldrich (Milwaukee, WI, USA) and used as received.

Nguyen T.D., Pitchaimani A, & Aryal S. (2016). Engineered Nanomedicine with Alendronic Acid Corona Improves Targeting to Osteosarcoma. Scientific Reports, 6, 36707.

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Characterization of Functionalized Nanoparticles

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Zoledronic acid (zoledronate or Zol) monohydrate, alendronic acid (alendronate or Ale) and disodium clodronic acid (clodronate or Clo) tetrahydrate were from TCI America (Portland, OR). Alexa Fluor 647 (AF647)-labeled Zol was from BioVinc LLC (Los Angeles, CA). Sodium hydrate, calcium chloride, zinc chloride, sodium dihydrogen phosphate, sodium hydrogen phosphate, uranyl acetate (UA) dihydrate, formic acid, formalin, collagenase IV, paraformaldehyde, polyoxymethylene, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), polyoxyethylene (5) nonylphenylether (NP-5) and polyoxyethylene (10) octylphenyl ether (OEP-10) were from Sigma-Aldrich (St. Louis, MO). DOPA monosodium salt and 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)-2000] (DSPE-PEG_2K) were from Avanti Polar Lipid, Inc. (Alabaster, AL). Cyclohexane, dimethyl sulfoxide, hexanol, chloroform and ethanol were from Thermo Fisher Scientific Co. (Pittsburgh, PA). APC-labeled anti-mouse CD206 (MMR) antibody was from BioLegend Co. (San Diego, CA). All reagents were used without further purification.

Li X., Naguib Y.W., Valdes S., Hufnagel S, & Cui Z. (2017). Reverse Microemulsion-Based Synthesis of (Bis)phosphonate-Metal Materials with Controllable Physical Properties: An Example Using Zoledronic Acid-Calcium Complexes. ACS applied materials & interfaces, 9(16), 14478-14489.

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