Methyl acrylate (MA, Sigma-Aldrich, 99%) was purified before use by a neutral aluminum oxide column to remove the inhibitor and was kept at 0 °C. Ru(Cp*)Cl(PPh3)2 (Sigma-Aldrich), tetralin (Sigma-Aldrich, 99%), and ethyl 2-bromopropionate (EBP, Sigma-Aldrich, purity >98%) were used as received and kept at 0 °C. Al(acac)3 (Sigma-Aldrich, purity >97%), ethanol (Sigma-Aldrich, anhydrous, ≥99.5%), iso-propanol (Sigma-Aldrich, anhydrous, ≥99.5%), octanol (Sigma-Aldrich, ACS reagent, ≥99%), and benzyl alcohol (Sigma-Aldrich, anhydrous, 99.8%) were degassed before use. Toluene (Sigma-Aldrich; ≥99.9%) was purified by being passed through purification columns (JCM, JCM-3SPS-SA-6) and bubbled with dry nitrogen gas for more than 15 min immediately before use. Molecular sieves 4 Å (MS 4 Å) were dried under reduced pressure at 300 °C by a heat gun before use.
Methyl acrylate ma
Manufactured by Merck Group
Sourced in United States
Methyl acrylate (MA) is a colorless, flammable liquid with a pungent odor. It is a versatile chemical compound used as a building block in various industrial and laboratory applications. MA serves as a monomer for the production of acrylic polymers and copolymers, which have a wide range of uses. This product's core function is to act as a precursor material for the synthesis of other chemical substances, without further interpretation on its intended use.
Automatically generated - may contain errors
Lab products found in correlation
Toluene, by Merck Group (2 mentions)
Tetralin, by Merck Group (1 mentions)
Octanol, by Merck Group (1 mentions)
Benzyl alcohol, by Merck Group (1 mentions)
Ethanol, by Merck Group (1 mentions)
Isopropanol, by Merck Group (1 mentions)
Poly ethylene glycol methyl ether mpeg, by Merck Group (1 mentions)
Diethyl ether, by Merck Group (1 mentions)
Ethylenediamine eda, by Merck Group (1 mentions)
2 carboxyethyl acrylate cea, by Merck Group (1 mentions)
Sodium chloride (nacl), by Carl Roth (1 mentions)
Acryloyl chloride, by Thermo Fisher Scientific (1 mentions)
Cyanomethyl dodecyl trithiocarbonate, by Merck Group (1 mentions)
Sodium bicarbonate, by Thermo Fisher Scientific (1 mentions)
Cdcl3, by Cambridge Isotopes (1 mentions)
Trioxane, by Merck Group (1 mentions)
Acetic acid, by Cambridge Isotopes (1 mentions)
Isobornyl acrylate iba, by Merck Group (1 mentions)
Acetic anhydride, by Merck Group (1 mentions)
Sodium sulfate, by Merck Group (1 mentions)
6 protocols using methyl acrylate ma
1
Synthesis of Methyl Acrylate Monomers
2
Synthesis of mPEG-Carboplatin Conjugate
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Ethylenediamine (EDA, Mw 60.10 Da) and toluene were purchased from Merck (Darmstadt, Germany). Methyl acrylate (MA, Mw 86.09 Da), poly (ethylene glycol) methyl ether (mPEG, Mw: 5 kDa), 4-Nitrophenyl chloroformate (NPC, Mw 201.56 Da), tetrahydrofuran (THF), and diethyl ether were purchased from Sigma-Aldrich (St. Louis, MO, USA). Methanol was supplied by Fisher Scientific (Waltham, MA, USA). Carboplatin (CAR) was received from TCI (Tokyo, Japan). Spectra/Por® Dialysis Membrane (MWCO 3.5 kDa and 12–14 kDa) was purchased from Spectrum Laboratories, Inc. (Rancho Dominguez, CA, USA). All reagents and solvents were used as received without further purification.
3
Synthesis of Polymer Nanocomposites using RAFT Agent
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2-(Dodecylthiocarbonothioylthio)propionic acid (CTA, Sigma Aldrich, St. Louis, Missouri, USA) was used without further purification. Azobis(isobutyronitril) (AIBN, ≥99%, Fluka, St. Louis, MI, USA) was recrystallized from methanol and stored at −18 °C. Methyl acrylate (MA, Sigma Aldrich, St. Louis, MI, USA) and 2-carboxyethyl acrylate (CEA, Sigma Aldrich, St. Louis, MI, USA) were purified by passing through a column of basic alumina (Sigma Aldrich, St. Louis, MI, USA) to remove the inhibitor. Sodium MMT was purchased from Alfa Aesar, Kandel, Germany. Propylen glycol monomethyl ether acetate (PGMEA, p.a., J&K Scientific, Beijing, China) was used as received. The used three-arm star shaped RAFT agent S3 was synthesized following a literature known procedure [16 (link)].
4
Synthesis and Purification of Polymeric Reagents
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Azobisisobutyronitrile
(AIBN, Sigma-Aldrich) was recrystallized from methanol prior to use.
Isobornyl acrylate (IBA; technical, Sigma-Aldrich) and lauryl acrylate
(LA; >98%, TCI) were passed over a basic alumina column prior to
use
to remove the stabilizer. Methyl acrylate (MA; 99%, Sigma-Aldrich)
was distilled prior to use. Pyridine, dichloromethane (DCM), and triethylamine
were distilled over calcium hydride (CaH2) prior to use.
Cyanomethyl dodecyl trithiocarbonate (CDT) was synthesized according
to a procedure mentioned in the literature.44 (link) 2-(Dodecylthiocarbonothioylthio)-2-methylpropionic acid (DDMAT;
98%, Sigma-Aldrich), trioxane (≥99%, Sigma-Aldrich), biphenyl
(>99%, Sigma-Aldrich), acetophenone (AP; 99%, Sigma-Aldrich), sodium
sulfate (≥99%, Sigma-Aldrich), acetic anhydride (≥99%,
Sigma-Aldrich), trans-2-[3-(4-tert-butylphenyl)-2-methyl-2-propenylidene]-malononitrile (DCTB; Sigma-Aldrich,
>98%), potassium trifluoroacetate (KTFA; Sigma-Aldrich, 98%), acryloyl
chloride (96%, Alfa Aesar), furfuryl alcohol (≥98%, Fischer
Scientific), hydrogen chloride (HCl; 37% solution in H2O, Acros Organics), sodium bicarbonate (>99%, Acros organics),
sodium
chloride (≥99.8%, Roth), tert-butyl methylether
(TBME; 99.9%), acetic acid (AcOH; 99.7%), and CDCl3 (99.8%,
Cambridge Isotope Laboratories) were used as received. All other solvents
were obtained from Biosolve and were used as received.
(AIBN, Sigma-Aldrich) was recrystallized from methanol prior to use.
Isobornyl acrylate (IBA; technical, Sigma-Aldrich) and lauryl acrylate
(LA; >98%, TCI) were passed over a basic alumina column prior to
use
to remove the stabilizer. Methyl acrylate (MA; 99%, Sigma-Aldrich)
was distilled prior to use. Pyridine, dichloromethane (DCM), and triethylamine
were distilled over calcium hydride (CaH2) prior to use.
Cyanomethyl dodecyl trithiocarbonate (CDT) was synthesized according
to a procedure mentioned in the literature.44 (link) 2-(Dodecylthiocarbonothioylthio)-2-methylpropionic acid (DDMAT;
98%, Sigma-Aldrich), trioxane (≥99%, Sigma-Aldrich), biphenyl
(>99%, Sigma-Aldrich), acetophenone (AP; 99%, Sigma-Aldrich), sodium
sulfate (≥99%, Sigma-Aldrich), acetic anhydride (≥99%,
Sigma-Aldrich), trans-2-[3-(4-tert-butylphenyl)-2-methyl-2-propenylidene]-malononitrile (DCTB; Sigma-Aldrich,
>98%), potassium trifluoroacetate (KTFA; Sigma-Aldrich, 98%), acryloyl
chloride (96%, Alfa Aesar), furfuryl alcohol (≥98%, Fischer
Scientific), hydrogen chloride (HCl; 37% solution in H2O, Acros Organics), sodium bicarbonate (>99%, Acros organics),
sodium
chloride (≥99.8%, Roth), tert-butyl methylether
(TBME; 99.9%), acetic acid (AcOH; 99.7%), and CDCl3 (99.8%,
Cambridge Isotope Laboratories) were used as received. All other solvents
were obtained from Biosolve and were used as received.
5
Synthesis of Polymer Brushes via ATRP
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Tert-butyl acrylate (tBuA, 99%, Alfa Aesar, Warsaw, Poland), methyl acrylate (MA, 99%, Sigma-Aldrich, Poznań, Poland), and anisole (Alfa Aesar, 99%) were dried over molecular sieves and stored under nitrogen. Copper(I) bromide (CuBr, 98%, Fluka, Steinheim, Germany) was purified by stirring in glacial acetic acid followed by filtration and washing with ethanol and diethyl ether, respectively. Next, the solid was dried under vacuum. Potassium chloride (KCl, VWR Chemicals, Gdansk, Poland) and N,N,N′,N″,N″-pentamethyldiethylenetriamine (PMDETA, 99%, Sigma-Aldrich, Poznan, Poland) were used as received. Pentaerythritoltetrakis(2-bromoisobutyrate) (PTLBr) was obtained according to a procedure described previously [35 (link)].
6
Synthesis and Characterization of Acrylate Copolymer Films
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Copolymers sheets (ca. 0.4 mm of thickness) were obtained by radical polymerisation of a solution of ethyl acrylate (EA), methyl acrylate, MA, (Sigma-Aldrich, Steinheim, Germany) and merging ratios of EA/MA of 70/30, 50/50 and 30/70 wt.% using 1 % wt benzoin (98% pure, Scharlau) as photoinitiator. The reaction was carried out in ultraviolet light for 24 h. After polymerisation, low molecular weight substances were extracted from the material by drying in vacuum to constant weight. Besides, pure poly(ethyl acrylate), PEA, and poly(methyl acrylate), PMA, sheets were prepared in the same way. Thereafter, materials with the afore-mentioned composition will be named as PEA100, PEA70, PEA50, PEA30 and PMA100.
Thin films were prepared using a spin-coater (Brewer Science). Each one of the synthesised polymers and copolymers was dissolved in toluene at concentration between 4 and 6 wt%.
Spin casting was performed on 12 and 25 mm glass coverslips at 3000 rpm for 30 s. Samples were dried in vacuum at 60 °C before further characterization. The obtained films are not porous and have approximately 500 nm of thickness.
Thin films were prepared using a spin-coater (Brewer Science). Each one of the synthesised polymers and copolymers was dissolved in toluene at concentration between 4 and 6 wt%.
Spin casting was performed on 12 and 25 mm glass coverslips at 3000 rpm for 30 s. Samples were dried in vacuum at 60 °C before further characterization. The obtained films are not porous and have approximately 500 nm of thickness.
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