Irgacure 2959

Manufactured by BASF

Sourced in Germany, United States, China

Irgacure 2959 is a photoinitiator used in the production of various lab equipment. It is a crystalline solid that absorbs ultraviolet light, initiating a chemical reaction that leads to the formation of free radicals. These free radicals then facilitate the curing or polymerization of certain materials when exposed to UV light.

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Lab products found in correlation

Cl 1000 crosslinker, by Analytik Jena (6 mentions) Methacrylic anhydride, by Merck Group (5 mentions) Gelatin type a, by Merck Group (3 mentions) Hpk 125, by Philips (2 mentions) Chloramphenicol, by Merck Group (2 mentions) Molecular grade agar, by Thermo Fisher Scientific (2 mentions) Ampicillin, by Merck Group (2 mentions) Cefazolin, by Merck Group (2 mentions) Anhydrous magnesium sulfate, by Thermo Fisher Scientific (2 mentions) Dimethyl sulfoxide (dmso), by Thermo Fisher Scientific (2 mentions) 8 arm peg acrylate, by Creative PEGWorks (1 mentions) Millicell ez slide, by Merck Group (1 mentions) Avidin fitc, by Merck Group (1 mentions) Hydrochloric acid (hcl), by Thermo Fisher Scientific (1 mentions) 1 ethyl 3 3 dimethylaminopropyl carbodiimide hydrochloride edc, by Merck Group (1 mentions) 2 mercaptoethanol, by Merck Group (1 mentions) Cl 1000l uv crosslinker, by Analytik Jena (1 mentions) Luria bertani broth lb, by Merck Group (1 mentions) Tryptic soy broth tsb, by Merck Group (1 mentions) Ammonium persulfate, by Maclin Biochemical Technology (1 mentions)

Close spelling variants of this product

2-hydroxy-1-[4-(hydroxyethoxy) phenyl]-2-methyl-1propanone (Irgacure 2959) (5 citations) Irgacure 2959 photoinitiator (3 citations) 4-(2-Hydroxyethoxy) phenyl-(2-hydroxy-2-propyl) ketone (Irgacure 2959) (3 citations)

63 protocols using irgacure 2959

Gelation of Modified Polysaccharide

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Example 1

Gelation with Sample 1A

2 g of sample 1A were dissolved in 98 g of distilled water to obtain a 2 wt % aqueous solution of the modified polysaccharide. 1 ml of a 34 mM aqueous solution of the photoinitiator (Irgacure 2959, from BASF) were added to 30 g of the 2% solution of sample 1A and stirred for 10 minutes. The obtained solution was irradiated with UV light, using an Helios Italquarz Polymer 400 W lamp, for 90 seconds to obtain gelation. (GEL 1A-1)

Gelation was also obtained at room temperature mixing 30 g of the 2% solution of sample 1A with 10 g of a 9% aqueous solution of poly(ethylene glycol) diacrylate (PEGDA, Mw 700), 0.9 g of a sodium metabisulfite 1 wt % solution, 0.5 g of a 2 wt % solution of sodium persulfate and 0.4 g of an iron sulphate(II) 1 wt % solution (GEL 1A-2).

US10202535B2. Method for treating subterranean formations (2019-02-12). LAMBERTI SPA [IT]. Inventors: Enrico Cavo [IT], Lorenzo Giardini [IT], Angelo Casiraghi [IT], Luigi Merli [IT], Mauro Tenconi [IT], Pierangelo Pirovano [IT], Giovanni Floridi [IT], Giuseppe Li Bassi [IT], Roberto Macchi [IT].

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Laccase Immobilization via Photopolymerization

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The immobilisation of laccase (Trametes versicolor, EC 1.10.3.2) was carried out in accordance with our previous work [22 (link)]. Briefly, 534 mg (7.51 mmol) of Acrylamide and 466 mg (0.62 mmol) of Polyethylene Glycol Dimethacrylate750 were added to a laccase solution (25 mg in 3.0 mL sodium citrate buffer, 10⁻³ mol L⁻¹, pH 5.0). Then, 2.4 (w/w) % 1-[4-(2-hydroxyethoxy)-phenyl]-2-hydroxy-2-methyl-1-propane-1-one (Irgacure 2959, maximum absorption at around 275 nm) was added as a photo-initiator and the mixture was placed in a reaction cell consisting of two 10 × 10 cm² glass plates brought together using binder clips and separated with Teflon spacers (thickness 1.6 mm). The solution was allowed to react for 10 min under a high-pressure mercury lamp (HPK 125, Philips, Amsterdam, Netherlands, 10 mW cm⁻², 275 nm wavelength 275). After removing unreacted species via washing with distilled water, the resulting hydrogel was dried overnight in an oven under vacuum at 40 °C.
Irgacure 2959 was purchased from BASF, Ludwigshafen, Germany, and all other chemicals were from Merck KGaA, Darmstadt, Germany.

Cirillo G., Curcio M., Oliviero Rossi C., De Filpo G., Baratta M., De Luca M., Iemma F, & Nicoletta F.P. (2023). Curcumin–Sodium Alginate and Curcumin–Chitosan Conjugates as Drug Delivery Systems: An Interesting Rheological Behaviour. Molecules, 28(15), 5893.

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Synthesis of PEG-Laminin Hydrogels

Cited 2 times

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PEG-LM hydrogels were synthesized as previously described in refs. 52 (link) and 53 (link). Briefly, full-length LM111 (Trevigen, Gaithersburg, MD, USA) was conjugated with acrylate-PEG-hydroxysuccinimide (10 kDa; Creative PEGWorks, Chapel Hill, NC, USA) to produce a PEGylated-LM solution. PEG-LM was dialyzed against PBS to remove any unreacted acrylate-PEG-hydroxysuccinimide, and the final LM concentration in the resulting PEG-LM conjugate precursor solution was determined via absorbance reading at 280 nm. Hydrogels were synthesized by combining 500 μg/ml PEG-LM precursor solution with varying amounts of 8-arm PEG acrylate (20 kDa; Creative PEGWorks) in chamber slides (Millicell EZ Slide; MilliporeSigma, Burlington, MA, USA) and polymerized in the presence of a photoinitiator (0.1% w/v; Irgacure 2959; BASF, Ludwigshafen, Germany) upon UV exposure (3–4 mW × cm⁻²). Hydrogels were produced at either 4% (w/v; soft 0.3 kPa) or 20% (stiff, 20 kPa; Fig. 1C, D).

Fearing B.V., Jing L., Barcellona M.N., Witte S.E., Buchowski J.M., Zebala L.P., Kelly M.P., Luhmann S., Gupta M.C., Pathak A, & Setton L.A. (2019). Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape. The FASEB Journal, 33(12), 14022-14035.

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Hydrogel Photopolymerization and DNA Functionalization

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Hydrogels were photopolymerized by solubilizing 35 mg (0.98 M) AA in 480 µL of the CCA. To this mixture, a solution of 1 mg (0.015 M) BA and 24 mg (0.42 M) AGE in 20 µL DMSO was added. The photoinitiator Irgacure 2959 (BASF; Florham Park, NJ) (10 wt% in DMSO) was added at a final concentration of 0.05 wt% to the CCA-monomer solution. The solution was then pipetted into a mold formed by two glass slides separated by a 273 ± 2 µm Parafilm spacer. Samples were flood exposed with 365 nm light at 15 mW/cm² from a UV mercury lamp for 45 min. Films were subsequently equilibrated and stored in ultrapure water for a minimum of 24 h prior to DNA functionalization.

MacConaghy K.I., Chadly D.M., Stoykovich M.P, & Kaar J.L. (2015). Label-free Detection of Missense Mutations and Methylation Differences in the p53 Gene Using Optically Diffracting Hydrogels. The Analyst, 140(18), 6354-6362.

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Biomaterial Functionalization via PEG-dAAm

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PEG-dAAm
3.7 kDa, 1-ethyl-3-(3-dimethyl-aminopropyl)
carbodiimide hydrochloride (EDC), 2-mercaptoethanol, 2-(N-morpholino)ethanesulfonic acid (MES), phenylalanine ammonia lyase
(PAL), glucose oxidase (GOx), avidin-FITC, IgG-FITC, and bovine serum
albumin (BSA)-FITC were purchased from Sigma-Aldrich. Sodium carbonate
(NaCO₃), calcium chloride (CaCl₂), N-hydroxysuccinimide (NHS), sodium bicarbonate (NaHCO₃),
and hydrochloric acid (HCl) were purchased from Fisher Scientific.
Irgacure 2959 was purchased from BASF. Acrylate-PEG-NH-Boc MW 2 kDa
and PEG-dAAm (0.6, 2, 10, and 20 kDa) were purchased from Creative
PEGWorks. Cy5-NHS was synthesized as previously reported.^{18 (link)}

Delbreil P., Banquy X, & Brambilla D. (2023). Template-Based Porous Hydrogel Microparticles as Carriers for Therapeutic Proteins. ACS Bio & Med Chem Au, 3(3), 252-260.

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Gelatin Methacryloyl Hydrogel for 3D Cell Culture

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Gelatin methacryloyl (gelMA) was synthesized according to a previously published protocol, as used as a platform to produce hydrogels for 3D tissue culture (Melchels et al., 2014 (link)). Briefly, gelatin type A (obtained from porcine skin; Sigma-Aldrich) in PBS was functionalized with methacrylic anhydride groups to achieve an 80% degree of functionalization of the available primary amines. Subsequently, a 10% w/v solution of gelMA was supplemented with 0.1% w/v 2-hydroxy-1-[4-(2-hydroxyethoxy)phenyl]-2-methyl-1-propanone (Irgacure 2959; BASF, Ludwigshafen, Germany) as a photoinitiator. AuCPCs of each donor were expanded to passage 4 and were encapsulated in the hydrogel at a density of 1.5 × 10⁷ cells/mL at 37°C. The cell-laden gel was cast into a custom-made Teflon™ mold and subsequently subjected to UV-radiation for 15 minutes (wavelength λ = 365 nm, intensity E = 7 mW/cm², at height of 12 cm; CL-1000L UV Crosslinker, UVP, UK) to allow free-radical polymerization crosslinking of the hydrogel, producing cylindrical samples (diameter = 6 mm, height = 2 mm). As controls, cell-free hydrogel samples were prepared under the same conditions. All samples were cultured in chondrogenic differentiation medium for 1, 28 and 56 days at 37°C and 5% CO² and receiving fresh media 3 times per week.

Otto I.A., Bernal P.N., Rikkers M., van Rijen M.H., Mensinga A., Kon M., Breugem C.C., Levato R, & Malda J. (2022). Human adult, pediatric and microtia auricular cartilage harbor fibronectin-adhering progenitor cells with regenerative ear reconstruction potential. iScience, 25(9), 104979.

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Tuning PEG Hydrogel Friction Properties

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To tailor the frictional properties of poly(ethylene glycol) diacrylate-based hydrogels (PEG, average M_n = 700 g/mol), various concentrations of negatively charged 4-styrene sulfonic acid (SSA) (both Sigma-Aldrich) were added to the PEG precursor solution and covalently incorporated into the PEG network during photo-polymerization. In order to retain alike total molarities and comparable polymer network densities in all PEG-based hydrogels, the uncharged compound methyl methacrylate (MMA) was added to hydrogels with a lower SSA content (PEG-40S) (Table 1). Just like SSA, MMA allows photocrosslinking via its vinyl group, resulting in comparable crosslinking densities.
Briefly, 2 % w/v ALMA or PEG/SSA with or without MMA were dissolved in phosphate-buffered saline (PBS) containing 0.2 % w/v Irgacure 2959 (1-(4-(2-hydroxyethoxy)-phenyl)-2-hydroxy-2-methyl-1-propane-1-one, BASF, Ludwigshafen, Germany) and sterile filtered using a 0.2 µm syringe filter. Hydrogels were photocrosslinked between two parallel glass slides separated with a 300 µm spacer by exposure to 365 nm light at an intensity of ~ 2.5 mW/cm² in a CL-1000 crosslinker (UVP, Upland, CA, USA) for 30 minutes. The glass slides were separated after solidification, leaving a thin hydrogel layer behind on one of the slides. Hydrogels were washed briefly in sterile PBS to remove unreacted compounds.

Meinert C., Schrobback K., Levett P.A., Lutton C., Sah R.L, & Klein T.J. (2016). Tailoring hydrogel surface properties to modulate cellular response to shear loading. Acta biomaterialia, 52, 105-117.

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Photocurable Ropinirole HCl Ink Formulation

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Inks were prepared with 0.50 wt % Irgacure 2959 photoinitator (BASF), 30 w t%, 2.00 wt % ropinirole HCl (Sequoia Research Products, >98%) and poly(ethylene glycol) diacrylate (PEGDA) (M= 700g mol -1 , Sigma Aldrich), Irgacure 2959 was stirred into the PEGDA at elevated temperature (110 °C, 600 rpm) until dissolved. Water and the drug were then stirred into the solution (40 °C, 600 rpm) until dissolved. The ink was then degassed with nitrogen for 10 minutes and filtered the solution through a 0.45 mm pore size hydrophilic 13mm diameter Millex PTFE filter (Sigma Aldrich) prior to cartridge loading. To block ambient light, which can prematurely cure the resin during ink formulation and printing, the ink vessel and cartridge were wrapped several times in silver duct tape. To minimize solvent loss during heating and degassing stages, the solution was sealed with a rubber septa cap. Base ink (i.e. API free) formulations, were prepared for control purposes and formulated with 2 wt % additional PEGDA in order to keep the water content constant. All materials were used as received.

Clark E.A., Alexander M.R., Irvine D.J., Roberts C.J., Wallace M.J., Sharpe S., Yoo J., Hague R.J.M., Tuck C.J, & Wildman R.D. (2017). 3D printing of tablets using inkjet with UV photoinitiation. International journal of pharmaceutics, 529(1-2).

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Hydrogel Scaffold for Antibiotic Delivery

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All compounds were used as received. Poly(ethylene glycol) dimethacrylate, (PEGDMA, M_n = 750 Da), 3-(trimethoxysilyl)propyl methacrylate, ampicillin (BioReagent grade), chloramphenicol (BioReagent grade), M9 minimal salts (M9 media), D-(+)-glucose, calcium chloride (anhydrous), phosphate buffered saline (PBS, 1× sterile biograde), tryptic soy broth (TSB), and Luria-Bertani broth (LB) were purchased from Sigma-Aldrich (St. Louis, MO). Irgacure 2959 was obtained from BASF (Ludwigshafen, Germany). Magnesium sulfate anhydrous and molecular grade agar were obtained from Fisher Scientific (Fair Lawn, NJ). Deionized (DI) water was obtained from a Barnstead Nanopure Infinity water purification system (Thermo Fisher Scientific, Waltham, WA).

Kolewe K.W., Peyton S.R, & Schiffman J.D. (2015). Fewer Bacteria Adhere to Softer Hydrogels. ACS applied materials & interfaces, 7(35), 19562-19569.

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Synthesis and Characterization of PEI-Coated Silica Hydrogels

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Acrylamide (AM) was purchased from Tokyo Chemical Industry (TCI, Shanghai, China). N, N-methylenebis(acrylamide) (BAM, purity 99%) and branched polyethylenimine (PEI aqueous solution, 50 w/w%, Mw~70,000), PEI (Mw 800, 1600, purity 99%) used during measurement were purchased from Aladdin Inc. (Shanghai, China) and Sigma-Aldrich (Shanghai, China). Hydrophobic silicon dioxide particles (SiO₂ HPs, diameter ~20 nm, KH570 silane-treated) were purchased from Fuhong Materials Inc. (Shanxi, China). Muscovite mica sheets used for SFA measurement were obtained from S&J Trading (USA). Fe₃O₄ nano-particles (purity 99.5%) were purchased from Macklin Inc. (Shanghai, China). The conductivity of deionized water in this study is 0.05 μS/cm. All reagents in this work were used as received without further purification. For thermal initiation, ammonium persulfate (Macklin, Shanghai, China) was utilized to replace the photoinitiator, Irgacure 2959 (BASF, Shanghai, China). The weight composition of the materials is 8.5 g AM, 3.5 g PEI@SiO₂, BAM 0.051 g, and 0.17 g ammonium persulfate and 55 g of water, and the weight ratio of HPs:PEI =0:1, 0.5:1 and 1:1, respectively.

Huang J., Wang Y., Liu P., Li J., Song M., Cui J., Wei L., Yan Y, & Liu J. (2023). Kneading-Dough-Inspired Quickly Dispersing of Hydrophobic Particles into Aqueous Solutions for Designing Functional Hydrogels. Gels, 9(3), 242.

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