Hydroxypropyl methylcellulose hpmc

TCR was kindly supplied by Adwia Pharmaceuticals Co. (Cairo, Egypt). Sorbitan monoesters (Span 60) were obtained from Loba Chemie (Mumbai, India). Polysorbates (Tween^® 80) were obtained from BDH (Kingston, England). Hydroxypropyl methylcellulose (HPMC) were obtained from Colorcon, UK. Propylene glycol (PG) was purchased from Winlab (Germini-house, England). Oleic acid (OA) was obtained from Lobachemi (Mumbai, India). Chloroform, ethanol, and acetonitrile (HPLC grade) were purchased from Fisher Scientific Co. (Hampton, NH, USA). All other ingredients were of pure analytical grade.

Crystalline CUR (>98%) and crystalline MAG (>98%) were acquired from Aladdin Biochemical Technology Co., Ltd. (Shanghai, China) and Tianben Biological Engineering Co., Ltd. (Xi’an, China), respectively. Hydroxypropyl methyl cellulose (HPMC), hydroxypropyl cellulose (HPC), polyvinyl pyrrolidone (PVP) K30, microcrystalline cellulose (MCC), kollidon VA64 (VA64), and plasdone S630 (S630) were purchased from Colorcon Co., Ltd. (Philadelphia, PA, USA). The chemical structures of CUR, MAG, HPMC, HPC, and PVP K30 are given in Figure 1. Tween-80 and phosphoric acid were supplied from Nanjing Chemical Reagent Co., Ltd. (Nanjing, China). Methanol and acetonitrile of chromatographic grade were purchased by Anpel Scientific Instrument Co., Ltd. (Shanghai, China). Deionized water was prepared by an ultrapure water purification system (OLABO, Boke Instruments, Jinan, China).

Ketoconazole (99.8% purity) was from Shanghai Aladdin Reagent Co., Ltd. (Shanghai, China). Hydroxypropyl methylcellulose (HPMC) was generously provided by Colorcon Ltd. (Dartford, UK). Polyvinylpyrrolidone-vinyl acetate copolymer (PVPVA) was kindly gifted by BASF Ltd. (Ludwigshafen, Germany). Fasted Simulated Intestinal Fluid (FaSSIF) powder was from biorelevant.com Ltd. (London, UK). Chromatographic pure acetonitrile, methanol, phosphoric acid, and potassium dihydrogen phosphate were from Sigma-Aldrich Co., Ltd. (Saint Louis, MO, USA). Other reagents were purchased from Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China) unless otherwise stated.