Tim trio 3.0 t mri scanner

On the same day of the aEEG recording, infants underwent a non-sedated, non-contrast brain MRI following our institutional neonatal MRI guidelines.^{17 (link)} T1 and T2 images were obtained using Siemens TIM Trio 3.0 T MRI scanner (Siemens Medical Solutions, Erlangen, Germany).
An MRI scoring tool adapted from Kidokoro et al.^{18 (link)} was used, which combines quantitative and qualitative measurements of brain abnormalities in preterm infants at TEA. The quantitative scoring included: dilated lateral ventricles dimensions (score 0 to 3), biparietal diameter (corrected to the GA, scored 0 to 3), interhemispheric distance (score 0 to 3), deep gray matter volume (corrected to the GA, scored 0 to 3), and cerebellar volume (corrected to the GA and scored 0 to 3). Qualitative scoring included: white matter cystic lesions, white matter focal signal abnormality, myelination delay, cortical gray matter signal abnormality, gyral maturation, deep gray matter signal abnormality, and cerebellar signal abnormality. The variables were scored by an experienced reader (AMM) blinded to the clinical information of the patients and the corresponding aEEG measures. The abnormality scoring system was divided into four grades: normal (0 to 3), mild (4 to 7), moderate (8 to 11), and severe (> 12), for the preterm brain at TEA.

Subjects in the NKI-RS sample underwent a scan session using a Siemens TIM Trio 3.0 T MRI scanner with a 12 channel head coil. Resting-state fMRI scans were collected using an echo-planar imaging (EPI) sequence with the following parameters: time repetition (TR) / time echo (TE) = 2500 / 30 ms, flip angle (FA) = 80°, field of view (FOV) = 216 × 216 mm², voxel size = 3.0 × 3.0 × 3.0 mm², distance factor = 10%, number of slices = 38. Each scan session was 650 s long and comprised 260 functional volumes. Participants were instructed to keep their eyes closed, relax their minds, and not to move.

We have reported similar procedures for data acquisition and analysis previously (Masterson et al. 2016 (link)). All MRI data acquisition was completed at the MRI Facility using a Siemens TIM-Trio 3.0T MRI scanner (Siemens Trio, Erlangen, Germany). Scans were identical for both sessions. The following parameters were used to obtain a T1-weighted MPRAGE structural scan for each subject: TE = 2.26 ms; T = 1900 ms; flip angle = 9°; matrix size = 256 × 215 mm; field of view = 250 × 218 mm; 176 slices; slice thickness = 1 mm; voxel size = 0.977 × 0.977 × 1 mm; 1 total acquisition. T2*-weighted echo-planar images were obtained using the following parameters: TE = 28 ms; TR = 1800 ms; flip angle = 90°; matrix size = 64 × 64; field of view = 220 × 220 mm; 36 slices; slice thickness = 3 mm; voxel size = 3.4 × 3.4 × 3 mm; 270 total acquisitions.