All animal experiments were approved by the Ethics Committee of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine. UCHL1 flox/flox mice and LysM-Cre mice were obtained from Gempharmatech Co., Ltd. In all our experiments, The same sex litters of UCHL1 /flox were used as control.
Lysm cre mice
Manufactured by GemPharmatech
Sourced in China
LysM-Cre mice are a strain of transgenic mice that express Cre recombinase under the control of the lysozyme M (LysM) promoter. LysM is a gene that is primarily expressed in myeloid cells, including monocytes, macrophages, and granulocytes. The Cre recombinase enzyme allows for the conditional deletion or modification of target genes in these cell types.
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Lab products found in correlation
3 protocols using lysm cre mice
1
UCHL1 Deletion in LysM+ Cells
2
Genetically Modified Mouse Models
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Brd9-flox mice (Strain NO. T008489), LysM-Cre mice (Strain NO. T003822), and WT C57BL/6J mice (Strain NO. N000013) from GemPharmatech (Nanjing, China) and tdTomato (Strain NO. 007909) mouse line62 (link) from Jackson Laboratory (Maine, USA) were used and cross-bred in this study. All mice were used for analysis regardless of sex. All mice were housed in pathogen-free conditions with constant ambient temperature (22 ± 2 °C) and humidity (55 ± 10%), with an alternating 12-h light/dark cycle. All mice were euthanized by carbon dioxide overdose followed by cervical dislocation. All animal studies were approved by the Institutional Animal Care and Use Committee at Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University (SH9H-2022-A926-1).
3
Genetically Modified Mice for Macrophage-Specific Tim-3 KO
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Both experimental and breeding mice were housed in a pathogen-free animal facility. All animal experiments were subjected to approval by the Animal Ethics Committee of Nanchang University (CDYFY-IACUC-202301QR046). C57BL/6 Tim-3fl/fl and Lys M-Cre mice were procured from Gempharmatech Co. Ltd. (Nanjing, China). Tim-3 fl/fl mice were crossed with Lys M-Cre mice to obtain macrophage cell-specific Tim-3-knockout mice (LysMCre Tim-3 fl/fl; Tim-3M−KO).
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