B6.129p2 lyz2tm1 cre lfo j lysm cre mice

Manufactured by Jackson ImmunoResearch

The B6.129P2-Lyz2tm1(cre)lfo/J (LysM-Cre) mice express Cre recombinase under the control of the lysozyme 2 (Lyz2) gene promoter, which is active in myeloid cells, including macrophages and neutrophils. This mouse strain can be used to induce conditional gene targeting or deletion in these cell types.

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Lab products found in correlation

C57bl 6j control mice, by Jackson ImmunoResearch (1 mentions)

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LysM-Cre (106 citations) LysM-Cre mice (105 citations) LysM-Cre (B6.129p2-Lyz2tm1(cre)lfo/J) (2 citations) B6.129P2-Lyz2tm1(cre) (2 citations)

2 protocols using b6.129p2 lyz2tm1 cre lfo j lysm cre mice

Genetic Murine Myeloid Cell Isolation

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All mouse work was performed in accordance with Fred Hutchinson Cancer Center, IACUC and AAALAS guidelines. B6.129P2-Lyz2^tm1(cre)lfo/J (LysM-Cre) mice and C57Bl/6J control mice were purchased from Jackson Laboratory (004781 and 000644).

Roh-Johnson M., Shah A.N., Stonick J.A., Poudel K.R., Kargl J., Yang G.H., di Martino J., Hernandez R.E., Gast C.E., Zarour L.R., Antoku S., Houghton A.M., Bravo-Cordero J.J., Wong M.H., Condeelis J, & Moens C.B. (2017). Macrophage-dependent cytoplasmic transfer during melanoma invasion in vivo. Developmental cell, 43(5), 549-562.e6.

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Wnt4 Conditional Knockout in LysMCre Mice

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B6.129P2-Lyz2^tm1(cre)lfo/J (LysMCre) mice were purchased from The Jackson Laboratory. Mice with a Wnt4 conditional allele have been described elsewhere (85 (link)) and were originally a kind gift from S. Vainio (Oulu University, Finland). Mice were bred and housed under specific pathogen-free conditions in sterile ventilated racks at the animal facility of INRS-Centre Armand-Frappier Santé Biotechnologie. All procedures were approved by the Comité institutionnel de la protection des animaux of the INRS and were conducted in accordance with the Canadian Council on Animal Care guidelines. Only female mice were used for the following experiments.

Tlili M., Acevedo H., Descoteaux A., Germain M, & Heinonen K.M. (2022). Cell-intrinsic Wnt4 ligand regulates mitochondrial oxidative phosphorylation in macrophages. The Journal of Biological Chemistry, 298(8), 102193.

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