Iomeron 300 mg ml

CTP studies were performed at admission, 24 h, 7 days and 3 months post stroke. Prior to CTP scan, a NECT scan was performed to locate hypodense ischemic lesion. Each CTP scan started with an intravenous injection of 50 mL of iodinated contrast agent (Iomeron 300 mg/ml, Bracco Imaging SpA, Milan, Italy) at the rate of 4 mL/s, followed by 45 mL of saline flush at the same infusion rate. A 20-gauge catheter and cephalic vein were used in peripheral venous access for contrast injection. Each CTP acquisition used a two-phase protocol: eight 5 mm-thick slices covering a 40 mm section of the brain were scanned continuously for 45 s with images reconstructed at 0.5 s intervals and then scanned once every 15 s for another 105 s for a total acquisition time of 2.5 min. The scan parameters for both phases were 25 cm FOV, 80 kV, 100 mA, and 1 s per gantry rotation. BBB permeability-surface (BBB-PS), cerebral blood flow (CBF) and cerebral blood volume (CBV) maps were generated with the delay insensitive CT Perfusion software based on the modified Johnson-Wilson model (GE Healthcare, Waukesha, WI) [18 (link), 19 (link)].

All imaging was conducted on a 64-slice Lightspeed VCT scanner (GE Healthcare, Waukesha, WI, USA). NCCT helical scans were performed from the skull base to the vertex using the following imaging parameters: 120 kV, 340 mA, 4x5-mm collimation, 1 second/rotation, and table speed of 15 mm/rotation. CTA was performed as follows: 0.7 mL/kg contrast (maximum 90 mL), 5- to 10-second delay from injection to scanning, 120 kV, 270 mA, 1 second/rotation, 1.25-mm thick slices, and table speed 3.75 mm/rotation. CTA covered from the carotid bifurcation to vertex. CTP studies were performed at admission with a dynamic first-pass bolus-tracking methodology according to a one-phase imaging protocol consisting of an acquisition of 50-seconds continuous (cine) scans reconstructed with a 25 cm field-of-view at 0.5 second intervals to produce a series of 99 sequential images for each of eight 5 mm thick sections (792 images; matrix size = 512 × 512) which covered a total of 4 cm from the basal ganglia to the lateral ventricles. The other parameters of the cine scan were 80 kV, 100 mA and 0.5 rotation time. The cine scan was initiated 5 seconds after the automatic injection (Medrad, Indianola, PA) of 40 ml of non-ionic contrast agent (Iomeron 300 mg/ml, Bracco Imaging SpA) at the rate of 4 ml/sec into an antecubital vein.