All DECT images were acquired using a 64-channel multi-detector CT scanner (Discovery CT750HD; GE Healthcare, Waukesha, WI). Scan parameters are listed in Table 1 . Following non-CE data acquisition, patients were administrated contrast material containing 350 mg/mL iodine (Iomeron 350; Eisai, Tokyo, Japan). The amount and injection duration of the contrast material and scan timing are presented in Table 1 . The MMD algorithm is a commercially unavailable postprocessing software (Liver Fat Quantification; GE Healthcare). Liver fat quantification algorithm was developed by using the MMD algorithm with fat, liver tissue, and blood in the material basis.[9 (link)] In the contrast-enhanced DECT data, a virtual unenhancement image was firstly applied before running liver fat quantification algorithm. In this step, the iodine contrast material has been removed and replaced by the same volume blood. The final output is the fat volume fraction (FVF) map.
Iomeron 350
Manufactured by Eisai
Sourced in Japan
Iomeron 350 is an iodinated contrast medium used for diagnostic imaging procedures. It contains iodine as the active ingredient and is formulated as an injectable solution.
Automatically generated - may contain errors
Lab products found in correlation
Somatom definition flash, by Siemens (2 mentions)
Discovery ct750 hd, by GE Healthcare (1 mentions)
Automatic bolus tracking program, by Canon (1 mentions)
Aquilion one prism, by Canon (1 mentions)
Omnipaque 300, by Daiichi Sankyo (1 mentions)
Iomeprol, by Eisai (1 mentions)
Nitropen, by Nippon Kayaku (1 mentions)
Aidr 3d, by Canon (1 mentions)
Aquilion one genesis edition, by Canon (1 mentions)
Somatom perspective, by Siemens (1 mentions)
Somatom definition as, by Siemens (1 mentions)
Omnipaque 350 injection, by Daiichi Sankyo (1 mentions)
6 protocols using iomeron 350
1
Quantifying Liver Fat with Dual-Energy CT
2
Low-Radiation Abdominal CT Imaging Protocol
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All scans were performed using a 320 row multidetector CT scanner (Aquilion ONE PRISM; Canon Medical Systems, Otawara, Japan) with the following parameters: 80 row × 0.5 mm, pitch of 0.813, 0.6 s rotation time (fixed), 120 kVp tube voltage, and automatic exposure control with a noise index of 20. The standard care of abdominal CT in our hospital is the MBIR protocol (FIRST BODY Mild), which is designed for low exposure, with a mean volume CT dose index (CTDIvol) of 7.9 mGy. This value was obtained by retrospectively evaluating the doses of 125 consecutive patients prior to the start of this study. Iohexol (Omnipaque 300; Daiichi-Sankyo, Tokyo, Japan), iomeprol (Iomeron 350; Eisai, Tokyo, Japan), or iopamidol (Iopamiron 370; Nihon Schering, Osaka, Japan) was administered via an antecubital vein using a 20-gauge catheter at a dose of 600 mgI/kg; the injection procedure was standard across all patients. The scan delays for arterial and portal venous phase imaging were determined using an automatic bolus-tracking program (Canon Medical Systems). The region of interest (ROI) cursor was placed in the aorta at the level of the diaphragmatic dome, and scanning for the arterial and portal venous phases began automatically at 20 and 60 s, respectively, after the trigger threshold of 100 Hounsfield Units was reached.
3
128-DETECTOR ROW CT IMAGING PROTOCOL
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All CTs were performed using a 128-detector row computed tomography (CT) system (SOMATOM Definition Flash; Siemens; Erlangen, Germany). The following imaging parameters were applied: tube voltage, 120 kVp; tube current, 160 mAs; beam pitch, 0.6; resolution 0.68 × 0.68 × 5 mm. Contrast agent (iomeprol, Iomeron 350; Eisai, Tokyo, Japan; 100 mL) was administered from the superficial vein of the upper extremity using double-head power injector (injection rate, 4.5 mL/sec). The contrast agent was followed by normal saline (30 mL) at the same injection rate. Imaging slices from the skull base to the lower were acquired 40 s after contrast agent injection.
4
Comprehensive 3D CT Angiography Protocol
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Patients underwent three-dimensional (3D) CT angiography using a 96- or 128- or 320-detector CT scanner. The tube potential was 120 kVp, and the tube current was adjusted by automatic exposure control with a noise index of 10 and a slice thickness of 0.5 mm. Iomeprol (350 mg I/ml, iomeron 350; Eisai, Tokyo, Japan) was used as contrast agent. Patients were injected with 0.6 g/kg iodine (upper limit, 47.25g) for 30 s at a rate of 2.6–4.5 ml/s. The bolus tracking method was initiated when the contrast in the thoracic aorta (diaphragm level) reached 150 Hounsfield units. Sixty seconds after the injection of iomeprol, the venous phase image was acquired. One hundred twenty seconds after the injection of contrast agent, the equilibrium phase image was acquired. An image processing analysis was performed using a 3D volume rendering technique with the Advantage Workstation system version 4.5 (GE Health care, Tokyo, Japan).
5
Optimized Coronary CTA Protocol
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A 320-row CT was used to perform coronary CT angiography (Aquilion ONE Genesis Edition; Canon Medical Systems Corporation). Oral β-blocker (metoprolol, 20 or 40 mg) was used 1 h before the exam to achieve the target heart rate of 65 beats per minute. A maximum dose of 12.5 mg of landiolol (Corebeta; Ono Parmaceutical) was given intravenously if the heart rate was > 65 bpm at the CT room [18 ]. All patients received 0.6 mg of sublingual nitroglycerin (Nitropen; Nippon Kayaku) before imaging. Patients received 18.0 mg iodine/kg/s of iomeprol (Iomeron 350; Eisai) for 12 s, followed by a 30 ml saline flush. Images were reconstructed with slice thickness and increment of 0.50 mm and 0.25 mm, respectively, using a convolution kernel of FC04 with iterative reconstruction (AIDR 3D [adaptive iterative dose reduction using a three-dimensional processing algorithm]; Canon Medical Systems Corporation). Images were transferred to a workstation for postprocessing (Synapse Vincent, version 6.0; Fujifilm Medical).
6
Abdominal CT Imaging Protocol
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All CT images were obtained using either a 64-channel scanner (SOMATOM Perspective, Siemens, n = 34) or a 128-channel scanner (SOMATOM Definition Flash, n = 32 or SOMATOM Definition AS+, Siemens, n = 36). The scanning protocol consisted of non-enhanced and biphasic contrast-enhanced scans. The non-enhanced phase was obtained through the upper abdomen, including the entire liver and pancreas. Then, a bolus of 600 mgI/kg of iodine contrast medium was administered using an automatic power injector at a rate of 2.0-3.0 ml/s for 33 seconds. The contrast media used included iohexol (Omnipaque 350 Injection, Daiichi Sankyo, n = 34 or IOVERIN 350, Teva Takeda Pharma, n = 25), iopamidol (Iopamiron 370 Inj., Bayer Yakuhin, n = 20 or Oypalomin 370 injection, Fuji Pharma, n = 18), or iomeprol (Iomeron 350, Eisai, n = 5). Arterial phase was obtained 10 seconds after reaching 80 Hounsfield units with the ROI placed on the aorta at the level of the celiac artery, while portal venous phase was obtained 90 seconds after triggering. The arterial and portal venous phases were obtained through the upper abdomen and through the whole abdomen, respectively.
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