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B6 bks d leprdb j b6 db db

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B6.BKS(D)-Leprdb/J (B6 db/db) is a mouse strain that carries a spontaneous mutation in the leptin receptor gene (Leprdb). This mutation results in obesity, hyperglycemia, and insulin resistance, which are characteristic features of type 2 diabetes. The B6 db/db mouse is a widely used model for studying the pathogenesis and potential treatments for metabolic disorders.

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Lab products found in correlation

C57bl 6ntac, by Taconic Biosciences (2 mentions) Balb canntac, by Taconic Biosciences (2 mentions) Wt c57bl 6 mice, by Jackson ImmunoResearch (2 mentions) D12492, by Research Diets (2 mentions) B6.129s6 rag2tm1fwa n12, by Taconic Biosciences (2 mentions) B6 cg lepob j ob ob mice, by Jackson ImmunoResearch (2 mentions)

2 protocols using b6 bks d leprdb j b6 db db

1

Mouse Models for Metabolic Disorders

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Mice were housed in AAALAC-accredited animal facilities at UC Davis under SPF conditions. Protocols were approved by UC Davis IACUC and studies complied with ethical regulations and humane endpoints. Male and female C57BL/6NTac, female BALB/cAnNTac and male B6.129S6-Rag2tm1Fwa N12 (Rag2−/−) mice were purchased from Taconic Farms at 4 weeks of age. Diet induced obese and control mice were generated by feeding mice with an open-source purified diet consisting of either 60% fat or 10% fat (D12492 & D12450J, Research Diets, Inc) respectively, starting when the mice were 6 weeks old. 4–8-week-old male B6.Cg-Lepob/J (ob/ob) mice and female B6.BKS(D)-Leprdb/J (B6 db/db) and WT C57BL/6 mice were purchased from Jackson Laboratory. ob/ob mice were used when they were 3–5 months old and equivalent in weight to 9-month-old DIO mice. 6–9-month-old BKS.Cg-Dock7m +/+ Leprdb/J (BSK db/db) were kind gifts from Dr. R. Rivkah Isseroff. The female NSG mice (4–5-month-old) were kind gifts from Dr. Jan Nolta. 19-month-old ad libitum (AL) and calorie restricted (CR) C57BL/6 mice were obtained from the National Institute on Aging and were fed NIH31 regular chow with a 40% calorie restriction regimen previously published40 (link).
Wang Z., Aguilar E.G., Luna J.I., Dunai C., Khuat L.T., Le C.T., Mirsoian A., Minnar C.M., Stoffel K.M., Sturgill I.R., Grossenbacher S.K., Withers S.S., Rebhun R.B., Hartigan-O’Connor D.J., Méndez-Lagares G., Tarantal A.F., Isseroff R.R., Griffith T.S., Schalper K.A., Merleev A., Saha A., Maverakis E., Kelly K., Aljumaily R., Ibrahimi S., Mukherjee S., Machiorlatti M., Vesely S.K., Longo D.L., Blazar B.R., Canter R.J., Murphy W.J, & Monjazeb A.M. (2018). Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nature medicine, 25(1), 141-151.
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2

Mouse Models for Metabolic Disorders

Check if the same lab product or an alternative is used in the 5 most similar protocols
Mice were housed in AAALAC-accredited animal facilities at UC Davis under SPF conditions. Protocols were approved by UC Davis IACUC and studies complied with ethical regulations and humane endpoints. Male and female C57BL/6NTac, female BALB/cAnNTac and male B6.129S6-Rag2tm1Fwa N12 (Rag2−/−) mice were purchased from Taconic Farms at 4 weeks of age. Diet induced obese and control mice were generated by feeding mice with an open-source purified diet consisting of either 60% fat or 10% fat (D12492 & D12450J, Research Diets, Inc) respectively, starting when the mice were 6 weeks old. 4–8-week-old male B6.Cg-Lepob/J (ob/ob) mice and female B6.BKS(D)-Leprdb/J (B6 db/db) and WT C57BL/6 mice were purchased from Jackson Laboratory. ob/ob mice were used when they were 3–5 months old and equivalent in weight to 9-month-old DIO mice. 6–9-month-old BKS.Cg-Dock7m +/+ Leprdb/J (BSK db/db) were kind gifts from Dr. R. Rivkah Isseroff. The female NSG mice (4–5-month-old) were kind gifts from Dr. Jan Nolta. 19-month-old ad libitum (AL) and calorie restricted (CR) C57BL/6 mice were obtained from the National Institute on Aging and were fed NIH31 regular chow with a 40% calorie restriction regimen previously published40 (link).
Wang Z., Aguilar E.G., Luna J.I., Dunai C., Khuat L.T., Le C.T., Mirsoian A., Minnar C.M., Stoffel K.M., Sturgill I.R., Grossenbacher S.K., Withers S.S., Rebhun R.B., Hartigan-O’Connor D.J., Méndez-Lagares G., Tarantal A.F., Isseroff R.R., Griffith T.S., Schalper K.A., Merleev A., Saha A., Maverakis E., Kelly K., Aljumaily R., Ibrahimi S., Mukherjee S., Machiorlatti M., Vesely S.K., Longo D.L., Blazar B.R., Canter R.J., Murphy W.J, & Monjazeb A.M. (2018). Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nature medicine, 25(1), 141-151.
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