B6j 129s6

Manufactured by Jackson ImmunoResearch

B6J.129S6 is a mouse strain that is homozygous for the Pde6b mutation, which causes retinal degeneration. This strain is commonly used in research applications involving the study of vision and retinal function.

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Lab products found in correlation

Vgat ires cre, by Jackson ImmunoResearch (3 mentions) C57bl 6j, by Jackson ImmunoResearch (3 mentions) Oprm1fl fl, by Jackson ImmunoResearch (2 mentions) B6 129 oprm1tm1.1cgrf kffj, by Jackson ImmunoResearch (2 mentions) B6 cg gt rosa 26sortm14 cag tdtomato hze j, by Jackson ImmunoResearch (2 mentions) Vglut2 ires cre, by Jackson ImmunoResearch (1 mentions) Vglut2 cre, by Jackson ImmunoResearch (1 mentions) Th cre, by Jackson ImmunoResearch (1 mentions)

3 protocols using b6j 129s6

Optogenetic Manipulation of Dopamine Neurons

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All procedures were performed in accordance with protocols approved by the University of California San Diego Institutional Animal Care and Use Committee (UCSD IACUC protocol S16171) and guidelines from the US National Institutes of Health Guide for Care and Use of Laboratory Animals. Mice were group housed, maintained on a 12-hour reversed light/dark cycle, and allowed ad libitum access to food and water. Experiments were performed under red lighting during the dark period. Strains used include the following: C57Bl/6J (Jackson Laboratory stock #664), DBH-cre (MMRRC/GENSAT #032081-UCD, Tg(DBH-cre)HK212Gsat/Mmucd), VGLUT2-IRES-cre (Jackson Laboratory stock #028863, B6J.129S6(FVB)-Slc17a6^tm2(cre)Lowl/MwarJ), and VGAT-IRES-cre (Jackson Laboratory stock #028862, B6J.129S6(FVB)-Slc32a1^tm2(cre)Lowl/MwarJ). Ai14 tdTomato (Jackson Laboratory stock #7914, B6.Cg-Gt(ROSA)^{26Sortm14(CAG-tdTomato)Hze}/J) and Oprm1^fl/fl (Jackson Laboratory stock #30074, B6;129-Oprm1^tm1.1Cgrf/KffJ) mice were also obtained from Jackson Labs, but bred in-house to DBH-cre mice. Mice were used for experiments between the ages of 8–20 weeks. Both male and female mice were used for all experiments.

Lubejko S.T., Livrizzi G., Patel J., Yung J.C., Yaksh T.L, & Banghart M.R. (2023). Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation. bioRxiv.

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Optogenetic Control of Dopamine and GABA Neurons

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All procedures were performed in accordance with protocols approved by the University of California, San Diego Institutional Animal Care and Use Committee (UCSD IACUC protocol S16171) and guidelines from the U.S. National Institutes of Health Guide for Care and Use of Laboratory Animals. Mice were group-housed, maintained on a 12-hour reversed light/dark cycle, and allowed ad libitum access to food and water. Experiments were performed under red lighting during the dark period. Strains used include the following: C57Bl/6J (The Jackson Laboratory, stock no. 664), Dbh-cre [MMRRC/GENSAT, no. 032081-UCD, Tg(DBH-cre)HK212Gsat/Mmucd], Slc17a6-IRES-cre [Vglut2-cre, The Jackson Laboratory, stock no. 028863, B6J.129S6(FVB)-Slc17a6^tm2(cre)Lowl/MwarJ], and Slc32a1-IRES-cre [Vgat-IRES-cre, The Jackson Laboratory, stock no. 028862, B6J.129S6(FVB)-Slc32a1^tm2(cre)Lowl/MwarJ]. Ai14 tdTomato [The Jackson Laboratory, stock no. 7914, B6.Cg-Gt(ROSA)^{26Sortm14(CAG-tdTomato)Hze}/J] and Oprm1^fl/fl (The Jackson Laboratory, stock no. 30074, B6;129-Oprm1^tm1.1Cgrf/KffJ) mice were also obtained from The Jackson Laboratory but bred in-house to Dbh-cre mice. Mice were used for experiments between the ages of 8 to 20 weeks. Both male and female mice were used for all experiments.

Lubejko S.T., Livrizzi G., Buczynski S.A., Patel J., Yung J.C., Yaksh T.L, & Banghart M.R. (2024). Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation. Science Advances, 10(17), eadj9581.

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Optogenetic Manipulation of Inhibitory Neurons

Cited 4 times

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All procedures were in accordance with protocols approved by the Johns Hopkins University Animal Care and Use Committee (protocols: MO18M187, MO21M195). Mice were housed in a room on a reverse light-dark cycle, with each phase lasting 12 hours, and maintained at 20–25°C and 30–70% humidity. Prior to surgery, mice were housed in groups of up to 5, but afterwards housed individually. Fifteen mice (12 male, 3 female) were obtained by crossing VGAT-IRES-Cre (Jackson Labs: 028862; B6J.129S6(FVB)-Slc32a1^tm2(cre)Lowl/MwarJ)^{42 (link)} with Ai32 (Jackson Labs: 012569; B6;129S-Gt(ROSA)26Sor^{tm32(CAG-COP4*H134R/EYFP)Hze}/J)^{43 (link)} lines. Two (1 male, 1 female) were heterozygous VGAT-ChR2-EYFP (Jackson Labs: 014548; B6.Cg-Tg(Slc32a1-COP4*H134R/EYFP)8Gfng/J)^{44 (link)} mice. Twelve (9 male, 3 female) were wild-type mice, including nine C57BL/6J (Jackson Labs: 000664) mice, one wild-type littermate for each of VGAT-ChR2-EYFP, TH-Cre (Jackson Labs: 008601; B6.Cg-7630403G23Rik^{Tg(TH-Cre)1Tmd}/J)^{45 (link)}, and Etv1-Cre−/− (Jackson Labs: 013048)^{46 (link)}. Two were male TH-Cre mice. Two (1 male, 1 female) were Advillin-Cre (Jackson Labs: 032536; B6.129P2-Avil^tm2(cre)Fawa/J)^{47 (link)} mice. Mice ranged in age from ~2–9 months at the start of training. A set of behavioural testing sessions typically lasted ~1 month (Supplementary Table 1).

Xu D., Dong M., Chen Y., Delgado A.M., Hughes N.C., Zhang L, & O’Connor D.H. (2022). Cortical processing of flexible and context-dependent sensorimotor sequences. Nature, 603(7901), 464-469.

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