Dicyclohexylcarbodiimide

Folic acid, 2-Hydroxy-1-ethanethiol, and dimethyl sulfoxide (DMSO) were purchased from Tianjin Guangcheng Chemical Reagent Co., Ltd. (Tianjin, China); ethanol, ethyl acetate, sodium hydroxide, oleylamine (OA), isooctane, ascorbic acid, bis (2-ethylhexyl) sulfosuccinate sodium (AOT, 98.0%), and dithiothreitol (DTT) were obtained from Macklin reagents Co., Ltd. (Shanghai, China); and sodium borohydride, Polyvinylpyrrolidone (PVP), silver nitrate, 4-dimethylaminopyridine (DMAP), Dicyclohexylcarbodiimide (DCC), and ammonia water were purchased from Sinopharm Chemical Reagent Co., Ltd. (Tianjin, China). All reagents were analytically pure and were used as received.

Medical-grade PLLA (Mη = 1 × 10⁵ g/mol) was supplied by Daigang Biomaterial Co. (Jinan, China). Cholesterol (purity ≥ 99.0%) was purchased from Aiwang Chemical Technology Co. (Shanghai, China). Undecylenic acid, chloroplatinic acid (H₂PtCl₆▪6H₂O), and polymethylhydrogensiloxane (PMHS, Mn = 697) were purchased from Shanghai Macklin Biochemical Co. (Shanghai, China). Dicyclohexylcarbodiimide (DCC), 4-dimethylaminopyridine (DMAP), N,N-dimethylformamide, toluene, dichloromethane (DCM), hydrochloric acid (HCl), sodium hydroxide (NaOH), sodium bicarbonate (NaHCO₃), anhydrous magnesium sulfate (MgSO₄), methanol, and ethanol were supplied by Sinopharm Chemical Reagent Co. (Shenyang, China). SBF (1.5 × SBF) was obtained from Xinhua Luyuan Technology Co., Ltd. (Beijing, China).