Discovery st pet ct

Manufactured by GE Healthcare

Sourced in United States

The Discovery ST PET/CT is a combined positron emission tomography (PET) and computed tomography (CT) imaging system manufactured by GE Healthcare. It is designed to acquire both functional and anatomical data in a single scanning session.

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Lab products found in correlation

Discovery mi scanner, by GE Healthcare (1 mentions) Ecat exact hr1, by Siemens (1 mentions)

Close spelling variants of this product

GE Discovery ST PET/CT Discovery ST PET/CT scanner Discovery ST 16 PET/CT scanner Discovery ST PET-CT system Discovery ST PET/CT camera Discovery ST PET/CT instrument Discovery ST

5 protocols using discovery st pet ct

Multimodal Neuroimaging Protocol for Alzheimer's

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T1-weighted 3D volumes were acquired (3T, Siemens AVANTO) for co-registration with positron emission tomography (PET) and to define the region of interest (ROI). Additionally, fluid-attenuated inversion recovery images were obtained for WMH readings.
PET scans were performed using a PET/CT scanner (Discovery ST PET/CT, GE) with a field of view of 250 mm, providing slices of 3.3 mm thickness and 256×256 matrix size. The brain 3D acquisition mode was used. Images were reconstructed from the data with ordered-subset expectation maximum iterative reconstruction algorithm (4 iterations, 32 subsets). After [18F]Florbetaben injection, subjects were allowed to wait for 90 min, and 47-slice images were acquired over 20 min. The injected dose was 300 MBq for every subject.

Choo I.H., Chong A., Chung J.Y., Ha J.M., Choi Y.Y, & Kim H. (2022). A Single Baseline Amyloid Positron Emission Tomography Could Be Sufficient for Predicting Alzheimer’s Disease Conversion in Mild Cognitive Impairment. Psychiatry Investigation, 19(5), 394-400.

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PET/CT Imaging Protocol for 18F-FDG Uptake

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For PET/CT, 12 mCi of ¹⁸F-FDG was injected into the patient in the fasted state (or after 6 h) nominally 1h before the scan. ¹⁸F-FDG-PET scans were acquired as part of a standard clinical whole-body protocol on a GE Discovery ST PET/CT in 3D mode. The protocol consists of acquiring a low dose whole body CT (80 mA at 120 kVp) followed by the ¹⁸F-FDG-PET scan using a dwell time of 3 m per bed and an 11-slice overlap (approximately 16 cm per bed) from mid-skull to upper thighs. PET images were reconstructed using 2 × 20 iterations and subsets, with axial 3-point smoothing (Heavy, [1 2 1]/4), and a transaxial Gaussian post-filter (6.0 mm full width at half maximum). Tracer uptake was represented by SUV normalized by body weight. Tumor regions of interest (ROIs) on PET were segmented in MIM^™ VISTA using a gradient-based autosegmentation method, and SUVmax was extracted from each tumor ROI. The median SUVmax for the population was 17.90 (range, 2.710 to 23.54).

Lee S.H., Rimner A., Gelb E., Deasy J.O., Hunt M.A., Humm J.L, & Tyagi N. (2018). Correlation Between Tumor Metabolism and Semiquantitative Perfusion MRI Metrics in Non-small Cell Lung Cancer. International journal of radiation oncology, biology, physics, 102(4), 718-726.

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PET Imaging of Monkey Brain Function

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After an overnight starvation, anesthesia of the monkey was induced by intramuscular injection of Domitor (0.1 mg/kg) and ketamine (0.1 mg/kg), following which the animal was ventilated through an endotracheal tube, and volatile anesthesia was maintained using isoflurane (1.5–2.0 % in O₂). Vascular access was prepared in the femoral vein for administration of [¹⁸F]FEtQ and saline, and the monkey was monitored continuously for body temperature, O₂ and CO₂ saturation, blood pressure, pulse, and breathing.
PET acquisition was carried out on a Discovery ST PET/CT (GE Healthcare, Milwaukee, WI, USA). The animal was placed in a supine position, and a CT transmission scan was carried out prior to the administration of [¹⁸F]FEtQ (94.2 MBq). A 15-min dynamic emission scan focusing on the thorax was started 10–15 s before [¹⁸F]FEtQ injection, followed by 3 additional whole-body static scans (10 min each). Scans were acquired in a two-dimensional model, normalized, and corrected for randoms, dead time, scatter, decay, and attenuation. Images were reconstructed using OSEM iterative reconstruction.

Grievink H., Shamni O., Krajewski S., Steczek Ł., Gründemann D., Mishani E, & Abourbeh G. (2022). Organic Cation Transporter-Mediated Accumulation of Quinolinium Salts in the LV Myocardium of Rodents. Molecular Imaging and Biology, 24(5), 1-9.

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11C-PIB PET/CT Imaging Protocol

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After a respiration-averaged low-dose CT scan, a 35-minute dynamic emission scan of the heart was started simultaneously with intravenous bolus injection of ¹¹C-PIB (5 MBq/kg) on a Discovery ST PET/CT (subject 1-6) or Discovery MI scanner (subject 7-8) (GE Healthcare). Recovery was matched in the two scanners based on previous measurements with a NEMA image quality phantom. Imaging was performed in 3D-mode. All appropriate corrections for normalization, dead time, decay, scatter, randoms and attenuation were applied. Images were reconstructed into 31 frames (12×5, 6×10, 4×30, 2×60, 2×120 and 5×300 seconds) using ordered subset expectation maximization (OSEM) with 2 iterations and 21 subsets (Discovery ST) or time-of-flight OSEM with 3 iterations and 16 subsets (Discovery MI) and a 5 mm gaussian post-filter. Images consisted of 128×128 voxels, with dimensions of 2.34×2.34×3.27 mm (Discovery ST) and 2.34×2.34×2.79 mm (Discovery MI), and a spatial resolution of approximately 7 mm.

Kero T., Sörensen J., Antoni G., Wilking H., Carlson K., Vedin O., Rosengren S., Wikström G, & Lubberink M. (2018). Quantification of 11C-PIB kinetics in cardiac amyloidosis. Journal of Nuclear Cardiology, 27(3), 774-784.

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Multimodal PET and MRI Imaging Protocol

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Image Acquisition and Processing. Participants underwent 11 C-DED, 11 C-PiB, and 18 F-FDG PET examinations at the Uppsala PET Center on ECAT EXACT HR1 (Siemens/CTI) and Discovery ST PET/CT (GE Healthcare) scanners. The tracers were produced, and the PET and MR image acquisition and processing methods were set as previously described (15) . Briefly, the T1 MR image for each participant was coregistered onto the individual's 10-to 60-min late-sum 11 C-DED image using SPM8 (Wellcome Trust Centre for Neuroimaging at UCL); 40-to 60-min 11 C-PiB and 30-to 45-min 18 F-FDG late-sum images were coregistered onto the T1 MR image (which had been previously coregistered to 11 C-DED space). A simplified probabilistic atlas (22) consisting of 12 bilateral regions of interest (ROIs) was registered from the Montreal Neurologic Institute space onto the subject's 11 C-DED space and was masked using individual GM masks. Registered 18 F-FDG and 11 C-PiB PET images were sampled using these individual cortical atlases; the whole pons was used as a reference.

Rodriguez-Vieitez E., Carter S.F., Chiotis K., Saint-Aubert L., Leuzy A., Schöll M., Almkvist O., Wall A., Långström B, & Nordberg A. (2016). Comparison of Early-Phase 11C-Deuterium-l-Deprenyl and 11C-Pittsburgh Compound B PET for Assessing Brain Perfusion in Alzheimer Disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 57(7).

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