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N 2 quinolyl valyl aspartyl 2 6 difluorophenoxy methyl ketone qvd

Manufactured by Selleck Chemicals
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Sourced in Germany, United States

N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl ketone (QVD) is a synthetic chemical compound. It functions as a broad-spectrum inhibitor of caspases, a family of enzymes involved in programmed cell death or apoptosis.

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Lab products found in correlation

Etoposide, by Abcam (2 mentions) Carbonyl cyanide m chlorophenyl hydrazone, by Merck Group (1 mentions) Sodium azide nan3, by Merck Group (1 mentions) Paclitaxel, by Merck Group (1 mentions) Antimycin a, by Merck Group (1 mentions) Potassium cyanide, by Merck Group (1 mentions) Chloramphenicol, by Merck Group (1 mentions) Rotenone, by Merck Group (1 mentions) Cycloheximide (chx), by Carl Roth (1 mentions) Tigecycline, by Merck Group (1 mentions) Clotrimazol, by Merck Group (1 mentions) Lonidamine, by Merck Group (1 mentions) Thenoyltrifluoroacetone ttfa, by Merck Group (1 mentions) Staurosporine, by LC Laboratories (1 mentions)

2 protocols using n 2 quinolyl valyl aspartyl 2 6 difluorophenoxy methyl ketone qvd

1

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Antimycin A (#A8674), carbonyl cyanide m-chlorophenyl hydrazone (CCCP, #C2759), chloramphenicol (#C0378-5G), clotrimazol (#C6019), lonidamine (#L4900), paclitaxel (#T7402), potassium cyanide (#60178), rotenone (#45656), sodium azide (NaN3, #S200), thenoyltrifluoroacetone (TTFA, #88300), tigecycline (#220620097) and vinblastine (VBL, #V1377) were purchased from Sigma (Munich, Germany), cycloheximide (#8682.1) from Roth (Karlsruhe, Germany), N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl ketone (QVD, #S7311) from Selleckchem (Houston, TX, USA), oligomycin A (#O532970) from Toronto Research Chemicals (Toronto, Canada), etoposide (#1043) from Biovision and staurosporine (STS, #9300) from LC Laboratories (Woburn, MA, USA). All other substances for which a manufacturer is not explicitly specified were obtained from Carl Roth.
Stuhldreier F., Schmitt L., Lenz T., Hinxlage I., Zimmermann M., Wollnitzke P., Schliehe-Diecks J., Liu Y., Jäger P., Geyh S., Teusch N., Peter C., Bhatia S., Haas R., Levkau B., Reichert A.S., Stühler K., Proksch P., Stork B, & Wesselborg S. (2022). The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism. Cell Death & Disease, 13(11), 938.
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2

Inducing Apoptosis with STS, QVD, and Etoposide

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Staurosporine (STS, #9300) was obtained from LC Laboratories (Woburn, MA, USA), N-(2-quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl ketone (QVD, #S7311) from Selleckchem (Houston, TX, USA) and Etoposide from BioVision (#1043-100).
Schmitt L., Hinxlage I., Cea P.A., Gohlke H, & Wesselborg S. (2021). 40 Years of Research on Polybrominated Diphenyl Ethers (PBDEs)—A Historical Overview and Newest Data of a Promising Anticancer Drug. Molecules, 26(4), 995.
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