The human PD-L1 (13684) Rabbit mAb, c-JUN (60A8) Rabbit mAb (9165S), Phospho-JNK (Thr183/Tyr185) (81E11) Rabbit mAb (4668T), Phospho-c-JUN (Ser63) II Antibody (9261S), NAE1 Rabbit mAb (14321S), p-ERK1/2 Rabbit mAb (4376S), ERK1/2 Mouse mAb (9106S), p-AKT Rabbit mAb (4060S), AKT Rabbit mAb (4691S), β-CATENIN Rabbit mAb (8480S), Cleaved-PARP Rabbit mAb (9541S) Cleaved-Caspase3 Rabbit mAb (9661S) and Phospho-c-FOS (Ser32) (5348T) were purchased from Cell Signaling Technology. UBA3 (ab124728) Rabbit mAb was purchased from Abcam. Mouse PD-L1 antibody (MAB90781-100) was purchased from R&D Systems. APC-conjugated anti-human PD-L1 (329708), APC anti-mice CD3 (100235), FITC anti-h/m Gramzyme B (515403), PE anti-mIFN-γ (505808), FITC-anti-mCD4 (10509), PE anti-mCD8a (100707), Fixation Buffer (420801) and Permeabilization Wash Buffer (10×) (421002) were purchased from Biolegend. Collagenase (C0130-500MG), β-ACTIN Mouse mAb (A5441) was purchased from Sigma. MEK inhibitor (trametinib) and JNK inhibitor (SP600125) were purchased from MedChem Express. AKT inhibitor (MK2206) and MLN4924 (S7109) were purchased from Selleck.
Mln4924 s7109
Manufactured by Selleck Chemicals
MLN4924 (S7109) is a chemical compound used as a laboratory tool for research purposes. It functions as a selective inhibitor of the NEDD8-activating enzyme, which plays a role in the regulation of protein ubiquitination and degradation. This product is intended for use in scientific research, and its specific applications should be evaluated by qualified professionals.
Automatically generated - may contain errors
Lab products found in correlation
Cleaved parp, by Cell Signaling Technology (1 mentions)
Trametinib, by MedChemExpress (1 mentions)
β catenin, by Cell Signaling Technology (1 mentions)
Mouse pd l1 antibody mab90781 100, by R&D Systems (1 mentions)
Akt inhibitor mk 2206, by Selleck Chemicals (1 mentions)
Sp600125, by MedChemExpress (1 mentions)
Dmem f12, by Thermo Fisher Scientific (1 mentions)
Dulbecco modified eagle medium (dmem), by Thermo Fisher Scientific (1 mentions)
Iscove modified dulbecco media (imdm), by Thermo Fisher Scientific (1 mentions)
Roswell park memorial institute (rpmi), by Thermo Fisher Scientific (1 mentions)
Thpta, by Lumiprobe (1 mentions)
2 protocols using mln4924 s7109
1
Comprehensive Signaling Pathway Analysis
2
Comprehensive Cell Culture Reagents
Check if the same lab product or an alternative is used in the 5 most similar protocols
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All cell culture media and fetal bovine serum (DMEM, IMDM, RPMI, DMEM/F-12) were purchased from Gibco unless otherwise specified. Primary antibodies for GAPDH (2118S), Vinculin (13901S), brachyury (81694S), HA-tag (3724S), protein A magnetic beads (73778S) and streptavidin magnetic beads (5947S) were purchased from Cell Signaling Technologies. Primary antibody for c-Myc (sc-40) was purchased from Santa Cruz. Secondary rabbit (NA934) and mouse (NA931) antibodies were purchased from GE Health Care. RNAiMAX (13778-150) transfecting reagent was purchased from Thermo Fisher Scientific. MLN4924 (S7109) was purchased from Selleckchem. Copper (II) sulfate pentahydrate (209198) and L-Ascorbic acid (A4403) were purchased from Millipore Sigma, and THPTA purchased from Lumiprobe (H4050). All the oligonucleotide modifiers were purchased from Glen Research, 3' Alkyne (20-2992-41), 5' Alkyne (10-1992-90 ) and biotin (10-5950-90) . All the oligonucleotides were custom synthesized by Yale Keck oligo synthesis facility.
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