Tcs sulfate

Manufactured by Santa Cruz Biotechnology

TCS sulfate is a laboratory reagent that is commonly used in various biochemical and cell biology applications. It functions as a selective inhibitor of the enzyme DNA topoisomerase I, which is involved in the regulation of DNA topology. The core function of TCS sulfate is to facilitate the study of cellular processes that are dependent on DNA topoisomerase I activity.

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Lab products found in correlation

Penicillin streptomycin, by Thermo Fisher Scientific (2 mentions) Trans 2 3 4 tert butylphenyl 2 methyl 2 propenylidene malononitrile dctb, by Merck Group (1 mentions) Trypsin 0.25, by Thermo Fisher Scientific (1 mentions) 13c12 tcs, by Cambridge Isotopes (1 mentions) Acetonitrile, by Merck Group (1 mentions) Ammonium acetate, by Merck Group (1 mentions) Chloroform, by Merck Group (1 mentions) Formic acid, by Merck Group (1 mentions)

2 protocols using tcs sulfate

Comprehensive Mass Spectrometry Protocol

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Chloroform, acetonitrile (ACN),
methanol (MeOH), ammonium acetate, ethanol (EtOH), dichloromethane
(DCM), formic acid, and isopropanol (IPA) were from Merck (Darmstadt,
Germany). Trypsin (0.25%), Dulbecco’s modified eagle medium
(DMEM), dimethyl sulfoxide (DMSO), 4-chloro-phenylalanine (4-Cl-Phe),
fetal bovine serum (FBS), collagen I, and penicillin–streptomycin
(100 U/mL) were from Thermo Fisher (Cambridge, MA, U.S.A.). trans-2-[3-(4-tert-Butylphenyl)-2-methyl-2-propenylidene]malononitrile
(DCTB), 2,5-dihydroxybenzoic acid (DHB), orlistat, and 9-acridinamine
(9AA) were from Sigma-Aldrich (St. Louis, MO, U.S.A.). Phosphatidylcholine(19:0/19:0)
(PC(19:0/19:0)), triglyceride(15:0/15:0/15:0) (TG(15:0/15:0/15:0)),
and sphingomyelin(d18:1/12:0) (SM(d18:1/12:0)) were obtained from
Avanti Polar Lipids (Alabaster, AL, U.S.A.). TCS glucuronide (TCSG,
95%) and TCS sulfate (TCSS, 95%) were purchased from Santa Cruz Biotechnology
(Dallas, TX, U.S.A). TCS (99%) was brought from Alfa Aesar (Haverhill,
MA, U.S.A). ¹³C₁₂-TCS was purchased from Cambridge
Isotope Laboratories (Andover, MA, U.S.A).

Chen J., Xie P., Wu P., Lin Z., He Y, & Cai Z. (2023). Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan. Environmental Science & Technology, 57(29), 10542-10553.

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Triclosan and Its Metabolites Analysis

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Triclosan (TCS, 99% purity) was purchased from Alfa Aesar (Haverhill, MA). TCS-glucuronide (TCS-G, 95% purity) and TCS-sulfate (95% purity) were from Santa Cruz Biotechnology (Dallas, TX). Stable isotope-labeled triclosan (¹³C₁₂-TCS, 99% purity) was obtained from Cambridge Isotope Laboratories (Andover, MA).

Zhang J., Walker M.E., Sanidad K.Z., Zhang H., Liang Y., Zhao E., Chacon-Vargas K., Yeliseyev V., Parsonnet J., Haggerty T.D., Wang G., Simpson J.B., Jariwala P.B., Beaty V.V., Yang J., Yang H., Panigrahy A., Minter L.M., Kim D., Gibbons J.G., Liu L., Li Z., Xiao H., Borlandelli V., Overkleeft H.S., Cloer E.W., Major M.B., Goldfarb D., Cai Z., Redinbo M.R, & Zhang G. (2022). Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nature Communications, 13, 136.

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