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Ly341495 disodium salt

Manufactured by Bio-Techne
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LY341495 disodium salt is a chemical compound used in laboratory research. It is a selective antagonist of metabotropic glutamate receptors (mGluRs). The compound can be used to study the role of mGluRs in various biological processes.

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Lab products found in correlation

Ana 12, by Bio-Techne (2 mentions) Ly379268 disodium salt, by Bio-Techne (2 mentions) R ketamine hydrochloride, by Cayman Chemical (2 mentions) Pcp hydrochloride, by Merck Group (1 mentions) 7 8 dhf, by Bio-Techne (1 mentions) Brain derived neurotrophic factor (bdnf), by Bio-Techne (1 mentions) S ketamine hydrochloride, by Bio-Techne (1 mentions) Nbqx disodium salt, by Bio-Techne (1 mentions) Mk 801 hydrogen maleate, by Merck Group (1 mentions) Naloxone hydrochloride dihydrate, by Merck Group (1 mentions) Skf38393 hydrobromide, by Bio-Techne (1 mentions) 2 5 dimethoxy 4 iodoamphetamine hydrochloride, by Merck Group (1 mentions) Morphine sulphate pentahydrate, by Merck Group (1 mentions) R apomorphine hydrochloride hemihydrate, by Merck Group (1 mentions)

4 protocols using ly341495 disodium salt

1

Pharmacological Agents for Neuroscience Research

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LY379268 disodium salt (#5064), LY341495 disodium salt (#5062), ANA12 (#4781), and BDNF (#2837) were from Tocris. 7,8-DHF (#D5446) and PCP hydrochloride (#P3029) were from Sigma-Aldrich.
Philibert C.E., Disdier C., Lafon P.A., Bouyssou A., Oosterlaken M., Galant S., Pizzoccaro A., Tuduri P., Ster J., Liu J., Kniazeff J., Pin J.P., Rondard P., Marin P, & Vandermoere F. (2024). TrkB receptor interacts with mGlu2 receptor and mediates antipsychotic-like effects of mGlu2 receptor activation in the mouse. Science Advances, 10(4), eadg1679.
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2

Pharmacological Characterization of Ketamine

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(S)-(+)-Ketamine hydrochloride (Tocris Cookson, Ltd., Bristol, UK), (R)-ketamine hydrochloride (Cayman Chemicals, Ann Arbor, USA), LY341495 disodium salt (Tocris Cookson, Ltd.), NBQX disodium salt (Tocris Cookson Ltd.), LY379268 disodium salt (Tocris Cookson, Ltd.) and ketamine hydrochloride solution (Bioketan, Biowet, Puławy, Poland) were diluted with 0.9% NaCl. ANA-12 (Tocris Cookson Ltd.) was dissolved in 2% DMSO. Herein, 0.9% NaCl or 2% DMSO was used as a vehicle. All compounds and vehicles were injected intraperitoneally (i.p.) at a constant volume of 10 mL/kg.
Rafało-Ulińska A., Brański P, & Pałucha-Poniewiera A. (2022). Combined Administration of (R)-Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Induces Rapid and Sustained Effects in the CUMS Model of Depression via a TrkB/BDNF-Dependent Mechanism. Pharmaceuticals, 15(2), 125.
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3

Pharmacological Agents for Neural Research

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(±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride (DOI), (+)-MK801 hydrogen maleate (dizocilpine), and R-(−)-apomorphine hydrochloride hemihydrate, morphine sulphate pentahydrate and naloxone hydrochloride dihydrate were purchased from Sigma Aldrich; LY341495 disodium salt and (±)-SKF38393 hydrobromide were purchased from Tocris. LY404039 (pomaglumetad) was purchased from Selleckchem. All drugs were dissolved in saline (0.9% NaCl) to the appropriate volume (0.005–0.01 ml/g body weight) and concentration for administration (i.p.). Vehicle-treated condition denotes injection of saline (i.p.) to the equivalent volume of the drug administered.
de la Fuente Revenga M., Shin J.M., Vohra H.Z., Hideshima K.S., Schneck M., Poklis J.L, & González-Maeso J. (2019). Fully automated head-twitch detection system for the study of 5-HT2A receptor pharmacology in vivo. Scientific Reports, 9, 14247.
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4

Intraperitoneal Injection of R-Ketamine and LY341495

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(R)-Ketamine hydrochloride (Cayman Chemicals, Ann Arbor, MI, USA) and LY341495 disodium salt (Tocris Cookson, Ltd., Bristol, UK) were diluted with 0.9% NaCl. The compounds and vehicles were injected intraperitoneally (i.p.) in a constant volume of 10 mL/kg.
Pałucha-Poniewiera A., Bobula B, & Rafało-Ulińska A. (2023). The Antidepressant-like Activity and Cognitive Enhancing Effects of the Combined Administration of (R)-Ketamine and LY341495 in the CUMS Model of Depression in Mice Are Related to the Modulation of Excitatory Synaptic Transmission and LTP in the PFC. Pharmaceuticals, 16(2), 288.
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