Dexolve

Manufactured by Cyclolab

Sourced in Hungary, France

Dexolve is a laboratory centrifuge designed for general-purpose applications. It features a compact and durable construction, providing reliable and efficient sample separation and processing. The centrifuge accommodates a variety of sample tubes and microplates, making it a versatile tool for a range of laboratory workflows.

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Lab products found in correlation

Mannitol, by Merck Group (1 mentions) β cyclodextrin, by Merck Group (1 mentions) Cahpo4, by Merck Group (1 mentions) Explotab, by JRS Pharma (1 mentions) Mg stearate, by Merck Group (1 mentions) Polyvinylpyrrolidone pvp k90, by Merck Group (1 mentions)

2 protocols using dexolve

Remdesivir Solubility Enhancement

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Remdesivir (REM) with a chemical purity of 99.2 % was purchased from Echemi Pharma, Qingdao, China.
Sulfobutylether-beta-cyclodextrin (SBECD) Dexolve™ (USP Betadex Sulfobutyl Ether Sodium) was a product of CycloLab, Budapest, Hungary. Five commercially available SBECD samples from different sources were involved in the comparative solubility enhancement studies and used as received. All these samples met the quality requirements set for pharmaceutical grade USP Betadex Sulfobutyl Ether Sodium – SBECD. The samples will be marked as source No. 1.-2.-3.-4.-5.

Szente L., Puskás I., Sohajda T., Varga E., Vass P., Nagy Z.K., Farkas A., Várnai B., Béni S, & Hazai E. (2021). Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and lyophilized formulations. Carbohydrate Polymers, 264, 118011.

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Nebivolol Hydrochloride Formulation

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Nebivolol HCl (NEB) (2,2′-Azanediylbis(1-(6-fluorochroman-2-yl) ethanol) hydrochloride) was a kind gift from Menarini S.p.a. (L’Aquila, Italy). Beta-cyclodextrin (βCD) was from Sigma (St. Louis, MO, USA). Hydroxypropyl-βCD (HPβCD, average substitution degree 0.62) was kindly supplied by Roquette (Lestrem, France), and sulfobutylether-βCD (Dexolve^®) (SBEβCD, average substitution degree 6.5) was a kind gift from Cyclolab Ltd. (Budapest, Hungary). Randomly substituted methyl-βCD (RAMEB, average substitution degree 1.8) was from Wacker Chemie (München, Germany). Explotab^® (sodium starch glycolate) was from JRS Pharma (Rosenberg, Germany), and Mg stearate, polyvinylpyrrolidone (PVP) K90, mannitol and CaHPO₄ were from Sigma (St. Louis, MO, USA). All other chemicals and solvents were of analytical reagent grade.

Maestrelli F., Cirri M., Mennini N., Fiani S., Stoppacciaro B, & Mura P. (2024). Development of Oral Tablets of Nebivolol with Improved Dissolution Properties, Based on Its Combinations with Cyclodextrins. Pharmaceutics, 16(5), 633.

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