Cilengitide

The miR‐148a‐3p and Cy3‐miR‐148a‐3p were synthesized by Tsing Biotechnology Co., Ltd (Beijing, China). The polypeptide materials RRRRPLGLAGRRRR (RR14), RGDGSRRRRPLGLAGRRRR (RR19), RGDGSRRRRRRRRGSRGD (RR18), and RGDGSRRRRPLGLAGRRRRGSRGD (RD24) were synthesized by GL Biochem (Shanghai) Ltd (Shanghai, China). Human lung cancer cell lines A549, NCI‐H1299, NCI‐H460, and human lung epithelial cell line BEAS‐2B were from the Cell Bank of the Chinese Academy of Sciences. The αvβ3 integrin receptor antagonist (Cilengitide) was bought from FineTest (Wuhan, China). The fetal bovine serum (FBS) was from Inner Mongolia Opcel Biotechnology (Hohhot, China). Dulbecco's modified eagle medium (DMEM), phosphate buffer solution (PBS), RNase‐free water, and penicillin–streptomycin were the products of Gibco (Grand Island, NY, USA).
Male BALB/c nude mice (6 weeks) were obtained from Guangdong Medical Lab Animal Center. All the animal experiments were approved and supervised by the Animal Experiment Ethics Committee of Guangzhou Medical University (SYK2016‐0168, GY2021‐131).

The miR‐148a‐3p and Cy3‐miR‐148a‐3p were synthesized by Tsing Biotechnology Co., Ltd (Beijing, China). The polypeptide materials RRRRPLGLAGRRRR (RR14), RGDGSRRRRPLGLAGRRRR (RR19), RGDGSRRRRRRRRGSRGD (RR18), and RGDGSRRRRPLGLAGRRRRGSRGD (RD24) were synthesized by GL Biochem (Shanghai) Ltd (Shanghai, China). Human lung cancer cell lines A549, NCI‐H1299, NCI‐H460, and human lung epithelial cell line BEAS‐2B were from the Cell Bank of the Chinese Academy of Sciences. The αvβ3 integrin receptor antagonist (Cilengitide) was bought from FineTest (Wuhan, China). The fetal bovine serum (FBS) was from Inner Mongolia Opcel Biotechnology (Hohhot, China). Dulbecco's modified eagle medium (DMEM), phosphate buffer solution (PBS), RNase‐free water, and penicillin–streptomycin were the products of Gibco (Grand Island, NY, USA).
Male BALB/c nude mice (6 weeks) were obtained from Guangdong Medical Lab Animal Center. All the animal experiments were approved and supervised by the Animal Experiment Ethics Committee of Guangzhou Medical University (SYK2016‐0168, GY2021‐131).

The miR‐148a‐3p and Cy3‐miR‐148a‐3p were synthesized by Tsing Biotechnology Co., Ltd (Beijing, China). The polypeptide materials RRRRPLGLAGRRRR (RR14), RGDGSRRRRPLGLAGRRRR (RR19), RGDGSRRRRRRRRGSRGD (RR18), and RGDGSRRRRPLGLAGRRRRGSRGD (RD24) were synthesized by GL Biochem (Shanghai) Ltd (Shanghai, China). Human lung cancer cell lines A549, NCI‐H1299, NCI‐H460, and human lung epithelial cell line BEAS‐2B were from the Cell Bank of the Chinese Academy of Sciences. The αvβ3 integrin receptor antagonist (Cilengitide) was bought from FineTest (Wuhan, China). The fetal bovine serum (FBS) was from Inner Mongolia Opcel Biotechnology (Hohhot, China). Dulbecco's modified eagle medium (DMEM), phosphate buffer solution (PBS), RNase‐free water, and penicillin–streptomycin were the products of Gibco (Grand Island, NY, USA).
Male BALB/c nude mice (6 weeks) were obtained from Guangdong Medical Lab Animal Center. All the animal experiments were approved and supervised by the Animal Experiment Ethics Committee of Guangzhou Medical University (SYK2016‐0168, GY2021‐131).