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C57bl 6 staggerer rorα sg

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The C57BL/6 staggerer (RORα+/sg) is a laboratory mouse strain that carries a mutation in the RORα gene, resulting in the staggerer phenotype. This strain is commonly used in research to study the role of the RORα gene in various biological processes.

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2 protocols using c57bl 6 staggerer rorα sg

1

Staggerer Mice Models in Metabolic Studies

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Heterozygous C57BL/6 staggerer (RORα+/sg) were obtained from the Jackson Laboratory (Bar Harbor, ME). RORγ−/− and RORαsg/sgRORγ−/− double knockout (DKO) mice were described previously (16 (link),23 (link)). Liver-specific RORγ knockout mice, referred to as RORγfx/fxAlb-Cre+, were described previously (22 (link)). Mice were supplied ad libitum with NIH-A31 formula (normal diet, ND) and water, and maintained at 23°C on a constant 12 h light:12 h dark cycle. Two month-old male mice were fed with a high fat diet (40% kcal fat) (HFD: D12079B Research Diets Inc., New Brunswick, NJ) for 6 weeks. Littermate wild-type (WT) mice were used as controls. All animal protocols followed the guidelines outlined by the NIH Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care and Use Committee at the NIEHS.
Takeda Y., Kang H.S., Lih F.B., Jiang H., Blaner W.S, & Jetten A.M. (2014). Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes. Nucleic Acids Research, 42(16), 10448-10459.
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2

Dietary Impact on RORα and RORγ Knockout Mice

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Heterozygous C57BL/6 staggerer (RORα+/sg) were obtained from the Jackson Laboratories (Bar Harbor, ME). RORγ−/− and RORαsg/sgRORγ−/− double knockout (DKO) mice were described previously [10] (link), [36] (link). Liver-specific RORγ knockout mice, referred to as RORγfx/fxAlb-Cre+, were generated by crossing B6(Cg)-Rorctm3Litt/J (RORγfx/fx) with B6.Cg-Tg(Alb-cre)21Mgn/J transgenic mice (Jackson Laboratories). Mice were supplied ad libitum with NIH-A31 formula (normal diet, ND) and water, and maintained at 23°C on a constant 12 h light∶12 h dark cycle. Two month-old male mice were fed with a high fat diet (40% kcal fat) (HFD: D12079B Research Diets Inc., New Brunswick, NJ) for 6 weeks. Littermate wild type (WT) mice were used as controls. All animal protocols followed the guidelines outlined by the NIH Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care and Use Committee at the NIEHS.
Takeda Y., Kang H.S., Freudenberg J., DeGraff L.M., Jothi R, & Jetten A.M. (2014). Retinoic Acid-Related Orphan Receptor γ (RORγ): A Novel Participant in the Diurnal Regulation of Hepatic Gluconeogenesis and Insulin Sensitivity. PLoS Genetics, 10(5), e1004331.
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