3.0 tesla mri scanner

High-resolution T1-weighted anatomic scans were acquired on a GE 3.0 Tesla MRI scanner before the overnight sleep recording (BRAVO; TR = 6.70 ms; TE = 2.93 ms; TI = 450 ms; flip angle = 12°; FOV = 256 mm; acquisition voxel size = 1 × 1 × 1 mm).

CMR was performed with a 3.0 Tesla MRI scanner (General Electric, Waukesha, WI, United States) (Morgan et al., 2018 (link)) both before and 3 months after PCI. CMR included 4 pulse sequences. Specifically, Cine-CMR was performed with a steady-state free precession pulse sequence. Images were acquired in contiguous LV short axis and standard (2-, 3- and 4-chamber) long axis orientations (Figure 2A). SP-CMR was assessed in accordance with established methods previously validated by members of our group (Klem et al., 2006 (link); Heitner et al., 2019 (link)). In brief, pharmacologic stress was induced with regadenoson (0.4 mg), during which gadolinium was infused (0.1 mmol/kg) and LV short axis images (4–5, evenly distributed from base-apex) were acquired using a gradient echo pulse sequence (Figure 2B). Perfusion CMR was repeated 5-min thereafter under baseline (non-stress) conditions. Myocardial infarction (LGE-CMR) was assessed using an inversion recovery pulse sequence, which was acquired 10–30 min post-gadolinium (0.2 mmol/kg) infusion and acquired in spatial orientations matched to Cine-CMR (Figure 2C). CSPAMM in contiguous LV short and long axis slices (8 mm tag spacing, 10 mm slice thickness, no gap) was performed to measure myocardial deformation and strain (Figure 2D).