Oprm1fl fl

Manufactured by Jackson ImmunoResearch

Oprm1fl/fl is a lab equipment product that serves as a tool for genetic research. It provides a method for conditional gene targeting in mice, specifically for the Oprm1 gene which is involved in opioid receptor signaling. The product allows for the creation of mouse models with tissue-specific or inducible deletion of the Oprm1 gene, enabling researchers to study its role in various biological processes.

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Lab products found in correlation

B6j 129s6, by Jackson ImmunoResearch (2 mentions) B6 129 oprm1tm1.1cgrf kffj, by Jackson ImmunoResearch (2 mentions) Vgat ires cre, by Jackson ImmunoResearch (2 mentions) B6 cg gt rosa 26sortm14 cag tdtomato hze j, by Jackson ImmunoResearch (2 mentions) C57bl 6j, by Jackson ImmunoResearch (2 mentions) Vglut2 ires cre, by Jackson ImmunoResearch (1 mentions) Ai14 tdtomato, by Jackson ImmunoResearch (1 mentions) Vglut2 cre, by Jackson ImmunoResearch (1 mentions)

2 protocols using oprm1fl fl

Optogenetic Manipulation of Dopamine Neurons

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All procedures were performed in accordance with protocols approved by the University of California San Diego Institutional Animal Care and Use Committee (UCSD IACUC protocol S16171) and guidelines from the US National Institutes of Health Guide for Care and Use of Laboratory Animals. Mice were group housed, maintained on a 12-hour reversed light/dark cycle, and allowed ad libitum access to food and water. Experiments were performed under red lighting during the dark period. Strains used include the following: C57Bl/6J (Jackson Laboratory stock #664), DBH-cre (MMRRC/GENSAT #032081-UCD, Tg(DBH-cre)HK212Gsat/Mmucd), VGLUT2-IRES-cre (Jackson Laboratory stock #028863, B6J.129S6(FVB)-Slc17a6^tm2(cre)Lowl/MwarJ), and VGAT-IRES-cre (Jackson Laboratory stock #028862, B6J.129S6(FVB)-Slc32a1^tm2(cre)Lowl/MwarJ). Ai14 tdTomato (Jackson Laboratory stock #7914, B6.Cg-Gt(ROSA)^{26Sortm14(CAG-tdTomato)Hze}/J) and Oprm1^fl/fl (Jackson Laboratory stock #30074, B6;129-Oprm1^tm1.1Cgrf/KffJ) mice were also obtained from Jackson Labs, but bred in-house to DBH-cre mice. Mice were used for experiments between the ages of 8–20 weeks. Both male and female mice were used for all experiments.

Lubejko S.T., Livrizzi G., Patel J., Yung J.C., Yaksh T.L, & Banghart M.R. (2023). Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation. bioRxiv.

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Optogenetic Control of Dopamine and GABA Neurons

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All procedures were performed in accordance with protocols approved by the University of California, San Diego Institutional Animal Care and Use Committee (UCSD IACUC protocol S16171) and guidelines from the U.S. National Institutes of Health Guide for Care and Use of Laboratory Animals. Mice were group-housed, maintained on a 12-hour reversed light/dark cycle, and allowed ad libitum access to food and water. Experiments were performed under red lighting during the dark period. Strains used include the following: C57Bl/6J (The Jackson Laboratory, stock no. 664), Dbh-cre [MMRRC/GENSAT, no. 032081-UCD, Tg(DBH-cre)HK212Gsat/Mmucd], Slc17a6-IRES-cre [Vglut2-cre, The Jackson Laboratory, stock no. 028863, B6J.129S6(FVB)-Slc17a6^tm2(cre)Lowl/MwarJ], and Slc32a1-IRES-cre [Vgat-IRES-cre, The Jackson Laboratory, stock no. 028862, B6J.129S6(FVB)-Slc32a1^tm2(cre)Lowl/MwarJ]. Ai14 tdTomato [The Jackson Laboratory, stock no. 7914, B6.Cg-Gt(ROSA)^{26Sortm14(CAG-tdTomato)Hze}/J] and Oprm1^fl/fl (The Jackson Laboratory, stock no. 30074, B6;129-Oprm1^tm1.1Cgrf/KffJ) mice were also obtained from The Jackson Laboratory but bred in-house to Dbh-cre mice. Mice were used for experiments between the ages of 8 to 20 weeks. Both male and female mice were used for all experiments.

Lubejko S.T., Livrizzi G., Buczynski S.A., Patel J., Yung J.C., Yaksh T.L, & Banghart M.R. (2024). Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation. Science Advances, 10(17), eadj9581.

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