Ortho nitrophenyl octyl ether o npoe

Tolperisone HCl pure drug was purchased from Combi-Blocks, USA. MYDOCALM^® tablets labeled to contain 150 mg tolperisone HCl manufactured by labatec-pharma SA (Geneva), Switzerland, were obtained from local pharmacy. Paramol^® 500 mg tablets labeled to contain 500 mg paracetamol was from (Misr Co for Pharm. Ind.S.A.E., Cairo, Egypt). Voltaren^®50 tablets labeled to contain 50 mg diclofenac natrium was obtained from (Novartis, Cairo, Egypt). Poly (vinyl chloride) (PVC) of high molecular weight, dibutyl phthalate (DBP), ortho nitrophenyl octyl ether (o-NPOE), and graphene nano-platelets powder hydrophobic were purchased from (Sigma-Aldrich, St. Louis, USA). Phosphotungestic acid (PTA) was purchased from (Fluka, Switzerland). Sodium tetraphenylborate (Na-TPB) was from (oxford lab fine chem, India). Ammonium Reinecke (RKT) and monobasic sodium phosphate were from (Riedel–De Haen AG, Hannover, Germany). Graphite powder (particle size < 50 μm) was purchased from (Merck, Darmstadt, Germany). All the reagents were of analytical grade and the experiments were constructed using double distilled water.

Polyvinyl chloride (PVC) membrane components including PVC, dibutyl phthalate (DBP) and ortho nitrophenyl octyl ether (oNPOE) were obtained from Sigma-Aldrich, USA. Other components including tricresyl phosphate (TCP) and sodium tetraphenylborate (Na-TPB) belong to Fluka Company, Switzerland. Tetrahydrofuran and Lipohilic ion exchanger Potassium tetrakis(4-chlorophenyl)borate (KTCPB) were purchased from Alfa Aesar, Germany. Cyclohexanone was purchased from Sigma-Aldrich, USA and Acetone was from Thermo Fisher Scientific, USA. Hexachloroplatinic acid and graphite powder (particle size < 50 μm) were purchased from Merck, Germany. Tetrachloroaurate (III) hydrate was purchased from Alfa Aesar, Germany. Alogliptin Benzoate, saxagliptin HCl and vildagliptin drug substances (DS) were obtained from National Organization for Drug Control and Research (NODCAR), Giza, Egypt. All other solutions were prepared from analytical grade chemicals and double distilled water.

Ranitidine hydrochloride (RNT-HCl), magnesium nitrate hexahydrate, aluminum nitrate hexahydrate, hydrochloric acid 37%, sodium hydroxide, acetone 99.9%, tetrahydrofuran (THF) 97.0%, methanol 99.9%, ortho-nitrophenyloctyl ether (o-NPOE), phosphomolybdic acid, ethanol 99.9%, and polyvinyl chloride (PVC, high molecular weight) were provided by Sigma Aldrich (Hamburg, Germany). The medication form of RNT HCl, Ranimax^® tablets (150 mg ranitidine hydrochloride/tablet) were obtained from Jazeera Pharmaceutical Industries (Riyadh, Saudi Arabia).