Signa excite system

Manufactured by GE Healthcare

Sourced in United States

The Signa Excite system is a magnetic resonance imaging (MRI) platform developed by GE Healthcare. It is designed to provide high-quality imaging capabilities for various clinical applications. The Signa Excite system utilizes advanced hardware and software technologies to acquire detailed images of the human body.

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Lab products found in correlation

Eight channel phased array head coil, by GE Healthcare (4 mentions) 8 channel head coil, by GE Healthcare (1 mentions) Matlab version 7, by MathWorks (1 mentions) 8 channel phased array head coil, by GE Healthcare (1 mentions)

12 protocols using signa excite system

Resting-state fMRI Acquisition Protocol

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Resting-state fMRI (Rs-fMRI) data were collected by a GE 3.0T MRI scanner (Signa Excite System, General Electric Medical Systems, Milwaukee, WI, USA) with an 8-channel head coil. During the scanning, the subjects' sense of vision and hearing was blocked by wearing blindfolds (Hanjiang Xinhua Tourist Supplies Factory, Yangzhou, Jiangsu Province, China) and earplugs (Aearo, Indianapolis, IN, USA) to avoid audio-visual interference. They were also told to be relaxed and breathe peacefully with their heads fixed by foam headrests to reduce active or passive movements. The scanning procedure was performed as follows:
(1) Transverse T1-Weighted Image (T1WI) Sequence. 2 minutes, fast spin echo sequence; OAx T1 FLAIR, repetition time = 1,750 ms, echo time = 24 ms, inversion time = 960 ms, field of view = 24 × 24 cm2, matrix = 320 × 224, number of excitations = 1, thickness = 5.0 mm; interval = 1.0 mm; slice layers = 30; echo train length = 8; bandwidth = 31.25.
(2) Resting-State fMRI Blood-Oxygen-Level Dependent Data Collection. Gradient echo-echo-planar imaging sequence scanning was used for 6 minutes, with the following scan parameters: repetition time = 3,000 ms/minimum, echo time = minimum; flip angle = 90°; field of view = 240 mm × 240 mm; thickness = 5.0 mm; interval = 1.0 mm; slice layer = 30 slices per acquisition; matrix = 96 × 96; number of excitations = 1.

Zhang J., Cai X., Wang Y., Zheng Y., Qu S., Zhang Z., Yao Z., Chen G., Tang C, & Huang Y. (2019). Different Brain Activation after Acupuncture at Combined Acupoints and Single Acupoint in Hypertension Patients: An Rs-fMRI Study Based on ReHo Analysis. Evidence-based Complementary and Alternative Medicine : eCAM, 2019, 5262896.

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Functional MRI Acquisition and Processing

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A 1.5-T Signa Excite system (General Electric Milwaukee, WI, USA) magnetic resonance, equipped with an 8-channel phased-array head coil and single-shot echoplanar imaging software was used. The functional sequence consisted of gradient recalled acquisition in the steady state (repetition time (TR) = 2000 ms, echo time (TE) = 50ms and pulse angle, 90°) in a 24 cm field of view, 64 x 64 pixel matrix and a slice thickness of 4mm (inter-slice gap, 1.5 mm). A total of 22 interleaved sections, parallel to the anterior—posterior commissure line, were acquired to generate 216 whole-brain volumes, excluding four initial dummy volumes to allow the magnetization to reach equilibrium.
Data were processed on a Macintosh platform running Matlab version 7.14 (The MathWorks, Inc) and statistical parametric mapping software version 8 (SPM8). Within participants, time-series of acquired images were initially realigned to the mean image by using a least squares and a 6-parameter (rigid body) spatial transformation. Images were then normalized to the standard echoplanar imaging (EPI) template in SPM and resliced in Montreal Neurological Institute (MNI) space (resulting voxel size 2 mm³). Finally, they were smoothed with an 8 mm isotropic Gaussian filter. All image sequences were routinely inspected for potential movement or normalization artifacts.

Via E., Soriano-Mas C., Sánchez I., Forcano L., Harrison B.J., Davey C.G., Pujol J., Martínez-Zalacaín I., Menchón J.M., Fernández-Aranda F, & Cardoner N. (2015). Abnormal Social Reward Responses in Anorexia Nervosa: An fMRI Study. PLoS ONE, 10(7), e0133539.

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Functional Neuroimaging with 3T MRI

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A 3T General Electric Signa Excite system with an eight-channel phased-array head coil was used in combination with ASSET parallel imaging. The functional sequence consisted of a single shot gradient-recalled echoplanar imaging sequence in the steady state (repetition time, 2000 ms; echo time, 35 ms; and pulse angle, 90°) in a 23-cm field-of-view, with a 64 × 64-pixel matrix and a slice thickness of 3.5 mm (no gap). Thirty-six interleaved slices were acquired parallel to the anterior-posterior commissure line with a 20° anterior tilt to better cover ventral prefrontal brain regions. The total sequence duration was 10 min and 32 s, corresponding to 311 whole-brain echoplanar imaging volumes. The first four volumes from each run were automatically discarded to allow for signal equilibration. A T1-weighted high-resolution anatomic image was acquired for each participant to assist with functional time-series coregistration (140 contiguous slices; repetition time, 7.9 s; echo time, 3 s; flip angle, 13°; in a 25.6-cm field-of-view, with a 256 × 256-pixel matrix and a slice thickness of 1 mm). To assist with noise reduction and head immobility, all participants used earplugs and had their heads supported with foam-padding inserts.

Jamieson A.J., Davey C.G, & Harrison B.J. (2021). Differential Modulation of Effective Connectivity in the Brain’s Extended Face Processing System by Fearful and Sad Facial Expressions. eNeuro, 8(2), ENEURO.0380-20.2021.

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Functional MRI with Habituation Protocol

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A 1.5-Tesla Signa Excite system (General Electric, Milwaukee, WI) equipped with an eight-channel phased array head coil and single-shot echoplanar imaging (EPI) software was used. High-resolution 3D anatomical images were obtained using an axial T1-weighted three-dimensional fast spoiled gradient inversion recovery prepared sequence. A total of 134 contiguous slices were acquired with inversion time 400 ms, repetition time 11.9 ms, echo time 4.2 ms, flip angle 15°, field of view 30 cm, 256 × 256 pixel matrix, and slice thickness 1.2 mm. Each participant was assigned an MRI practice session with a specifically designed mock scanner to allow for habituation and minimize the probability of head motion during actual MRI sessions.

Pujol J., Fenoll R., Ribas-Vidal N., Martínez-Vilavella G., Blanco-Hinojo L., García-Alba J., Deus J., Novell R, & Esteba-Castillo S. (2018). A longitudinal study of brain anatomy changes preceding dementia in Down syndrome. NeuroImage : Clinical, 18, 160-166.

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Multimodal Neuroimaging of Somatic Perception

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Subjects remained conscious throughout. They were placed in a supine position and asked to breathe calmly. Their heads were fixed with a foam mat to minimize voluntary and involuntary movements. Earplugs were used to reduce hearing, and eye masks were used to avoid visual stimulation. The scan began after the volunteers had rested for 15 minutes. Experiments were conducted on a GE 3.0T MRI scanner (Signa Excite System, General Electric Medical Systems, Milwaukee, WI, USA) with an 8-channel head coil. MRI data were collected 15 minutes before needle insertion and 15 minutes after needle withdrawal, as follows:
(1) Transverse T1-weighted image (T1WI) sequence: 2 minutes, fast spin echo sequence; OAx T1 FLAIR, repetition time = 1,750 ms, echo time = 24 ms, inversion time = 960 ms, field of view = 24 × 24 cm², matrix = 320 × 224, number of excitations = 1, thickness = 5.0 mm; interval = 1.0 mm; slice layers = 30; echo train length = 8; bandwidth = 31.25.
(2) Resting-state fMRI blood-oxygen-level dependent data collection: gradient echo-echo-planar imaging sequence scanning was used for 6 minutes, with the following scan parameters: repetition time = 3,000 ms/minimum, echo time = minimum; flip angle = 90°; field of view = 240 mm × 240 mm; thickness = 5.0 mm; interval = 1.0 mm; slice layer = 30 slices per acquisition; matrix = 96 × 96; number of excitations = 1.

Zhang S.Q., Wang Y.J., Zhang J.P., Chen J.Q., Wu C.X., Li Z.P., Chen J.R., Ouyang H.L., Huang Y, & Tang C.Z. (2015). Brain activation and inhibition after acupuncture at Taichong and Taixi: resting-state functional magnetic resonance imaging. Neural Regeneration Research, 10(2), 292-297.

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Resting-State fMRI Acquisition Protocol

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In all study samples, functional MRI was acquired in the resting state and as the first sequence in the session. Participants were instructed to relax, stay awake, and lie still, while keeping their eyes closed throughout. Each scan was obtained using eight-channel phased-array head coils and single-shot echo-planar imaging (EPI) software. The functional sequences always consisted of gradient recalled acquisition in the steady state, lasted 6 min, and generated 180 whole-brain image volumes (TR, 2 s).
Functional MRI for the Osteoarthritis Sample 1 and the corresponding control group was acquired using a 1.5-T Signa Excite system (General Electric, Milwaukee, WI, USA) with acquisition parameters set as repetition time, 2000 ms; echo time, 50 ms; pulse angle, 90°; 24-cm field of view; 64 × 64-pixel matrix; and slice thickness 4 mm. Functional MRI for the rest of the samples was acquired using a Philips Achieva 3.0-T magnet (Philips Healthcare, Best, The Netherlands) with repetition time, 2000 ms; echo time, 35 ms; pulse angle, 70°; 23-cm field of view; 64 × 64-pixel matrix; and slice thickness, 3.59 mm. High-resolution 3D anatomical images were also obtained in each case based on a T1-weighted three-dimensional fast spoiled gradient inversion recovery-prepared sequence, which served to assist image processing.

Pujol J., Blanco-Hinojo L., Doreste A., Ojeda F., Martínez-Vilavella G., Pérez-Sola V., Deus J, & Monfort J. (2022). Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients. Arthritis Research & Therapy, 24, 252.

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High-resolution MRI and Diffusion Imaging

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MRI was collected on a 3 T short bore GE Signa Excite system. High-resolution
spoiled gradient recalled anatomical images were acquired in a sagittal
orientation (repetition time (TR) = 8.2 ms; echo time (TE) = 3.2 ms; field of
view (FOV) = 24 cm; flip angle = 12°; voxel size = 1 × 0.9375 × 0.9375 mm).
Diffusion-weighted images were collected using an echoplanar pulse sequence with
70 contiguous 2-mm-thick axial slices and 38 noncollinear diffusion gradients
(TR = 10 s; TE = 77.99 ms; b value = 800 s/mm²; FOV = 25.6 cm; flip
angle = 90°; voxel size = 2 × 2 × 2 mm).

Weis C.N., Belleau E.L., Pedersen W.S., Miskovich T.A, & Larson C.L. (2018). Structural Connectivity of the Posterior Cingulum Is Related to Reexperiencing Symptoms in Posttraumatic Stress Disorder. Chronic Stress, 2, 2470547018807134.

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High-Resolution Brain Imaging Protocol

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The MRI was collected on a 3.0T short bore GE Signa Excite system. High resolution T1 spoiled gradient recalled (SPGR) images were acquired in a sagittal orientation (TR = 8.2 ms; TE = 3.2 ms; FOV = 24 cm; flip angle = 12°; voxel size = 1 mm × 0.9375 mm × 0.9375 mm). Diffusion weighted images (DWI) were collected using an echoplanar pulse sequence with 70 contiguous 2 mm axial slices and 38 non-collinear diffusion gradients (TR = 10 s; TE = 77.99 ms; b-value = 800 s/mm²; FOV = 25.6 cm; flip angle = 90°; voxel size = 2 mm × 2 mm × 2 mm).

Weis C.N., Huggins A.A., Miskovich T.A., Fitzgerald J.M., Bennett K.P., Krukowski J.L., Webb E.K., deRoon-Cassini T.A, & Larson C.L. (2021). Acute White Matter Integrity Post-trauma and Prospective Posttraumatic Stress Disorder Symptoms. Frontiers in Human Neuroscience, 15, 742198.

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High-Resolution T1-Weighted Brain Imaging

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A 1.5 Tesla Signa Excite system (General Electric, Milwaukee, WI, USA) equipped with an eight-channel phased-array head coil was used. The imaging protocol for each subject involved the acquisition of high-resolution anatomical 3D images, based on a T1-weighted fast spoiled gradient inversion recovery prepared sequence. A total of 130 contiguous slices were acquired with the following parameters: inversion time 400 ms; repetition time 11.9 ms; echo time 4.2 ms; flip angle 15°; field of view 30 cm; 256 x 256 pixel matrix; slice thickness 1.2 mm.

Caixàs A., Blanco-Hinojo L., Pujol J., Deus J., Giménez-Palop O., Torrents-Rodas D., Coronas R., Novell R, & Esteba-Castillo S. (2021). Altered Gesture Imitation and Brain Anatomy in Adult Prader-Willi Syndrome Patients. Journal of the International Neuropsychological Society : JINS, 27(10).

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Functional MRI Neuroimaging Protocol

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Functional neuroimaging data were acquired using a 3-T GE Signa Excite system equipped with an eight-channel phasedarray head coil in combination with ASSET parallel imaging. The functional sequence consisted of a single-shot gradientrecalled echo planar imaging sequence in the steady state (repetition time=2 seconds, echo time=35 ms, pulse angle=90°) in a 23-cm field of view, with a 64364-pixel matrix and a slice thickness of 3.5 mm (no gap). Thirty-six interleaved slices were acquired parallel to the anteriorposterior commissure line with a 20°anterior tilt to better cover ventral prefrontal cortical brain regions. The total sequence time was 11 minutes 22 seconds, corresponding to 341 whole brain echo planar imaging volumes. A T 1 -weighted high-resolution anatomical image was acquired for each participant to assist with functional time series coregistration (140 contiguous slices, repetition time=7.9 seconds, echo time=3 seconds, flip angle=13°, in a 25.6-cm field of view, with a 2563256-pixel matrix and a slice thickness of 1 mm).

Davey C.G., Breakspear M., Pujol J, & Harrison B.J. (2017). A Brain Model of Disturbed Self-Appraisal in Depression. The American journal of psychiatry, 174(9).

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