Cobalt chloride hexahydrate

Manufactured by Thermo Fisher Scientific

Sourced in Ireland, United States

Cobalt chloride hexahydrate is an inorganic chemical compound with the formula CoCl2·6H2O. It is a crystalline solid that is typically blue in color. The compound is used in various laboratory applications as a desiccant and as an indicator for humidity and moisture detection.

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Cobalt chloride (11 citations) Cobalt (II) chloride hexahydrate (9 citations) Cobalt (II) chloride hexahydrate (CoCl2·6H2O) (2 citations)

5 protocols using cobalt chloride hexahydrate

Synthesis of PEGylated Radiolabeled Nanoparticles

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Methoxy-PEG-sulfhydryl (molecular weight, 5,000) was purchased from Nektar (San Francisco, CA). (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and 4,6-diamidino-2-phenylindole (DAPI) were purchased from Sigma-Aldrich (St. Louis, MO). Trisodium citrate dehydrate (>99%), cobalt chloride hexahydrate (99.99%), sodium borohydride (99%), and chloroauric acid trihydrate (American Chemical Society reagent grade) were purchased from Fisher Scientific (Pittsburgh, PA) and were used as received. ⁶⁴CuCl₂ radionuclide was obtained from Washington University (St. Louis, MO).

You J., Zhou J., Zhou M., Liu Y., Robertson J.D., Liang D., Van Pelt C, & Li C. (2014). Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres. Particle and Fibre Toxicology, 11, 26.

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Synthesis of Metal-Organic Frameworks

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Cobalt chloride
hexahydrate (CoCl₂·6H₂O, 98–102%)
and copper (II) sulfate pentahydrate (Cu(II)SO₄·5H₂O, 99%) were purchased from Fisher Scientific
(Ireland). All other reagents were purchased from Sigma Aldrich at
≥99% purity, apart from iron chloride hexahydrate (FeCl₃·6H₂O, 97%), zinc nitrate hexahydrate (Zn(NO₃)₂·6H₂O, 98%), sodium hydroxide
(NaOH >95%), trimesic acid (H₃BTC >95%), hexanal
(98%),
ethanol (96%), potassium phosphate dibasic (K₂HPO₄, ≥98%), hydrochloric acid (HCl, 37%), nitric acid (HNO₃, 70%), l-lactic dehydrogenase from rabbit muscle
(LDH, 800–1200 U/mg), lipase B Candida antarctica, recombinant
from Aspergillus oryzae (Lip, ∼9
U/mg), polyethylene glycol (PEG, average molecule weight 3400), PAA
(average M.W. ca. 2000), and polyethylenimine (PEI) (low molecular
weight), which were purchased from Sigma Aldrich (Ireland). All reagents
were used as received without further purification. Deionized water
(18.2 MΩ cm) was used for the preparation of all aqueous solutions.

Shortall K., Otero F., Bendl S., Soulimane T, & Magner E. (2022). Enzyme Immobilization on Metal Organic Frameworks: the Effect of Buffer on the Stability of the Support. Langmuir, 38(44), 13382-13391.

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Mesenchymal Stem Cell Culture Protocol

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All chemicals and reagents were purchased from MilliporeSigma (Burlington, MA) except the following. Cobalt chloride hexahydrate, TCEP disulfide reducing gel, calcein-AM, ethidium homodimer, and Tissue-Tek O.C.T. compound were purchased from Thermo Fisher Scientific (Waltham, MA). 10kDa four-arm PEG-maleimide (PEG-MAL) was obtained from Laysan Bio, Inc. (Arab, AL). The cysteine-terminated adhesive peptide GRGDSPC (RGD) was obtained from Genscript (Piscataway, NJ), while the MMP-degradable GCRDVPMSMRGGDRCG (VPM) peptide (received as a hydrochloric acid salt) was custom synthesized by Advanced Automated Peptide Protein Technologies (Louisville, KY). The fluorescent dye MTS-CF640R was purchased from Biotium (Fremont, CA). Cell culture reagents, including Dulbecco’s Modified Eagle Medium (DMEM), fetal bovine serum (FBS), and penicillin/streptomycin were supplied by Gibco Cell Culture (Carlsbad, CA). Primary bone marrow-derived mouse mesenchymal stem cells (mMSCs) from C57BL/6 mice were obtained from Cyagen Biosciences, Inc (Santa Clara, CA). CellTiter-Glo Luminescent Cell Viability Assay was purchased from Promega (Madison, WI). Male BALB/c mice were supplied by The Jackson Laboratory (Bar Harbor, ME).

Martin J.R., Patil P., Yu F., Gupta M.K, & Duvall C.L. (2020). Enhanced stem cell retention and antioxidative protection with injectable, ROS-degradable PEG hydrogels. Biomaterials, 263, 120377.

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Synthesis of Gold Nanoparticles

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Sodium citrate tribasic dehydrate, sodium borohydride, gold(III) chloride trihydrate, polyvinylpyrrolidone (PVP) (average molecular weight 55 000 kDa), and fetal bovine serum were purchased (Sigma-Aldrich, St. Louis, MO, USA). Cobalt chloride hexahydrate, nitric acid, hydrochloric acid, and Geltrex LDEV-Free Reduced Growth Factor Basement Membrane Matrix were purchased (Thermo Fisher Scientific, Waltham, MA, USA). CD31/PECAM-1 Recombinant Monoclonal Antibody was purchased (Bethyl Laboratories, Montgomery, TX, USA). EBM Basal Medium and EGM Endothelial Cell Growth Medium SingleQuots Supplements were purchased (Lonza, Basel, Switzerland).

Cullion K., Ostertag-Hill C.A., Pan M., Timko B., Boscolo E, & Kohane D.S. (2023). Ablation of Venous Malformations by Photothermal Therapy with Intravenous Gold Nanoshells. Nano letters, 23(15), 7092-7099.

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Synthesis and Characterization of Doxorubicin-Loaded Nanoparticles

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Sodium citrate (>99%), cobalt chloride hexahydrate (99.99%), sodium borohydride (99%), and chloroauric acid trihydrate (American Chemical Society reagent grade) were purchased from Thermo Fisher Scientific (Waltham, MA) and were used as received. Octadecyl-3-Mercaptopionate (OMP) was from Chemical Indoustry Co.(Japan). Doxorubicin.HCl (DOX) was gifted from Zhejiang Hisun Pharmaceutical Co, Ltd, (Taizhou Zhejiang, China). 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), Egg phosphatidylcholine (EPC), Dipalmitoylphosphatidylcholine (DPPC), Hydrogenated soybean phosphatidylcholine (HSPC), cholesterol (Chol), and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000] (DSPE-PEG₂₀₀₀) were purchased from Lipoid (Germany). 1,1’-dioctadecyl-3,3,3,3’-tetramethylindodicarbocyanine, 4-chlorobenzenesulfonate salt (DiD), 1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindotricarbocyanine Iodide (DiR) were obtained from Invitrogen (Carlsbad, CA, USA). 3-(4,5-dimethylthiazol-2-yl)-2,5 -diphenyltetrazolium bromide (MTT) were purchased from Sigma (St Louis, MO). All other solvents were of analytical or chromatographic grade.

You J., Zhang P., Hu F., Du Y., Yuan H., Zhu J., Wang Z., Zhou J, & Li C. (2014). Near-infrared light sensitive liposomes for the enhanced photothermal tumor treatment by the combination with chemotherapy. Pharmaceutical research, 31(3), 554-565.

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